Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice

Wang, Guanhao; Liu, Qing; Guo, Liang; Zeng, Haijuan; Ding, Changming; Zhang, Wentong; Xu, Dongpo; Wang, Xiang; Qiu, Jingxuan; Dong, Qingli; Fan, Zhipeng; Zhang, Qi; Pan, Jing

doi:10.3389/fmicb.2018.01874

Cited by 45 publications

(45 citation statements)

References 86 publications

(91 reference statements)

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“…3,22 A recent publication assessed ethanol-induced changes of the fecal microbiome and metabolome in mice. 24 In line with our findings, alpha diversity measures were similar and community clustering differed in control-versus ethanol-fed mouse feces. In a study with rats, ethanol reduced abundance of Lactobacillus and increased Bacteroides and Parabacteroides, which was also observed in our study.…”

Section: Discussionsupporting

confidence: 89%

Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice

et al. 2019

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Alcohol-induced liver disease is closely related to translocation of bacterial products and bacteria from the intestine to the liver. However, it is not known whether bacterial translocation to the liver depends on certain intestinal microbiota changes that would predispose bacteria to translocate to the liver. In this study, we investigated the microbiota in the jejunum, ileum, cecum, feces and liver of mice subjected to chronic ethanol feeding using a Lieber DeCarli diet model of chronic ethanol feeding for 8 weeks. We demonstrate that chronic ethanol administration changes alpha diversity in the ileum and the liver and leads to compositional changes especially in the ileum. This is largely driven by an increase in gram-negative phylathe source of endotoxins. Moreover, gram-negative Prevotella not only increased in the mucus layer of the ileum but also in liver samples. These results suggest that bacterial translocation to the liver might be associated with microbiota changes in the distal gastrointestinal tract.

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Section: Discussionsupporting

confidence: 89%

Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice

et al. 2019

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“…For instance, butyric acid mainly derived from Firmicutes , may influence the immune milieu of brain through changing peripheral immune system function and attenuating neuroinflammation. In addition, it regulates serotonin and gut hormone levels in the enteric nervous system [73]. Serotonin is a neurotransmitter that can modulate intestinal motility through its 5-HT receptors on different cell types of the GIT, mainly enterocytes, enteric neurons, and immune cells and, given its role in humor regulation, the effect of microbiota composition on social behavior could be explained.…”

Section: Gut Microbiota: the Mirror Of Your Addictionmentioning

confidence: 99%

Alcohol or Gut Microbiota: Who Is the Guilty?

Meroni

Longo

Dongiovanni

2019

IJMS

118

112

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Alcoholic liver disease (ALD), a disorder caused by excessive alcohol intake represents a global health care burden. ALD encompasses a broad spectrum of hepatic injuries including asymptomatic steatosis, alcoholic steatohepatitis (ASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The susceptibility of alcoholic patients to develop ALD is highly variable and its progression to more advanced stages is strongly influenced by several hits (i.e., amount and duration of alcohol abuse). Among them, the intestinal microbiota and its metabolites have been recently identified as paramount in ALD pathophysiology. Ethanol abuse triggers qualitative and quantitative modifications in intestinal flora taxonomic composition, mucosal inflammation, and intestinal barrier derangement. Intestinal hypermeability results in the translocation of viable pathogenic bacteria, Gram-negative microbial products, and pro-inflammatory luminal metabolites into the bloodstream, further corroborating the alcohol-induced liver damage. Thus, the premise of this review is to discuss the beneficial effect of gut microbiota modulation as a novel therapeutic approach in ALD management.

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“…Differences in these studies may be attributable differences in sample type and location (stool versus colon contents) (Bull-Otterson et al 2013;Fan et al 2018). Furthermore, work by Wang et al (2018b) suggests that alcohol use not only affects the composition of the gut microbiome, but also its production of bioactive metabolites such as serotonin and bile acids.…”

Section: The Gut Microbiome In Addictionmentioning

confidence: 99%

A potential role for the gut microbiome in substance use disorders

2019

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Pathological substance use disorders represent a major public health crisis with limited effective treatment options. While much work has been done to understand the neuronal signaling networks and intracellular signaling cascades associated with prolonged drug use, these studies have yielded few successful treatment options for substance use disorders. In recent years, there has been a growing interest to explore interactions between the peripheral immune system, the gut microbiome and the CNS. In this review we will present a summary of existing evidence, suggesting a potential role for gut dysbiosis in the pathogenesis of substance use disorders. Clinical evidence of gut dysbiosis in human subjects with substance use disorder as well as preclinical evidence of gut dysbiosis in animal models of drug addiction are discussed in detail. Additionally, we examine how changes in the gut microbiome and its metabolites may not only be a consequence of substance use disorders but may in fact play a role in mediating behavioral response to drugs of abuse. While much work still needs to be done, understanding the interplay of gut microbiome in substance use disorders may offers a promising avenue for future therapeutic development.

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Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice

Cited by 45 publications

References 86 publications

Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice

Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice

Alcohol or Gut Microbiota: Who Is the Guilty?

A potential role for the gut microbiome in substance use disorders

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