Gut microbiota associated with pulmonary tuberculosis and dysbiosis caused by anti-tuberculosis drugs

Hu, Yongfeng; Yang, Qianting; Liu, Bo; Dong, Jie; Sun, Lu; Zhu, Yafang; Su, Haoxiang; Yang, Jian; Yang, Fan; Chen, Xinchun; Jin, Qi

doi:10.1016/j.jinf.2018.08.006

Cited by 90 publications

(109 citation statements)

References 18 publications

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“…The findings above, nevertheless, differed from three studies conducted in China (Table 1). 6,14,30 In particular, the studies in China observed changes in species diversity and abundance between healthy and TB patients. Unfortunately, the antimicrobials used by the cohorts in China, except for one study that used HRZE, 30 were not delineated, as was the case in Haiti (Table 1).…”

Section: Antimicrobials: the Major Enemy Of The Microbiomementioning

confidence: 99%

“…(Table 1). 6,14 Nevertheless, HRZE exposure reduced genera belonging to Clostridiales, such as Ruminococcus spp., Ruminococcus gnavus, and Faecalibacterium spp., while Bacteroidetes members, such as Bacteroides spp. (B. fragilis, B. plebeius, B. caccae, and B. coprophilus), and Parabacteroides distasonis, were significantly enriched.…”

Section: Antimicrobials: the Major Enemy Of The Microbiomementioning

confidence: 99%

“…(B. fragilis, B. plebeius, B. caccae, and B. coprophilus), and Parabacteroides distasonis, were significantly enriched. 6 These conflicting interstudy and interindividual microbiome differences before and after antimicrobial administration hamper the effective description of the general effect of TB antimicrobials on the microbiota. Specifically, they cause no changes in species diversity in some studies, while the opposite has been reported in others.…”

Section: Antimicrobials: the Major Enemy Of The Microbiomementioning

confidence: 99%

“…[1][2][3] Specifically, WGS provides deeper insights into the interconnectivity, composition, relative abundance, diversity, metabolites, and biological activities of the microbiome in different luminal surfaces of the human body. 1,[4][5][6] In particular, the lung microbiome was believed to be sterile until recently, when nonculture-based techniques showed the presence of a microbiota in the lung. 7 Furthermore, increasing evidence suggests that the intestinal micro-biota directly and/or indirectly modulates the lung microbiota by developing, regulating, and inducing the immune system.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, as Mtb can revert to dormancy/latency within the host and later revived into active disease, some investigators question whether there are different effects of latent and recurrent TB on lung-gut microbiome dynamics. 4,6,14 Given the intracellular nature of Mtb, it remains to be seen if it can directly cause dysbiosis. It is also not clear if Mtb can indirectly cause dysbiosis through immune dysregulation, particularly given that a strong association between the microbiota and immune system has been already established.…”

Section: Introductionmentioning

confidence: 99%

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Mycobacterium tuberculosis, antimicrobials, immunity, and lung–gut microbiota crosstalk: current updates and emerging advances

Sekyere

Maningi

Fourie

2020

Annals of the New York Academy of Sciences

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Increasingly, gut microbiota distortions are being implicated in the pathogenesis of several infectious and noninfectious diseases. Specifically, in the absence of an eubiotic microbiota, mice are more prone to colonization and infection by Mycobacterium tuberculosis (Mtb). In this qualitative analysis, the following were observed: (1) antimicrobials cause long-term gut microbiota perturbations; (2) Mtb causes limited and transient disturbances to the lung-gut microbiota; (3) pathogens (e.g., Helicobacter hepaticus) affect microbiota integrity and reduce resistance to Mtb; (4) dysbiosis depletes bacterial species regulating proper immune functioning, reducing resistance to Mtb; (5) dysregulated immune cells fail to express important pathogen-recognition receptors (e.g., macrophageinducible C-type lectin; MINCLE) and Mtb-killing cytokines (e.g., IFN-γ, TNF-α, and IL-17), with hampered phagocytic capability; (6) autophagy is central to the immune system's clearance of Mtb, control of inflammation, and immunity-microbiome balance; (7) microbiota-produced short-chain fatty acids, which are reduced by dysbiosis, affect immune cells and increase Mtb proliferation; (8) commensal species (e.g., Lactobacillus plantarum) and microbiota metabolites (e.g., indole propionic acid) reduce tuberculosis progression; and (9) fecal transplants mostly restored eubiosis, increased immune resistance to Mtb, restricted dissemination of Mtb, and reduced tuberculosis-associated organ pathologies. Overuse of antimicrobials, as shown in mice, is a risk factor for reactivating latent or treated tuberculosis.

