Gut microbiota and health

Kc, Dilip; Sumner, Riley; Lippmann, Steven

doi:10.1080/00325481.2019.1662711

Cited by 43 publications

(28 citation statements)

References 8 publications

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“…The same finding is seen in the constituents of the gut microbiota[ 145 ]. It is indicated that overactivation of the NLRP1A receptor in mice leads to loss of butyrate-producing Clostridiales, with increased IL-18 and IFNγ production[ 146 ]. In final, it is observed the gene expression of NLRP1 in inflamed regions of the distal colon in patients with ulcerative colitis is increased, and a majority of bacterial operational taxonomic units were of the order Clostridiales, which is consist with the mechanistic observation in a human cohort[ 147 ] (Figure 1 ).…”

Section: Tryptophan Metabolismmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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Over the past two decades, it is improved gut microbiota plays an important role in the health and disease pathogenesis. Metabolites, small molecules produced as intermediate or end products of microbial metabolism, is considered as one of the major interaction way for gut microbiota with the host. Bacterial metabolisms of dietary substrates, modification of host molecules or bacteria are the major source of metabolites. Signals from microbial metabolites affect immune maturation and homeostasis, host energy metabolism as well as mucosal integrity maintenance. Based on many researches, the composition and function of the microbiota can be changed, which is also seen in the metabolite profiles of patients with inflammatory bowel disease (IBD). Additionally, some specific classes of metabolites also can trigger IBD. In this paper, definition of the key classes of microbial-derived metabolites which are changed in IBD, description of the pathophysiological basis of association and identification of the precision therapeutic modulation in the future are the major contents.

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Section: Tryptophan Metabolismmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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“…Anxiety-like behavior can be caused by a dysbiosis of the gut microbiota ( Carding et al, 2015 ; Kc et al, 2020 ). Rodent studies have demonstrated that intestinal microbiota disruption induced by stress ( Bharwani et al, 2017 ), or high-fat diet ( Bruce-Keller et al, 2017 ), or antibiotics ( Park et al, 2021 ) leads to anxiety-like behavior, which can be restored to normal by probiotic administration, including Escherichia coli ( Park et al, 2021 ) and B. longum ( Pinto-Sanchez et al, 2017 ).…”

Section: The Roles Of Microbiota On Depression Anxiety and Microrna E...mentioning

confidence: 99%

The Role of MicroRNA and Microbiota in Depression and Anxiety

Rosa

Formolo

et al. 2022

Front. Behav. Neurosci.

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Depression and anxiety are devastating disorders. Understanding the mechanisms that underlie the development of depression and anxiety can provide new hints on novel treatments and preventive strategies. Here, we summarize the latest findings reporting the novel roles of gut microbiota and microRNAs (miRNAs) in the pathophysiology of depression and anxiety. The crosstalk between gut microbiota and the brain has been reported to contribute to these pathologies. It is currently known that some miRNAs can regulate bacterial growth and gene transcription while also modulate the gut microbiota composition, suggesting the importance of miRNAs in gut and brain health. Treatment and prevention strategies for neuropsychiatric diseases, such as physical exercise, diet, and probiotics, can modulate the gut microbiota composition and miRNAs expressions. Nonetheless, there are critical questions to be addressed to understand further the mechanisms involved in the interaction between the gut microbiota and miRNAs in the brain. This review summarizes the recent findings of the potential roles of microbiota and miRNA on the neuropathology of depression and anxiety, and its potential as treatment strategies.

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“…More and more attention has been paid to the importance of intestinal flora in maintaining body health. Intestinal flora may be involved in the occurrence and development of depression, IBD, osteoporosis and other diseases (48,49). Therefore, the relationship between AS and intestinal flora is worthy of further discussion.…”

Section: Othersmentioning

confidence: 99%

Drug treatment of ankylosing spondylitis and related complications: an overlook review

Wang¹,

Zheng²,

Ma³

2020

Ann Palliat Med

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Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by back pain and progressive spinal stiffness. The prevalence of AS is 30 per 10,000 people. The patients often have complications or co-existing diseases, which may affect the choice of drugs and the treatment effects.However, the pathogenesis of AS is still controversial. Inflammation takes a key role in the occurrence and development of AS. Therefore, antiinflammation is crucial in the management of AS. The goals and principles of AS management is to achieve remission, control disease activity and improve the quality of the life of patients. What is more, drug therapy is still a primary part of AS management. Due to the heterogeneity of AS patients, the effect of conventional treatment is limited. There is evidence that multidisciplinary therapy (MDT) is of great value in drug selection and reasonable combination. To conclude and reach a better understanding, we took a brief overlook of the drug treatment of AS and its related complications.

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Gut microbiota and health

Cited by 43 publications

References 8 publications

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Role of metabolites derived from gut microbiota in inflammatory bowel disease

The Role of MicroRNA and Microbiota in Depression and Anxiety

Drug treatment of ankylosing spondylitis and related complications: an overlook review

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