Gut microbiome in allogeneic HCT survivors: The insults are gone but the damage lingers

Abstract

The gut microbiome is an important regulator of health and disease. The report by Hino et al. suggests that damage to the microbiome, inflicted before and soon after allogeneic haematopoietic progenitor cell transplantation, does not heal by itself, most likely with consequences for late transplantation outcomes. Commentary on: Hino et al. Prolonged gut microbial alterations in post‐transplant survivors of allogeneic haematopoietic stem cell transplantation. Br J Haematol 2023;200:725‐737.

Gut microbiota plays pivotal roles in benign and malignant hematopoiesis

“…The disrupted balance of gut microbiota could persist for a long period after transplantation. 78,79 More and more evidence suggests that the metabolites of gut microbiota play a crucial role in the occurrence and progression of GVHD. The bacterial metabolites, such as butyrate and propionate, are essential for immunology regulation.…”

“…The disrupted balance of gut microbiota could persist for a long period after transplantation. 78 , 79 …”