2021
DOI: 10.1016/j.lfs.2021.120060
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Gut microbiota: A potential therapeutic target for management of diabetic retinopathy?

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Cited by 15 publications
(4 citation statements)
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“…The gut microbiota could regulate the body’s glycolipids by participating in the body’s metabolism. Studies have shown that a long-term high-glucose-fat diet could cause disturbances in the intestinal environment, altering the composition, structure, and diversity of the microbiota [ 36 ]. In this study, the Alpha diversity index of the mice in the HFD group decreased, indicating that a high-glucose-fat diet could reduce the richness and diversity of gut microbes, which, in turn, could lead to an imbalance in the gut microbiota [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…The gut microbiota could regulate the body’s glycolipids by participating in the body’s metabolism. Studies have shown that a long-term high-glucose-fat diet could cause disturbances in the intestinal environment, altering the composition, structure, and diversity of the microbiota [ 36 ]. In this study, the Alpha diversity index of the mice in the HFD group decreased, indicating that a high-glucose-fat diet could reduce the richness and diversity of gut microbes, which, in turn, could lead to an imbalance in the gut microbiota [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…[109][110][111] An important benefit can be seen in the gut microbiome, which contributes to the low grade local and systemic inflammation modulated by metformin. 112,113 A study by Wu et al evaluated the effect of fecal transplant from metformin-treated subjects to germ free (GF) mice and found that the mice showed improved glucose tolerance due to biological pathways mediated by Bifidobacterium adolescentis species. 114 It has also been shown that metformin increases the level of SCFA and butyrate producing flora via selective inhibition of the bacterial folate cycle, complex I of the bacterial electron transport chain, and gluconeogenesis in bacteria that do not produce these molecules.…”
Section: Medications and Antioxidants Agents Modulate Flora In Diabet...mentioning
confidence: 99%
“…Early evidence has suggested the role of gut dysbiosis in developing and maintaining DR [ 225 , 226 , 227 ]. Although previous studies have reported antioxidant and anti-inflammatory benefits with polyphenol therapy in DR, to our knowledge, there are no studies evaluating the role of microbiota in the reported effects of polyphenol therapy in DR.…”
Section: Potential Interactions Among Polyphenols Probiotics and Gut ...mentioning
confidence: 99%