Gut microbiota and systemic inflammation in patients with chronic heart failure

Abstract

Aim To study the interrelationship between intensity of chronic systemic inflammation (CSI) with severity of the condition and intestinal microbiocenosis parameters in patients with chronic heart failure (CHF).Material and methods 47 hospitalized patients with symptomatic CHF were evaluated. The following parameters were determined: clinical condition; N-terminal pro-B-type natriuretic peptide (NT-proBNP). C-reactive protein (CRP); serum interleukins (IL) 6 and 10; and intestinal microbiocenosis composition by mass-spectrometry of microbial markers in whole blood. Microbiocenosis indexes were compared in the main group and in 38 outpatient patients with arterial hypertension and ischemic heart disease without CHF.Results Direct, medium-power correlations were found between CRP and IL-6 concentrations and severity of clinical condition (NT-proBNP, ХСН stage, and edema severity) in patients with CHF. Most patients with CHF had lower numbers of bifido-, lacto-, propionic-, and eubacteria, and Clostridium (С.) ramosum and higher numbers of aspergillus. Among CHF patients, the highest indexes of endotoxemia, gram (-) bacteria, cocci, actinomycetes, and microfungi were observed in the group with NT-proBNP from 400 to 2000 pg/ml. Direct correlations were observed for amounts of C. hystolyticum, Pseudonocardia spp., and Aspergillus spp. with IL-6 and IL-10 and unidirectional inverse correlation were observed for these cytokines with Propionibacterium acnes and jensenii, Streptomyces spp., and Nocardia asteroides. In addition, IL-6 concentration was negatively correlated with contents of Staphylococcus aureus, C. difficile, C. ramosum, Eggerthella lenta, and Corynebacterium spp. and was positively correlated with C. propionicum, Moraxella spp. and Flavobacterium spp. Concentration of IL-6 directly correlated with the number of Eubacterium spp. and inversely correlated with numbers of Ruminicoccus spp. and Streptomyces farmamarensis. The amount of Streptomyces farmamarensis negatively correlated with CRP concentrations.Conclusion The study results evidence the significance of intestinal microbial-tissue complex in the pathogenesis of CSI in CHF and allow suggesting this complex as a promising target for therapy.

The Role of Gut Microbiota and Its Metabolites in Patients with Heart Failure

“…A study by Vlasov et al may confirm this. They observed that patients with chronic HF had lower levels of Ruminococcus-specific fatty acids than the control group [41].…”

The impact of probiotic yogurt versus ordinary yogurt on serum sTWEAK, sCD163, ADMA, LCAT and BUN in patients with chronic heart failure: a randomized, triple‐blind, controlled trial

“…In addition, CD40L, monocyte chemoattractant protein‐1 (MCP‐1), adhesion molecules, myeloperoxidase and various interleukins have been studied for this purpose in addition to CRP in recent years, but no significant predictive value has been determined 4 . However, recent studies indicate the potential role of inflammation and oxidative stress and the causative agents in this disease 5 . Recent studies have shown that serum levels of soluble tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK) and its receptor, cluster of differentiation 163 (CD163), may act as a cardiovascular biomarker along with other biomarkers involved in the progression of inflammation that have not been potentially studied 6 and sTWEAK have been shown to be reduced in inflammatory diseases such as HF which is associated with higher clinical complications in patients 7,8 …”

“…4 However, recent studies indicate the potential role of inflammation and oxidative stress and the causative agents in this disease. 5 Recent studies have shown that serum levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and its receptor, cluster of differentiation 163 (CD163), may act as a cardiovascular biomarker along with other biomarkers involved in the progression of inflammation that have not been potentially studied 6 and sTWEAK have been shown to be reduced in inflammatory diseases such as HF which is associated with higher clinical complications in patients. 7,8 TWEAK is a member of the TNF superfamily and controls many cellular functions through its receptor fibroblast growth factorinducible 14 (Fn14).…”

Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

“…Infl ammation is a common pathological process underlying diseases of infectious and non-infectious etiology, and is also one of the main regulatory mechanisms maintaining homeostasis; however, disturbance of regulation in some cases causes infl ammation to become chronic, acquiring a damaging character. The mechanisms of infl ammation are realized through the development of a systemic infl ammatory reaction, the main initiating mechanism of which is deliv-ery of cytokines and various other infl ammatory mediators into the bloodstream, leading to activation of the complement and hemostasis systems, leukocytes, microcirculatory disorders, and the development of destructive changes at lesion sites [1,2].…”