Gut microbiota characterisation in obese patients before and after bariatric surgery

Campisciano, Giuseppina; Palmisano, Silvia; Cason, Carolina; Giuricin, Michela; Silvestri, Marta; Guerra, Martina; Macor, Daniele; Manzini, Nicoló de; Crocè, Lory Saveria; Comar, Manola

doi:10.3920/bm2017.0152

Cited by 46 publications

(36 citation statements)

References 23 publications

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“…Thirty articles were categorized into group 1 (BS and microbiota in humans). The work by Campisciano et al [ 37 , 38 ] is included as two original articles, but discussed and summarized as one due to presenting identical results. Twenty-five articles were categorized into group 2 (BS and microbiota in other vertebrates) and four articles were categorized into group 3 (BS and probiotics).…”

Section: Resultsmentioning

confidence: 99%

“…Out of the 59 studies, 36 studies applied a pre-post design (baseline measurements provided) (Group 1: n = 23 [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]; Group 2: n = 10 [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]; Group 3: n = 4 [ 70 , 71 , 72 , 73 ]). Sixteen studies used a cross-sectional design (Group 1: n = 6 [ 74 , 75 , 76 , 77 , 78 , 79 ]; Group 2: n = 10 [ 80 , 81 , 82 , 83 , 84 , 85 , 86 ,…”

Section: Resultsmentioning

confidence: 99%

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Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

et al. 2020

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The gastrointestinal (GI) microbiota plays an important role in health and disease, including brain function and behavior. Bariatric surgery (BS) has been reported to result in various changes in the GI microbiota, therefore demanding the investigation of the impact of GI microbiota on treatment success. The goal of this systematic review was to assess the effects of BS on the microbiota composition in humans and other vertebrates, whether probiotics influence postoperative health, and whether microbiota and psychological and behavioral factors interact. A search was conducted using PubMed and Web of Science to find relevant studies with respect to the GI microbiota and probiotics after BS, and later screened for psychological and behavioral parameters. Studies were classified into groups and subgroups to provide a clear overview of the outcomes. Microbiota changes were further assessed for whether they were specific to BS in humans through the comparison to sham operated controls in other vertebrate studies. Changes in alpha diversity appear not to be specific, whereas dissimilarity in overall microbial community structure, and increases in the abundance of the phylum Proteobacteria and Akkermansia spp. within the phylum Verrucomicrobia after surgery were observed in both human and other vertebrates studies and may be specific to BS in humans. Human probiotic studies differed regarding probiotic strains and dosages, however it appeared that probiotic interventions were not superior to a placebo for quality of life scores or weight loss after BS. The relationship between GI microbiota and psychological diseases in this context is unclear due to insufficient available data.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

et al. 2020

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“…Subgroup analysis showed that it may be useful in the short term in patients having undergone RYGB or OAGB, but no long-term benefits have been found in RCTs till date. Compared with SG, the composition of gut microbiota was dramatically altered in patients having undergone gastric bypass [34]. We speculate that microecological preparations improved the gut microbiota ecosystem and increased weight loss.…”

Section: Discussionmentioning

confidence: 86%

Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta‐Analysis

Zhu

Ren

Zang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Vitamin deficiency, bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight. It is unclear if microecological preparations benefit obese patients following bariatric surgery. The aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers. We searched seven databases to identify reports published till December 1, 2019, and included randomized controlled trials investigating the effects of microecological preparations in obese adults undergoing bariatric surgery. The primary outcomes included QoL and EWL, while secondary outcomes comprised serum levels of vitamin B12, interleukin 6, TNF-α, and C-reactive protein (CRP). Study bias was analyzed using the Cochrane risk-of-bias tool. Statistical analyses were performed using Review Manager. The mean difference in outcomes was calculated using standardized mean difference (SMD) with a confidence interval (CI) of 95%. A majority of the studies showed a low or moderate risk of bias. Meta-analysis showed significantly higher levels of vitamin B12 in postoperative patients administered with microecological preparations (SMD = 0.52; 95% CI = 0.08–0.95; P=0.02). There were no significant differences in QoL (SMD = −0.14; 95% CI = −0.45–0.17; P=0.38), EWL (SMD = 0.45; 95% CI = −0.16–1.05; P=0.15), and levels of TNF-α (SMD = −0.29; 95% CI = −0.64–0.05; P=0.09), interleukin 6 (SMD = −0.1; 95% CI = −0.81–0.61; P=0.78]), and CRP (SMD = 0.02; 95% CI = −0.32–0.36; P=0.93). The trials examined indicated that microecological preparations had limited efficacy in improving QoL, EWL, and inflammatory response, but they stimulated the synthesis of vitamin B12. This may help in designing efficient microecological preparations to supplement bariatric surgery in obese individuals.

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“…[10] Following bariatric surgery, increased gut microbial diversity and gene richness have been reported. [20][21][22][23][24][25] While the connection between the gut microbiome and sarcoidosis is developing, their relationship may have contributed to the resolution of sarcoidosis following bariatric surgery reported here.…”

Section: Discussionmentioning

confidence: 99%

Improvement of pulmonary sarcoidosis following sleeve gastrectomy

Hassell¹,

Grzeszczak²,

Adams³

et al. 2019

CRIM

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Pulmonary sarcoidosis is unlikely to resolve if it persists for greater than five years. A growing body of literature supports the involvement of the microbiome in sarcoidosis and a role for sex hormones in pulmonary fibrosis. Additionally, obesity is a risk factor for the development of sarcoidosis. Bariatric surgery is an effective treatment for obesity and can lead to microbial and endocrine changes. Here, we report the clinical improvement of longstanding pulmonary sarcoidosis following sleeve gastrectomy.

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Gut microbiota characterisation in obese patients before and after bariatric surgery

Cited by 46 publications

References 23 publications

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta‐Analysis

Improvement of pulmonary sarcoidosis following sleeve gastrectomy

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