Gut microbiome perturbation and its correlation with tylosin pharmacokinetics in healthy and infected pigs
Eon-Bee Lee,
Ga-Yeong Lee,
Md Akil Hossain
et al.
Abstract:Tylosin, an antibiotic with a long history in treating respiratory bacterial infections, has unknown effects on the gut microbiota of healthy and infected pigs. The study aimed to investigate the effect of a therapeutic dose of tylosin on swine gut microbiota and explored the relationship between this effect and tylosin pharmacokinetics (PK). We also assessed whether changes in gut microbiota after tylosin administration differ between healthy animals (n = 7) and animals intranasally co-infected (n = 7) with
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