2018
DOI: 10.1038/s41564-018-0306-4
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Gut microbiome structure and metabolic activity in inflammatory bowel disease

Abstract: The inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are multifactorial, chronic conditions of the gastrointestinal tract. While IBD has been associated with dramatic changes in the gut microbiota, changes in the gut metabolome -- the molecular interface between host and microbiota -- are less-well understood. To address this gap, we performed untargeted LC-MS metabolomic and shotgun metagenomic profiling of cross-sectional stool samples from discovery ( … Show more

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Cited by 1,197 publications
(1,344 citation statements)
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References 60 publications
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“…Further, many of the taxa we identified as being predictive of autoimmune disease were correlated with metabolites that have been previously found to be associated with autoimmunity and inflammation. Recent publications have identified a number of bile acids, triacylglycerols 66 , vitamin B, and acylcarnitine 60 metabolites altered in IBD compared with a control population, many of which we also found to be significantly associated with our most predictive taxa.…”
Section: Discussionsupporting
confidence: 55%
“…Further, many of the taxa we identified as being predictive of autoimmune disease were correlated with metabolites that have been previously found to be associated with autoimmunity and inflammation. Recent publications have identified a number of bile acids, triacylglycerols 66 , vitamin B, and acylcarnitine 60 metabolites altered in IBD compared with a control population, many of which we also found to be significantly associated with our most predictive taxa.…”
Section: Discussionsupporting
confidence: 55%
“…This generated 1, 785 stool samples, 651 intestinal biopsies, and 529 blood samples. In addition to multi-omics data (e.g., metatranscriptomics [22] and metabolomics [6,17]), we also included clinical information.…”
Section: Datamentioning
confidence: 99%
“…Thus, the microbiota-metabolites interactions are important to maintain the host health and wellbeing. Integrative data analysis of gut microbiome and metabolome can offer deep insights on the impact of lifestyle and dietary factors on chronic and acute diseases (e.g., autoimmune diseases, inflammatory bowel disease [5] , cancers [6] , type 2 diabetes and obesity [7] , cardiovascular disorders, and non-alcoholic fatty liver disease [8] ), and provide potential diagnostic and therapeutic targets [9] .…”
Section: Introductionmentioning
confidence: 99%