Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Zuo, Wei-Fang; Pang, Qiwen; Yao, Lili; Zhang, Yang; Peng, Cheng; Huang, Wei; Han, Bo

doi:10.1016/j.jare.2023.05.011

Cited by 12 publications

(2 citation statements)

References 195 publications

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“…Based on the co-occurrence network analysis, Romboutsia and Turicibacter reveal complex interactions that could re ect a exible adaptation strategy to a variety of environmental states or perhaps indicate that their abundance is sensitive to the speci c conditions of each experiment. Similarly, the role of Dubosiella, Faecalibaculum, and Muribaculaceae in degrading complex carbohydrates (Zuo, et al 2023;Li, et al 2020) points to their functional diversity, but the extent to which these functions are leveraged in hydrocarbon-contaminated soils is not fully understood.…”

Section: Enrichment Of Bacterial Genera: Implications To Soil Ecosyst...mentioning

confidence: 99%

Evaluating Bacterial Population Changes and Ecological Dynamics in Oil-Impacted Soils Using 16S rRNA Amplicon Sequencing

Rahube,

Selvarajan,

Nduna

et al. 2024

Preprint

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Improper disposal of used motor oil is a prevalent issue in developing countries, leading to a notable contribution to environmental pollution. This study was conducted using the 16S rRNA targeted metagenomic approach, to assess the changes in bacterial population diversity and abundance at an oil contamination experimental site in Botswana. To demonstrate the impact of used motor oil is on the soil ecosystem, soil samples collected at different depths before and after treatment with used motor oil were subjected to total community DNA extraction and Illumina sequencing. The taxonomic bacterial composition data revealed statistically significant differences among the treatments and controls. A notable shift from Gram-negative to Gram-positive bacterial populations was observed following treatment with used motor oil. Prevotella and Aerococcus were among the few genera within the enriched Gram-positive bacteria that could be directly linked to biodegradation of the polycyclic aromatic hydrocarbons associated with oil contamination. Agricultural and biotechnologically important, plant-associated bacterial genera; Methylobacterium-methylorumbrum, Bradyrhizobium, and, Phyllobacterium significantly declined in relative abundance, thus demonstrating the negative impact of oil contamination. The results from this study, improves our understanding of the roles of indigenous soil bacteria, and can help in guiding future strategies for the sustainable management of contaminated soils globally in countries with similar climatic and ecological conditions.

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Section: Enrichment Of Bacterial Genera: Implications To Soil Ecosyst...mentioning

confidence: 99%

Evaluating Bacterial Population Changes and Ecological Dynamics in Oil-Impacted Soils Using 16S rRNA Amplicon Sequencing

Rahube,

Selvarajan,

Nduna

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The gut microbiota includes a large number of microorganisms that colonize the human gut, affecting the body’s digestive function, defense ability, susceptibility to autoimmune diseases and tumors, and the body’s response to disease-treating drugs ( 10 ). Probiotics can promote intestinal peristalsis and food digestion, inhibit the growth of pathogenic bacteria, decompose harmful substances, and enhance immunity.…”

Section: Relationship Between the Gut Microbiota And Gbmmentioning

confidence: 99%

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Zhang,

Hong,

et al. 2024

Front. Immunol.

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Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays a certain role in GBM, and can directly or indirectly affect the efficacy of immune checkpoint inhibitors (ICIs) in various ways. (1) The metabolites produced by gut microbiota directly affect the host’s immune homeostasis, and these metabolites can affect the function and distribution of immune cells, promote or inhibit inflammatory responses, affect the phenotype, angiogenesis, inflammatory response, and immune cell infiltration of GBM cells, thereby affecting the effectiveness of ICIs. (2) Some members of the gut microbiota may reverse T cell function inhibition, increase T cell anti-tumor activity, and ultimately improve the efficacy of ICIs by targeting specific immunosuppressive metabolites and cytokines. (3) Some members of the gut microbiota directly participate in the metabolic process of drugs, which can degrade, transform, or produce metabolites, affecting the effective concentration and bioavailability of drugs. Optimizing the structure of the gut microbiota may help improve the efficacy of ICIs. (4) The gut microbiota can also regulate immune cell function and inflammatory status in the brain through gut brain axis communication, indirectly affecting the progression of GBM and the therapeutic response to ICIs. (5) Given the importance of gut microbiota for ICI therapy, researchers have begun exploring the use of fecal microbiota transplantation (FMT) to transplant healthy or optimized gut microbiota to GBM patients, in order to improve their immune status and enhance their response to ICI therapy. Preliminary studies suggest that FMT may enhance the efficacy of ICI therapy in some patients. In summary, gut microbiota plays a crucial role in regulating ICIs in GBM, and with a deeper understanding of the relationship between gut microbiota and tumor immunity, it is expected to develop more precise and effective personalized ICI therapy strategies for GBM, in order to improve patient prognosis.

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Biological transformation of medicine and food homology hawthorn with Monascus ruber to enhance lipid-lowering function

Dong,

Cai,

Liao

et al. 2024

Food Bioscience

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Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Cited by 12 publications

References 195 publications

Evaluating Bacterial Population Changes and Ecological Dynamics in Oil-Impacted Soils Using 16S rRNA Amplicon Sequencing

Evaluating Bacterial Population Changes and Ecological Dynamics in Oil-Impacted Soils Using 16S rRNA Amplicon Sequencing

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Biological transformation of medicine and food homology hawthorn with Monascus ruber to enhance lipid-lowering function

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