Gut microbiome, diet and symptom interactions in irritable bowel syndrome

Tap, Julien; Störsrud, Stine; Nevé, Boris Le; Cotillard, Aurélie; Pons, Nicolas; Doré, Joël; Öhman, Lena; Törnblom, Hans; Derrien, Muriel; Simrén, Magnus

doi:10.1101/2020.02.25.964528

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Studies have confirmed that the body's homeostasis and the intestinal immune function depend on the balance of bacteria in different degrees, and once this balance is destroyed, it will lead to the occurrence of related diseases (Bruellman and Llorente, 2021;Han et al, 2021;Khan et al, 2021;Shute et al, 2021;Sun et al, 2021;Deng et al, 2022b;Hu et al, 2022). The dysregulation of gut microbiota can be caused by many factors, such as age (Du et al, 2021;Janiak et al, 2021), lifestyle (Pauer et al, 2021;Shin et al, 2021), dietary habits (Neumann et al, 2021;Tap et al, 2021;Yu et al, 2021), immunity (Foley et al, 2021;Hosseinkhani et al, 2021) and the use of antibiotics (Kang et al, 2021;Mcdonnell et al, 2021;Strati et al, 2021;Vicentini et al, 2021).…”

Section: Intestinal Microbiotamentioning

confidence: 99%

Crosstalk between gut microbiota and renal ischemia/reperfusion injury

Huang

Cao

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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Renal ischemia-reperfusion injury (IRI) is the main cause of acute kidney injury and the cause of rapid renal dysfunction and high mortality. In recent years, with the gradual deepening of the understanding of the intestinal flora, exploring renal IRI from the perspective of the intestinal flora has become a research hotspot. It is well known that the intestinal flora plays an important role in maintaining human health, and dysbiosis is the change in the composition and function of the intestinal tract, which in turn causes intestinal barrier dysfunction. Studies have shown that there are significant differences in the composition of intestinal flora before and after renal IRI, and this difference is closely related to the occurrence and development of renal IRI and affects prognosis. In addition, toxins produced by dysregulated gut microbes enter the bloodstream, which in turn exacerbates kidney damage. This article reviews the research progress of intestinal flora and renal IRI, in order to provide new treatment ideas and strategies for renal IRI.

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Section: Intestinal Microbiotamentioning

confidence: 99%

Crosstalk between gut microbiota and renal ischemia/reperfusion injury

Huang

Cao

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Food and nutraceuticals are important for the gastrointestinal microbiome composition of humans and other animals (Lanng et al, 2021). Poor-quality food items consumed as main meals were reported to relate to severe irritable bowel syndrome in humans, as an enrichment of gut microbiota with a function toward a specific type of hydrogen metabolism associated with animal carbohydrate metabolism were detected in these cases (Tap et al, 2021). The dietary glucose oxidase could inhibit harmful bacteria and promote beneficial bacteria, which could be related to the improvement of the growth performance and intestinal barrier function in chickens (Zhao et al, 2021).…”

Section: Diet Improves Meat Quality By Altering Gut Microbiotamentioning

confidence: 99%

“…The dietary glucose oxidase could inhibit harmful bacteria and promote beneficial bacteria, which could be related to the improvement of the growth performance and intestinal barrier function in chickens (Zhao et al, 2021). Eubacterium rectale subspecies harboring flagellin-encoding genes were associated with a predominantly meat-based diet (Tap et al, 2021). Two of the three E. rectale subspecies were found to be associated with lower gut microbial community diversity, higher host BMI, and higher fasting blood insulin levels (Costea et al, 2017).…”

Section: Diet Improves Meat Quality By Altering Gut Microbiotamentioning

confidence: 99%

Gut microbiota and meat quality

Chen

Leng

et al. 2022

Front. Microbiol.

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Sustainable meat production is important to providing safe and quality protein sources for humans worldwide. Intensive artificial selection and high energy input into the diet of many commercial animals for the last decade has significantly increased the daily gain of body weight and shortened the raising period, but unexpectedly decreased the meat quality. The gastrointestinal tract of animals harbors a diverse and complex microbial community that plays a vital role in the digestion and absorption of nutrients, immune system development, pathogen exclusion, and meat quality. Fatty acid composition and oxidative stress in adipose and muscle tissue influences meat quality in livestock and poultry. Recent studies showed that nutraceuticals are receiving increased attention, which could alter the intestinal microbiota and regulate the fat deposition and immunity of hosts to improve their meat quality. Understanding the microbiota composition, the functions of key bacteria, and the host-microbiota interaction is crucial for the development of knowledge-based strategies to improve both animal meat quality and host health. This paper reviews the microorganisms that affect the meat quality of livestock and poultry. A greater understanding of microbial changes that accompany beneficial dietary changes will lead to novel strategies to improve livestock and poultry meat product quality.

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Global prevalence and burden of meal-related abdominal pain

Colomier

Melchior

Algera

et al. 2022

BMC Med

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Background Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the global prevalence of meal-related abdominal pain and characterize this subgroup. Methods The data analyzed originated from the Internet survey component of the population-based Rome Foundation Global Epidemiology Study, completed in 26 countries (n = 54,127). Adult subjects were asked whether they had abdominal pain and how often this was meal-related. Respondents were categorized into “no,” “occasional,” and “frequent” meal-related abdominal pain groups based on 0%, 10–40%, and ≥50% of the pain episodes being meal-related, respectively. DGBI diagnoses, frequency of other GI symptoms, psychological distress, non-GI somatic symptoms, quality of life, and healthcare utilization were compared between groups. Mixed linear and ordinal regression was used to assess independent associations between psychological distress, non-GI somatic symptoms, quality of life, other GI symptoms, and meal-related abdominal pain. Results Overall, 51.9% of the respondents reported abdominal pain in the last 3 months, and 11.0% belonged to the group with frequent meal-related abdominal pain, which included more females and younger subjects. DGBI diagnoses were more common in subjects with frequent meal-related abdominal pain, and the frequency of several GI symptoms was associated with having more frequent meal-related abdominal pain. Having meal-related abdominal pain more frequently was also associated with more severe psychological distress, non-GI somatic symptoms, and a poorer quality of life. The group with frequent meal-related abdominal pain also more often consulted a doctor for bowel problems compared to the other groups of meal-related abdominal pain. Conclusion Reporting frequent meal-related abdominal pain is common across the globe and associated with other GI and non-GI somatic symptoms, psychological distress, healthcare utilization, and a poorer quality of life. Individuals who frequently experience meal-related abdominal pain also more frequently fulfill the diagnostic criteria for DGBI. Assessing meal-related symptoms in all DGBI patients could be of major importance to improve and individualize symptom management.

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Gut microbiome, diet and symptom interactions in irritable bowel syndrome

Cited by 3 publications

References 46 publications

Crosstalk between gut microbiota and renal ischemia/reperfusion injury

Crosstalk between gut microbiota and renal ischemia/reperfusion injury

Gut microbiota and meat quality

Global prevalence and burden of meal-related abdominal pain

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