Gut microbiota and ionizing radiation-induced damage: Is there a link?

Yu, Yueqiu; Lin, Xin; Feng, Feiyang; Wei, Yuanyun; Wei, Shuang; Gong, Yaqi; Guo, Caimao; Wang, Qingyu; Shuai, Peimeng; Wang, Tiantian; Hui, Qing; Li, Guoqing; Liang, Yi

doi:10.1016/j.envres.2023.115947

Cited by 6 publications

(2 citation statements)

References 123 publications

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“…Its major advantages are as follows: (1) capable of dynamically analyzing the overall composition of metabolites, including feces, urine, blood, and secretions and cells of the body; (2) high accuracy, high sensitivity, and high throughput; and (3) based on multivariate statistical analysis methods, it can intuitively illustrate the pathological and physiological status of the research object, environmental factors, and the relationships between various groups of information, and obtain biomarkers [ 13 , 14 ]. This approach can explain the basic form of gut microbial metabolism and more accurately analyze the metabolic system, and consequently, the results obtained with this approach can help study the relationship between gut microbiota and the host [ [15] , [16] , [17] ].…”

Section: Discussionmentioning

confidence: 99%

Microbiome profiling and Co-metabolism pathway analysis in cervical cancer patients with acute radiation enteritis

Ma,

Zhao,

Zhou

2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Microbiome profiling and Co-metabolism pathway analysis in cervical cancer patients with acute radiation enteritis

Ma,

Zhao,

Zhou

2024

Heliyon

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“…Considerable gut microbiome variations must therefore be assumed between the animals in the two experiments. It has been well documented that a complete and functional gut microbiome may lower gastrointestinal radiosensitivity, and conversely that ionizing radiation adversely affects the gut microbiome [42][43][44].…”

Section: Acute Effects Of Total Body and Bone Marrow-spared Irradiationmentioning

confidence: 99%

Effects of Bone Marrow Sparing and TGF-β3 Treatment in Total Body Irradiation of C57BL/6J Mice

Hanson,

Vatne,

Edin

2024

Applied Biosciences

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Introduction: Mortality from acute radiation syndrome is frequently caused by hematopoietic or gastrointestinal radiotoxicity, the latter of which currently has no effective treatment. Transforming growth factor-beta 3 (TGF-β3) may decrease the severity of radiation-induced gastrointestinal damage in mice. In addition, treatment with TGF-β3 may alleviate radiation-induced fibrosis. Objectives: The current study aimed to investigate the effect of TGF-β3 treatment on acute and late radiotoxicity in whole body irradiated mice. Methods: C57BL/6J mice were total body irradiated with 8.5 Gy X-rays with or without shielding of one hind leg to alleviate hematopoietic radiotoxicity. The effects of intravenous TGF-β3 treatment were investigated. Body weight and pain expression were monitored. Intestine, lung, and liver tissues were preserved and analyzed. Alpha smooth muscle actin (α-SMA) expression in MRC-5 cells after 3.5 Gy X-irradiation combined with TGF-β3 treatment was analyzed using flow cytometry. Results: All total body irradiated animals died within ten days after irradiation. Ninety-three percent of femur-shielded mice survived until sampling or termination. No effect of TGF-β3 treatment was observed in either group. No increase in collagen content was detected in the lungs or liver from irradiated mice regardless of TGF-β3 treatment. In vitro, α-SMA expression increased synergistically after irradiation and TGF-β3 treatment. Conclusions: Shielding of the femur during total body irradiation decreased acute gastrointestinal radiation toxicity and increased survival. TGF-β3 treatment did not impact symptoms or survival. TGF-β3 treatment and irradiation increased α-SMA expression in MRC-5 cells synergistically.

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