Gut microbiota as a driver of the interindividual variability of cardiometabolic effects from tea polyphenols

Li, Qiqiong; Wiele, Tom Van de

doi:10.1080/10408398.2021.1965536

Cited by 16 publications

(18 citation statements)

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“…It is known that the C-ring cleavage is a critical metabolic step for the human microbial metabolism of several flavonoids [ 26 ]. In the case of catechins, this step facilitates the formation of diphenylpropanol (M1) and can be performed by several bacteria such as Eggerthella lenta and Adlercreutzia equolifaciens [ 8 ]. The resulting M1 then underwent the degradation of the phloroglucinol moiety to produce M2 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone and M3 4-hydroxy-(3′,4′-dihydroxyphenyl)-valeric acid, which may be subsequently converted to corresponding valerolactone M6 and valeric acid by dephydroxylation at the 4′ position.…”

Section: Resultsmentioning

confidence: 99%

“…It is noteworthy that M4 and M5 are not the end products of microbial metabolism of (+)-catechin, and they can be further converted by β-or α-oxidation [ 25 ]. The entire metabolic pathway of catechin may require the cooperation of different bacteria, but currently, only a few bacteria have been identified to be able to metabolize (+)-catechin [ 8 ]. To conclude, the formation of upstream metabolites involves the metabolism steps of C-ring opening, A-ring fission while the formation of downstream metabolites involves degradation reactions, including the dehydroxylation of the phenyl moiety and the shortening of the aliphatic chain of phenylvaleric acids.…”

Section: Resultsmentioning

confidence: 99%

“…A small fraction of the ingested catechins is absorbed and undergoes phase I and phase II metabolism within small intestinal enterocytes and liver by enzymes, such as glucuronosyltransferases, sulfotransferases and catechol-O-methyltransferase [ 6 ]. Approximately two-thirds of catechins reach the colon where catechins are degraded by microbial enzymes into a range of metabolites [ 7 , 8 ]. The human gastrointestinal tract is colonized by an extremely dense and diverse microbial community [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The enormous gene pool of the gut microbiota makes the colon a bioreactor with great potential for polyphenol metabolism [ 10 ]. The gut microbiota has the metabolic capacity to perform glycosidic linkages, C-ring fission and the degradation of the heterocyclic structures of catechins, forming smaller molecules, including phenylvalerolactones and phenylvaleric acids [ 8 ]. These generated microbial metabolites of a wide variety of new chemical structures are available for absorption across the colon epithelium and can eventually enter the systemic blood circulation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem

Herreweghen

Mey

et al. 2021

Molecules

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The intestinal absorption of dietary catechins is quite low, resulting in most of them being metabolized by gut microbiota in the colon. It has been hypothesized that microbiota-derived metabolites may be partly responsible for the association between catechin consumption and beneficial cardiometabolic effects. Given the profound differences in gut microbiota composition and microbial load between individuals and across different colon regions, this study examined how microbial (+)-catechin metabolite profiles differ between colon regions and individuals. Batch exploration of the interindividual variability in (+)-catechin microbial metabolism resulted in a stratification based on metabolic efficiency: from the 12 tested donor microbiota, we identified a fast- and a slow-converting microbiota that was subsequently inoculated to SHIME, a dynamic model of the human gut. Monitoring of microbial (+)-catechin metabolites from proximal and distal colon compartments with UHPLC-MS and UPLC-IMS-Q-TOF-MS revealed profound donor-dependent and colon-region-dependent metabolite profiles with 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone being the largest contributor to differences between the fast- and slow-converting microbiota and the distal colon being a more important region for (+)-catechin metabolism than the proximal colon. Our findings may contribute to further understanding the role of the gut microbiota as a determinant of interindividual variation in pharmacokinetics upon (+)-catechin ingestion.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem

Herreweghen

Mey

et al. 2021

Molecules

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“…In a retrospective study of 1,591 severely ill patients with COVID-19, hypertension was the most common comorbidity (49%), followed by cardiovascular disease (21%), hypercholesterolemia (18%), and diabetes (17%) ( 68 ). Patients with COVID-19 can develop complications of lung disease (cough, decreased lung diffusivity, sleep apnea, and pulmonary fibrosis), cardiovascular disease (diabetes, arrhythmia, and myocarditis), and neurological disorder (depression, anxiety, and attention disorders) ( 69 ). TP can effectively prevent and treat some complications.…”

Section: Reduction Of Covid-19 Comorbidity Risk By Tpsmentioning

confidence: 99%

Potential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung Axis

Liu

et al. 2022

Front. Nutr.

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Coronavirus disease 2019 (COVID-19) disrupts the intestinal micro-ecological balance, and patients often develop the intestinal disease. The gut is the largest immune organ in the human body; intestinal microbes can affect the immune function of the lungs through the gut-lung axis. It has been reported that tea polyphenols (TPs) have antiviral and prebiotic activity. In this review, we discussed TPs reduced lung-related diseases through gut-lung axis by inhibiting dysbiosis. In addition, we also highlighted the preventive and therapeutic effects of TPs on COVID-19 complications, further demonstrating the importance of research on TPs for the prevention and treatment of COVID-19 in humans. Based on this understanding, we recommend using TPs to regulate the gut microbiota to prevent or alleviate COVID-19 through the gut-lung axis.

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Assessing the Gut Microbiota's Ability to Metabolize Oligomeric and Polymeric Flavan‐3‐ols from Aronia and Cranberry

Lessard‐Lord,

Roussel,

Guay

et al. 2024

Molecular Nutrition Food Res

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Clinical trials investigating the health effects of flavan‐3‐ols yield heterogeneous results due to interindividual variability in the gut microbiota metabolism. In fact, different groups in the population have similar metabolic profiles following (−)‐epicatechin and (+)‐catechin gut microbial metabolism and can be regrouped into so‐called metabotypes. In this study, the capacity of 34 donors to metabolize polymeric B‐type flavan‐3‐ols from aronia and oligomeric A‐type flavan‐3‐ols from cranberry is investigated by in vitro fecal batch fermentations. Less than 1% of the flavan‐3‐ols from both sources are converted into microbial metabolites, such as phenyl‐γ‐valerolactones (PVLs). To further confirm this result, gut microbial metabolites from flavan‐3‐ols are quantified in urine samples collected from participants, before and after a 4‐day supplementation of cranberry extract providing 82.3 mg of flavan‐3‐ols per day. No significant difference is observed in the urinary excretion of flavan‐3‐ols microbial metabolites. Hence, it demonstrates by both in vitro and in vivo approaches that flavan‐3‐ols from aronia and cranberry are poorly degraded by the gut microbiota. The beneficial health impacts of these molecules likely stem from their capacity to affect gut microbiota and their interactions with the gut epithelium, rather than from their breakdown into smaller metabolites.

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Gut microbiota as a driver of the interindividual variability of cardiometabolic effects from tea polyphenols

Cited by 16 publications

References 185 publications

The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem

The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem

Potential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung Axis

Assessing the Gut Microbiota's Ability to Metabolize Oligomeric and Polymeric Flavan‐3‐ols from Aronia and Cranberry

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