Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis
Abhinav Lamba,
Veena Taneja
Abstract:SummaryRheumatoid arthritis (RA) is considered a multifactorial condition where interaction between the genetic and environmental factors lead to immune dysregulation causing autoreactivity. While among the various genetic factors, HLA‐DR4 and DQ8, have been reported to be the strongest risk factors, the role of various environmental factors has been unclear. Though events initiating autoreactivity remain unknown, a mucosal origin of RA has gained attention based on the recent observations with the gut dysbios… Show more
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