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Section: Antimicrobials: the Major Enemy Of The Microbiomementioning

confidence: 99%

Section: Antimicrobials: the Major Enemy Of The Microbiomementioning

confidence: 99%

Section: Antimicrobials: the Major Enemy Of The Microbiomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mycobacterium tuberculosis, antimicrobials, immunity, and lung–gut microbiota crosstalk: current updates and emerging advances

Sekyere

Maningi

Fourie

2020

Annals of the New York Academy of Sciences

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Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

Yang,

Zhang,

Wang

et al. 2024

iMeta

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The gut microbiota is a complex community of microorganisms inhabiting the intestinal tract, which plays a vital role in human health. It is intricately involved in the metabolism, and it also affects diverse physiological processes. The gut–lung axis is a bidirectional pathway between the gastrointestinal tract and the lungs. Recent research has shown that the gut microbiome plays a crucial role in immune response regulation in the lungs and the development of lung diseases. In this review, we present the interrelated factors concerning gut microbiota and the associated metabolites in pulmonary hypertension (PH), a lethal disease characterized by elevated pulmonary vascular pressure and resistance. Our research team explored the role of gut‐microbiota‐derived metabolites in cardiovascular diseases and established the correlation between metabolites such as putrescine, succinate, trimethylamine N‐oxide (TMAO), and N, N, N‐trimethyl‐5‐aminovaleric acid with the diseases. Furthermore, we found that specific metabolites, such as TMAO and betaine, have significant clinical value in PH, suggesting their potential as biomarkers in disease management. In detailing the interplay between the gut microbiota, their metabolites, and PH, we underscored the potential therapeutic approaches modulating this microbiota. Ultimately, we endeavor to alleviate the substantial socioeconomic burden associated with this disease. This review presents a unique exploratory analysis of the link between gut microbiota and PH, intending to propel further investigations in the gut–lung axis.

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The role of gut microbiota in infectious diseases

Cai

Chen

Zhang

et al. 2022

WIREs Mechanisms of Disease

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The intestine, the largest immune organ in the human body, harbors approximately 1013 microorganisms, including bacteria, fungi, viruses, and other unknown microbes. The intestine is a most important crosstalk anatomic structure between the first (the host) and second (the microorganisms) genomes. The imbalance of the intestinal microecology, especially dysbiosis of the composition, structure, and function of gut microbiota, is linked to human diseases. In this review, we investigated the roles and underlying mechanisms of gut microecology in the development, progression, and prognosis of infectious diseases. Furthermore, we discussed potential new strategies of prevention and treatment for infectious diseases based on manipulating the composition, structure, and function of intestinal microorganisms in the future. This article is categorized under: Infectious Diseases > Molecular and Cellular Physiology

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Gut microbiota associated with pulmonary tuberculosis and dysbiosis caused by anti-tuberculosis drugs

Cited by 90 publications

References 18 publications

Mycobacterium tuberculosis, antimicrobials, immunity, and lung–gut microbiota crosstalk: current updates and emerging advances

Mycobacterium tuberculosis, antimicrobials, immunity, and lung–gut microbiota crosstalk: current updates and emerging advances

Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

The role of gut microbiota in infectious diseases

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