Gut microbiota and calcium balance

Abstract

Microorganisms living on the surface and inside the human body play an important role in the physiological activities of the human body. The largest microecosystem in the human body is the gut microbiome. Calcium disorders are found in many diseases. For example, patients with chronic renal insufficiency present with secondary hyperparathyroidism, which is caused by a calcium imbalance in the body. In addition, calcium dysregulation may affect lipid metabolism in the liver through the calmodulator pathway, leading to cirrhosis, etc. Currently, a considerable number of probiotics have been proven to enhance the body’s absorption of calcium. This paper reviews the effects of intestinal flora and related factors such as short-chain fatty acids, estrogen, immune factors and vitamin D on calcium balance.

Different Approaches to Ergogenic, Pre-, and Probiotic Supplementation in Sports with Different Metabolism Characteristics: A Mini Review

“…By influencing the “lining” of the intestines, probiotic bacteria facilitate the absorption of electrolytes, controlling the state of hydration, and also improve the breakdown of proteins, fats and carbohydrates, modifying the nutritional state [ 69 ]. Much attention is also paid to the fact that bacteria produce vitamins, especially B vitamins, and enhance absorption of iron and calcium [ 70 , 71 ].…”

Raspberry polyphenols alleviate neurodegenerative diseases: through gut microbiota and ROS signals

“…151 Gut microbes can regulate calcium absorption and utilization by the body to help reduce the dysregulation of Ca 2+ levels. 152 The reduction of free Ca 2+ can be achieved by the human intestine through its utilization and conversion, avoiding the activation of PKCα and NOX4 proteins, which in turn controls the level of ROS. Quercetin regulates ROS production by inhibiting PKC protein expression and enzyme activity while inhibiting p47phox phosphorylation.…”

Associations of dietary factors and xenobiotic intake with faecal microbiota composition according to the presence of intestinal mucosa damage

“…The metabolism of calcium has been previously bidirectionally associated with shifts in the gut microbiota, with SCFAs playing key roles in these processes. 70,71 In this sense, SCFAs are capable of lowering pH in the intestinal environment, reducing calcium-phosphorus complexes and improving dietary calcium release and absorption. 72,73 An increased abundance of Coriobacteriaceae was detected in the control individuals with an intake of ≥120 g day −1 milk, ≥50 g day −1 red meat, ≥20 g day −1 fibre, ≥650 mg day −1 total polyphenols, ≥0.75 µg day −1 total PAH or ≥50 ng day −1 MeIQx.…”