Gut microbiome composition in lean patients with NASH is associated with liver damage independent of caloric intake: A prospective pilot study

Duarte, Sebastião Mauro Bezerra; Stefano, José Tadeu; Miele, Luca; Ponziani, Francesca Romana; Souza-Basqueira, Marcela de; Okada, L.S.R.R.; Costa, Fernando Henrique da Silva; Toda, Kyoko; Mazo, Daniel Ferraz de Campos; Sabino, Éster Cerdeira; Carrilho, F.J.; Gasbarrini, Antonio; Oliveira, Cláudia Pinto Marques Souza de

doi:10.1016/j.numecd.2017.10.014

Cited by 108 publications

(90 citation statements)

References 41 publications

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“…Meanwhile, Zhu et al noted a significant difference only in Escherichia , which was not appreciated in other studies. 7 To date, only one study has examined the gut microbiota in non-obese adults and noted a significant reduction in Faecalibacterium 19 , which is consistent with findings in obese NASH. 12, 18 However, Lactobacillus and Ruminococcus were reduced in non-obese NASH, similar to findings in non-obese NAFL, and consistent with findings that these genera may have a role in weight regulation.…”

Section: Human Gut Microbiome Profiles In Clinical Phenotypes Of Naflmentioning

confidence: 61%

“…In NAFL, comparison groups included healthy controls 9,8,10,11,15,16,18,23 and obese controls 21 . In NASH, comparison groups included healthy controls 9,10,12,13,18,19 , obese controls 7 , and NAFL 24,16 . In NAFLD-associated advanced fibrosis, comparison groups included healthy controls 20 and NAFLD without advanced fibrosis (stage<2) 17,24,22,16 .…”

Section: Figurementioning

confidence: 99%

“…In NAFLD-associated advanced fibrosis, comparison groups included healthy controls 20 and NAFLD without advanced fibrosis (stage<2) 17,24,22,16 . In NAFLD-related HCC, the comparison group included NAFLD-related cirrhosis without HCC 20 . + The fecal and serum metabolites listed are postulated to be derived from the gut microbiome. ± Two studies enrolled only non-obese subjects, in order to examine compositional changes in non-obese (“lean”) NAFL 15 and NASH 19 . Abbreviations : nonalcoholic fatty liver disease (NAFLD), nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). …”

Section: Figurementioning

confidence: 99%

“… ± Two studies enrolled only non-obese subjects, in order to examine compositional changes in non-obese (“lean”) NAFL 15 and NASH 19 . …”

Section: Figurementioning

confidence: 99%

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Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

Sharpton

Ajmera

Loomba

2019

Clinical Gastroenterology and Hepatology

136

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The gut microbiome, a diverse microbial community in the gastrointestinal tract, plays a pivotal role in the maintenance of health. The gut microbiome metabolizes dietary and host-derived molecules to produce bioactive metabolites, which have a wide array of effects on host metabolism and immunity. 'Dysbiosis' of the gut microbiome, commonly considered as perturbation of microbiome diversity and composition, has been associated with intestinal and extra-intestinal diseases, including nonalcoholic fatty liver disease (NAFLD). A number of endogenous and exogenous factors, such as nutritional intake and xenobiotic exposure, can alter the gut microbiome. We will review the evolving methods for studying the gut microbiome and how these profiling techniques have been utilized to further our understanding of the gut microbial community composition and functional potential in the clinical spectrum of NAFLD. We will highlight microbiome-host interactions that may contribute to the pathogenesis of NAFLD, with a primary focus on mechanisms related to the metabolic output of the gut microbiome. Finally, we will discuss potential therapeutic implications of the gut microbiome in NAFLD.

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Section: Human Gut Microbiome Profiles In Clinical Phenotypes Of Naflmentioning

confidence: 61%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

“… ± Two studies enrolled only non-obese subjects, in order to examine compositional changes in non-obese (“lean”) NAFL 15 and NASH 19 . …”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

Sharpton

Ajmera

Loomba

2019

Clinical Gastroenterology and Hepatology

136

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“…A number of cross‐sectional human studies have demonstrated an association between gut microbiota perturbation and the full clinical spectrum of NAFLD, including nonalcoholic fatty liver without steatohepatitis (NAFL), NASH, NAFLD‐related advanced fibrosis (fibrosis stage >2), and NAFLD‐related cirrhosis and hepatocellular carcinoma . Several of these studies were performed in pediatric cohorts, and an overwhelming majority of these studies used biomarker‐based sequencing to profile the gut microbiota.…”

Section: The Gut Microbiome In Nafldmentioning

confidence: 99%

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease

et al. 2018

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The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism of environmental, dietary, and host‐derived substrates, which produce bioactive metabolites. Perturbations to the composition and associated metabolic output of the gut microbiome have been associated with a number of chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). Here, we review the rapidly evolving suite of next‐generation techniques used for studying gut microbiome composition, functional gene content, and bioactive products and discuss relationships with the pathogenesis of NAFLD.

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Nonalcoholic Fatty Liver Disease Risk Factors in Latin American Populations: Current Scenario and Perspectives

Oliveira

Cotrim

Arrese

2019

Clinical Liver Disease

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http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/13-2-reading-oliveira a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/13-2-interview-arrese-english the interview with the author (English) http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/13-2-interview-arrese-spanish the interview with the author (Spanish) Answer questions and earn https://www.wileyhealthlearning.com/Activity/6692501/disclaimerspopup.aspx

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Gut microbiome composition in lean patients with NASH is associated with liver damage independent of caloric intake: A prospective pilot study

Cited by 108 publications

References 41 publications

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease

Nonalcoholic Fatty Liver Disease Risk Factors in Latin American Populations: Current Scenario and Perspectives

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