Gut microbiota and its metabolites – molecular mechanisms and management strategies in diabetic kidney disease

Mao, Zi-Hui; Gao, Zhong‐Xiuzi; Li, Dongwei; Liu, Zhangsuo; Wu, Peng

doi:10.3389/fimmu.2023.1124704

Cited by 14 publications

(11 citation statements)

References 154 publications

(116 reference statements)

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“…Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the final manifestation of chronic kidney disease, which was associated with a various molecular mechanisms such as activations of aryl hydrocarbon receptor [106][107][108][109][110], NF-κB [111,112] and Wnt/β-catenin [113][114][115] signalling pathways as well as dysbiosis of gut [116,117] and disorder of endogenous metabolite [118][119][120][121][122]. Kidney aging has been identified as a chronic process characterized by impaired renal function and structural changes in the tubular interstitium and glomerulus [123].…”

Section: Aging-related Renal Fibrosismentioning

confidence: 99%

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

Ren¹,

Miao²,

Wang³

et al. 2023

Aging and disease

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Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue fibrosis. Numerous clinical investigations have shown a correlation between the degree of liver and pulmonary fibrosis in patients and telomere length and mitochondrial DNA content, both of which are signs of aging. Aging involves the gradual loss of tissue function over time, which results in the loss of homeostasis and, ultimately, an organism's fitness. A major feature of aging is the accumulation of senescent cells. Senescent cells abnormally and continuously accumulate in the late stages of life, contributing to age-related fibrosis and tissue deterioration, among other aging characteristics. Furthermore, aging generates chronic inflammation, which results in fibrosis and decreases organ function. This finding suggests that fibrosis and aging are closely related. The transforming growth factorbeta (TGF-β) superfamily plays a crucial role in the physiological and pathological processes of aging, immune regulation, atherosclerosis, and tissue fibrosis. In this review, the functions of TGF-β in normal organs, aging, and fibrotic tissues is discussed: TGF-β signalling is altered with age and is an indicator of pathology associated with tissue fibrosis. In addition, this review discusses the potential targeting of noncoding.

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Section: Aging-related Renal Fibrosismentioning

confidence: 99%

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

Ren¹,

Miao²,

Wang³

et al. 2023

Aging and disease

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“…5d). Considering the close connection of the microbial-gut-kidney axis in the occurrence and development of DN [32,33]. Gut microorganisms might perhaps in uence the occurrence of immune and in ammatory responses as well as many various aspects of gut mucosa and gut bacterial structure and function.…”

Section: Modulation Of T-cell Types In Dn Rats By Acupuncture Treatmentmentioning

confidence: 99%

Uncovering the biological mechanism of acupuncture alleviating diabetic nephropathy through homeostasis regulation the of intestinal flora and T lymphocytes

Lu,

Li,

et al. 2023

Preprint

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Diabetic nephropathy (DN) is a major healthcare challenge in the management of diabetic patients.The aim of this study was to investigate the protective role of acupuncture treatment in the treatment of DN.After DN modelling, DN rats were treated with acupuncture (4 weeks) and diabetic metabolic parameters and urinary proteins were measured. Hematoxylin-Eosin (HE) staining and Periodic Acid-Schiff(PAS) staining were conducted to assess the degree of renal structural damage. Enzyme-linked immunosorbent assay (ELISA) was used to detect inflammatory factors mediated by renal T-lymphocyte polarization.Western Blotting (WB) was used to analyze the FOXP3/NF-κB signaling pathway. Composition of T-lymphocyte taxa was detected by flow cytometric analysis. Furtherment, the composition of intestinal microorganisms was detected by 16S rDNA sequencing to explore the effects of acupuncture treatment on the composition and structure of intestinal flora in DN rats.Herein, our results show that acupuncture treatment alleviates renal pathological changes, reduces expression of pro-inflammatory factors, and remodels T-lymphocyte homeostasis in DN rats. Detection of intestinal microorganisms showed that acupuncture improved the composition and structure of intestinal flora and up-regulated the content of probiotics. Our study reveals that remodeling of T-lymphocyte homeostasis through the microbial-gut-kidney axis and consequent inhibition of pro-inflammatory cytokine activation may be the underlying biological mechanism of acupuncture in the treatment of DN.

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“…The gut microbiota influences the host’s inflammatory state and immune system, which in turn affects the prognosis of disease. Moreover, the intestinal microbiota contributes to the progression of host diseases through its metabolites, including short chain fatty acids (SCFAs), bile acids, tryptophan, branched-chain amino acids, and uremic toxins [ 5 ]. With the development of research, attention has gradually been given to whether the gut microbiota has the ability to regulate ferroptosis.…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Mao,

Gao,

Pan

et al. 2024

Cell Death Discov.

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Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients and energy to the host, but also plays a crucial role in immune modulation and metabolic balance. In this review, we explore the metabolic pathways associated with ferroptosis and the impact of the gut microbiota on host metabolism. We subsequently summarize recent studies on the influence and regulation of ferroptosis by the gut microbiota and discuss potential mechanisms through which the gut microbiota affects ferroptosis. Additionally, we conduct a bibliometric analysis of the relationship between the gut microbiota and ferroptosis in the context of chronic kidney disease. This analysis can provide new insights into the current research status and future of ferroptosis and the gut microbiota.

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Gut microbiota and its metabolites – molecular mechanisms and management strategies in diabetic kidney disease

Cited by 14 publications

References 154 publications

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

Uncovering the biological mechanism of acupuncture alleviating diabetic nephropathy through homeostasis regulation the of intestinal flora and T lymphocytes

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

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