Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration

Joseph, Narcisse; Vasodavan, Kalidasan; Saipudin, Nurul Ain; Yusof, Barakatun Nisak Mohd; Kumar, Suresh; Nordin, Syafinaz Amin

doi:10.1016/j.jff.2019.03.042

Cited by 39 publications

(37 citation statements)

References 44 publications

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“…Both in normal weight and overweight children after four weeks of supplementation, a significant increase in SCFAs concentration, especially of propionic acid, was observed. In addition, a higher SCFAs concentration (especially butyric and propionic acid) was observed in the stool of overweight children than in normal weight children ( Table 5) [2]. Also, when Lactobacillus casei Shirota was administered to children with obesity for six months, there was an improvement in the profile of intestinal microbiota and an increase in the concentration of acetic acid in the faces of children with obesity (Table 5) [24].…”

Section: Obesitymentioning

confidence: 99%

“…The VSL#3-induced changes were associated with an increase in the levels of a short-chain fatty acid (SCFAs), butyrate [117]. In another study feces from 40 Malaysian school-age children (19 of normal weight and 21 overweight children) who consumed a probiotic drink containing the Lactobacillus casei Shirota strain in two stages (four weeks each) were examined [2]. It was found that the consumption of the probiotic drink caused a significant increase in the number of Lactobacillus spp.…”

Section: Obesitymentioning

confidence: 99%

“…Two bacterial phyla, Gram-positive Firmicutes (Lactobacillus spp., Bacillus spp., and Clostridium spp.) and Gram-negative Bacteroidetes, predominate in human gut [2].…”

Section: Introductionmentioning

confidence: 99%

“…It should also be noted that Faecalibacterium prausnitzii is the first anti-inflammatory commensal bacterium identified on the basis of human clinical data and is also one of the major butyrate-producer of the human intestinal microbiome [20,21]. Other studies have shown a higher concentration of SCFAs (especially butyric and propionic acid) in the feces of overweight children compared to healthy children [2]. Similar results were obtained in a study of Swiss children, in this case the concentration of butyric and propionic acid was also significantly higher in the feces of overweight children [22].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the trend of SCFAs content in feces cannot be dependent on a specific BMI group. Instead, the concentration of these acids is more associated with dysbiosis of the intestinal microbiome, genetics, environmental factors and diet [2].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

2020

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The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids—SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host’s normal health and prevent many diseases. The results of many studies confirm the beneficial effect of probiotic microorganisms on the balance of the intestinal microbiome and produced metabolites, including SCFAs. The aim of this review is to summarize what is known on the effects of probiotics on the production of short-chain fatty acids by gut microbes. In addition, the mechanism of formation and properties of these metabolites is discussed and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome is presented.

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Section: Obesitymentioning

confidence: 99%

Section: Obesitymentioning

confidence: 99%

“…Two bacterial phyla, Gram-positive Firmicutes (Lactobacillus spp., Bacillus spp., and Clostridium spp.) and Gram-negative Bacteroidetes, predominate in human gut [2].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

2020

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Fructooligosaccharides as Prebiotics, their Metabolism, and Health Benefits

Rosa¹,

Flores-Gallegos²,

Ascacio‐Valdés³

et al. 2022

Probiotics, Prebiotics and Synbiotics

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Probiotic supplementation attenuates age‐related sarcopenia via the gut–muscle axis in SAMP8 mice

Chen

Chang

et al. 2021

J cachexia sarcopenia muscle

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Background Age-related muscle dysfunctions are common disorders resulting in poor quality of life in the elderly. Probiotic supplementation is a potential strategy for preventing age-related sarcopenia as evidence suggests that probiotics can enhance muscle function via the gut-muscle axis. However, the effects and mechanisms of probiotics in age-related sarcopenia are currently unknown. In this study, we examined the effects of Lactobacillus casei Shirota (LcS), a probiotic previously reported to improve muscle function in young adult mice. Methods We administered LcS (1 × 10 8 or 1 × 10 9 CFU/mouse/day) by oral gavage to senescence-accelerated mouse prone-8 mice for 12 weeks (16-to 28-week-old). Sixteen-week-old and 28-week-old SMAP8 mice were included as non-aged and aged controls, respectively. Muscle condition was evaluated using dual-energy X-ray absorptiometry for muscle mass, holding impulse and grip strength tests for muscle strength, and oxygen consumption rate, gene expressions of mitochondrial biogenesis, and mitochondrial number assays for mitochondria function. Inflammatory cytokines were determined using enzyme-linked immunosorbent assay. Gas chromatography-mass spectrometry was utilized to measure the short-chain fatty acid levels. The gut microbiota was analysed based on the data of 16S rRNA gene sequencing of mouse stool. ResultsThe LcS supplementation reduced age-related declines in muscle mass (>94.6%, P < 0.04), strength (>66% in holding impulse and >96.3% in grip strength, P < 0.05), and mitochondrial function (P < 0.05). The concentration of short-chain fatty acids (acetic, isobutyric, butyric, penic, and hexanoic acid) was recovered by LcS (>65.9% in the mice given high dose of LcS, P < 0.05) in the aged mice, and LcS attenuated age-related increases in inflammation (P < 0.05) and reactive oxygen species (>89.4%, P < 0.001). The high dose of LcS supplementation was also associated with distinct microbiota composition as indicated by the separation of groups in the beta-diversity analysis (P = 0.027). LcS supplementation altered predicted bacterial functions based on the gut microbiota. Apoptosis (P = 0.026), p53 signalling (P = 0.017), and non-homologous end-joining (P = 0.031) were significantly reduced, whereas DNA repair and recombination proteins (P = 0.043), RNA polymerase (P = 0.008), and aminoacyl-tRNA biosynthesis (P = 0.003) were increased. Finally, the genera enriched by high-dose LcS [linear discriminant analysis (LDA) score > 2.0] were positively correlated with healthy muscle and physiological condition (P < 0.05), while the genera enriched in aged control mice (LDA score > 2.0) were negatively associated with healthy muscle and physiological condition (P < 0.05). Conclusions Lactobacillus casei Shirota represents an active modulator that regulates the onset and progression of age-related muscle impairment potentially via the gut-muscle axis.

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Gut microbiota and short-chain fatty acids (SCFAs) profiles of normal and overweight school children in Selangor after probiotics administration

Cited by 39 publications

References 44 publications

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

Fructooligosaccharides as Prebiotics, their Metabolism, and Health Benefits

Probiotic supplementation attenuates age‐related sarcopenia via the gut–muscle axis in SAMP8 mice

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