Gut microbiota and allergic disease in children

Bridgman, Sarah L.; Kozyrskyj, Anita L.; Scott, James A.; Becker, Allan B.; Azad, Meghan B.

doi:10.1016/j.anai.2015.10.001

Cited by 44 publications

(47 citation statements)

References 72 publications

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“…Early microbial colonization is essential to infants' metabolic and immunological development (41). There is a direct link between microbial colonization and the risk of non-communicable diseases in later life, including allergies (42). After birth, the transfer of microbiota continues during lactation, and it is considered as the cause of differences in gut microbiota between exclusively breast-fed and formula-fed infants during the first month of life (43).…”

Section: Discussionmentioning

confidence: 99%

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

et al. 2020

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“…1,42 Definitive results await the accomplishment of multiple birth cohort studies with large sample sizes, long term follow up, and allergic outcomes that have been defined using carefully constructed and specific phenotypes. 43-45 …”

Section: Early Epidemiologic Studies Suggesting Effects Of Gut Microbmentioning

confidence: 99%

The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases

Johnson

Ownby

2017

Translational Research

123

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Among the many areas being revolutionized by the recent introduction of culture independent microbial identification techniques is investigation of the relationship between close contact with large animals, antibiotics, breast feeding, mode of birth, and other exposures during infancy as related to a reduced risk of asthma and allergic disease. These exposures were originally clustered under the “Hygiene Hypothesis” which has morphed into the “Microbiota Hypothesis”. This review begins by summarizing epidemiologic studies suggesting that the common feature of these allergy risk-related exposures is their influence on the founding and early development of a child's gut microbiota. Next studies using culture independent techniques are presented showing that the microbiota of children who have experienced the exposures of interest have altered gut microbiota. Finally, selected mouse and human studies are presented which begin to corroborate the protective exposures identified in epidemiologic studies by identifying mechanisms through which microbes can alter immune development and function. These microbially driven immune alterations demonstrate that microbial exposures in many cases could alter the risk of subsequent allergic disease and asthma. Hopefully a better understanding of how microbes influence allergic disease will lead to safe and effective methods for reducing the prevalence of all forms of allergic disease.

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“…Gut microbial dysbiosis is increasingly identified with allergic diseases in children . Interaction between the dysbiotic microbiota and allergic response to allergens plays an important role in allergic airway diseases .…”

Section: Introductionmentioning

confidence: 99%

“…Gut microbial dysbiosis is increasingly identified with allergic diseases in children. 7 Interaction between the dysbiotic microbiota and allergic response to allergens plays an important role in allergic airway diseases. 8 However, few studies address the impacts of specific gut microbiota involved in biochemical functions related to allergen sensitization on atopic diseases, particularly in childhood.…”

mentioning

confidence: 99%

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

Chiu

Cheng

Chiang

et al. 2019

Pediatric Allergy Immunology

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Background A comprehensive metabolomics‐based approach to address the impact of specific gut microbiota on allergen sensitization for childhood rhinitis and asthma is still lacking. Methods Eighty‐five children with rhinitis (n = 27) and with asthma (n = 34) and healthy controls (n = 24) were enrolled. Fecal metabolomic analysis with 1H‐nuclear magnetic resonance (NMR) spectroscopy and microbiome composition analysis by bacterial 16S rRNA sequencing were performed. An integrative analysis of their associations with allergen‐specific IgE levels for allergic rhinitis and asthma was also assessed. Results Amino acid, β‐alanine, and butanoate were the predominant metabolic pathways in the gut. Among them, amino acid metabolism was negatively correlated with the phylum Firmicutes, which was significantly reduced in children with rhinitis and asthma. Levels of histidine and butyrate metabolites were significantly reduced in children with rhinitis (P = 0.029) and asthma (P = 0.009), respectively. In children with asthma, a reduction in butyrate‐producing bacteria, including Faecalibacterium and Roseburia spp., and an increase in Clostridium spp. were negatively correlated with fecal amino acids and butyrate, respectively (P < 0.01). Increased Escherichia spp. accompanied by increased β‐alanine and 4‐hydroxybutyrate appeared to reduce butyrate production. Low fecal butyrate was significantly associated with increased total serum and mite allergen–specific IgE levels in children with asthma (P < 0.05). Conclusion A reduced fecal butyrate is associated with increased mite‐specific IgE levels and the risk of asthma in early childhood. Fecal β‐alanine could be a specific biomarker connecting the metabolic dysbiosis of gut microbiota, Clostridium and Escherichia spp., in childhood asthma.

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Gut microbiota and allergic disease in children

Cited by 44 publications

References 72 publications

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice

The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases

Gut microbial‐derived butyrate is inversely associated with IgE responses to allergens in childhood asthma

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