Gut microbiota: A potential therapeutic target for management of diabetic retinopathy?

Alarcón, Yempén, Rosa Elvira; Venzel, Raphaelly; Campos, Maria Clara Paulino; Oliveira, Larissa Pessoa de; Lins, Rodrigo Vásquez Dan; Pessoni, André Moreira; Fanaro, Gustavo Bernardes; Souza, Anderson de Oliveira; Calaza, Karin da Costa; Alves, José Luiz; Cavalcanti-Neto, Marinaldo Pacífico

doi:10.1016/j.lfs.2021.120060

Cited by 15 publications

(4 citation statements)

References 123 publications

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“…The gut microbiota could regulate the body’s glycolipids by participating in the body’s metabolism. Studies have shown that a long-term high-glucose-fat diet could cause disturbances in the intestinal environment, altering the composition, structure, and diversity of the microbiota [ 36 ]. In this study, the Alpha diversity index of the mice in the HFD group decreased, indicating that a high-glucose-fat diet could reduce the richness and diversity of gut microbes, which, in turn, could lead to an imbalance in the gut microbiota [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus paracasei JY062 Alleviates Glucolipid Metabolism Disorders via the Adipoinsular Axis and Gut Microbiota

Su,

Ren,

Zhang

et al. 2024

Nutrients

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Glycolipid metabolic disorders (GLMD) refer to a series of metabolic disorders caused by abnormal processes of glucose and lipid synthesis, decomposition, and absorption in the body, leading to glucose and lipid excess, insulin resistance, and obesity. Probiotic intervention is a new strategy to alleviate metabolic syndrome. Lactobacillus paracasei JY062 (L. paracasei JY062) was separated from the Tibet-fermented dairy products. The results demonstrated a strong ability to relieve blood glucose disorders, blood lipid disorders, and tissue damage. The LPH group had the best effect, significantly decreasing the total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), leptin, insulin, and free fatty acid (FFA) concentrations and increasing the high-density lipoprotein cholesterol, adiponectin, and GLP-1 level compared to HFD-group mice. L. paracasei JY062 could activate the APN-AMPK pathway, increased AdipoQ, AMPK GLUT-4, and PGC-1α mRNA expression and decreased SREBP-1c, ACC, and FAS mRNA expression. L. paracasei JY062 intervention decreased the relative abundance of harmful bacteria, increased the relative abundance of beneficial bacteria, and restored the imbalance of gut microbiota homeostasis caused by a high-glucose-fat diet. L. paracasei JY062 alleviated glucolipid metabolism disorders via the adipoinsular axis and gut microbiota. This study provided a theoretical basis for probiotics to ameliorate glucolipid metabolism disorders by regulating the adipoinsular axis.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus paracasei JY062 Alleviates Glucolipid Metabolism Disorders via the Adipoinsular Axis and Gut Microbiota

Su,

Ren,

Zhang

et al. 2024

Nutrients

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“…[109][110][111] An important benefit can be seen in the gut microbiome, which contributes to the low grade local and systemic inflammation modulated by metformin. 112,113 A study by Wu et al evaluated the effect of fecal transplant from metformin-treated subjects to germ free (GF) mice and found that the mice showed improved glucose tolerance due to biological pathways mediated by Bifidobacterium adolescentis species. 114 It has also been shown that metformin increases the level of SCFA and butyrate producing flora via selective inhibition of the bacterial folate cycle, complex I of the bacterial electron transport chain, and gluconeogenesis in bacteria that do not produce these molecules.…”

Section: Medications and Antioxidants Agents Modulate Flora In Diabet...mentioning

confidence: 99%

Composition of the gut microbiome, role of diet, lifestyle, and antioxidant therapies in diabetes mellitus and diabetic retinopathy

Oganov

Seddon

Zein

et al. 2023

European Journal of Ophthalmology

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The gut microbiome is a complex ecosystem in the gastrointestinal tract composed of trillions of bacteria, viruses, fungi, and protozoa. Disruption of this delicate ecosystem, formally called “dysbiosis”, has been linked to a variety of metabolic and inflammatory pathologies. Several studies have focused on abnormal microbiome composition and correlated these findings with the development of type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR). However, given the complexity of this ecosystem, the current studies are narrow in design and present variable findings. Composition of the gut microbiome in patients with DR significantly differs from patients with diabetes without retinopathy as well as from healthy controls. Additionally, the gut microbiome has been shown to modify effects of medication, diet, exercise, and antioxidant use on the development and progression of DR. In this paper, we present a comprehensive review of literature on the effect of oxidative stress, antioxidant therapies, and dysbiosis on DR.

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“…Early evidence has suggested the role of gut dysbiosis in developing and maintaining DR [ 225 , 226 , 227 ]. Although previous studies have reported antioxidant and anti-inflammatory benefits with polyphenol therapy in DR, to our knowledge, there are no studies evaluating the role of microbiota in the reported effects of polyphenol therapy in DR.…”

Section: Potential Interactions Among Polyphenols Probiotics and Gut ...mentioning

confidence: 99%

New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy

et al. 2023

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Diabetic retinopathy (DR) is a neurodegenerative and vascular pathology that is considered one of the leading causes of blindness worldwide, resulting from complications of advanced diabetes mellitus (DM). Current therapies consist of protocols aiming to alleviate the existing clinical signs associated with microvascular alterations limited to the advanced disease stages. In response to the low resolution and limitations of the DR treatment, there is an urgent need to develop more effective alternative therapies to optimize glycemic, vascular, and neuronal parameters, including the reduction in the cellular damage promoted by inflammation and oxidative stress. Recent evidence has shown that dietary polyphenols reduce oxidative and inflammatory parameters of various diseases by modulating multiple cell signaling pathways and gene expression, contributing to the improvement of several chronic diseases, including metabolic and neurodegenerative diseases. However, despite the growing evidence for the bioactivities of phenolic compounds, there is still a lack of data, especially from human studies, on the therapeutic potential of these substances. This review aims to comprehensively describe and clarify the effects of dietary phenolic compounds on the pathophysiological mechanisms involved in DR, especially those of oxidative and inflammatory nature, through evidence from experimental studies. Finally, the review highlights the potential of dietary phenolic compounds as a prophylactic and therapeutic strategy and the need for further clinical studies approaching the efficacy of these substances in DR management.

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Gut microbiota: A potential therapeutic target for management of diabetic retinopathy?

Cited by 15 publications

References 123 publications

Lactobacillus paracasei JY062 Alleviates Glucolipid Metabolism Disorders via the Adipoinsular Axis and Gut Microbiota

Lactobacillus paracasei JY062 Alleviates Glucolipid Metabolism Disorders via the Adipoinsular Axis and Gut Microbiota

Composition of the gut microbiome, role of diet, lifestyle, and antioxidant therapies in diabetes mellitus and diabetic retinopathy

New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy

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