Gut microbiome can predict chemoradiotherapy efficacy in patients with esophageal squamous cell carcinoma

Sasaki, Takuma; Matsumoto, Yasunori; Murakami, Kentaro; Endo, Satoshi; Toyozumi, Takeshi; Otsuka, Ryota; Kinoshita, Kazuya; Hu, Jie; Iida, Shinichiro; Morishita, Hiroki; Nishioka, Yuri; Nakano, Akira; Uesato, Masaya; Matsubara, Hisahiro

doi:10.1007/s10388-023-01004-0

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Compared to healthy volunteers, salivary proteins before radiotherapy showed elevated levels of cystatin-C, lysozyme C, histatin-1, and proline-rich proteins [ 44 ]. The relative abundance of Lactobacillaceae in fecal samples showed a partial or complete response in patients with ESCC receiving chemoradiotherapy [ 45 ]. In mouse models of breast cancer and melanoma, intestinal fungi exhibit antitumor immune responses following radiation, whereas, bacteria exhibit the opposite responses.…”

Section: Discussionmentioning

confidence: 99%

Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma

He,

Li,

et al. 2024

Journal of Oral Microbiology

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Background The salivary microbiome may interact with chemoradiotherapy through dynamic changes in microbial composition and systemic immunity. We aimed to explore the association between the salivary microbiome and response to chemoradiotherapy in initially inoperable patients with local advanced esophageal squamous cell carcinoma (LAESCC). Methods Salivary and peripheral blood samples were collected before and after chemoradiotherapy. The microbiome and metabolic pathways were analyzed by 16S ribosomal RNA sequencing and liquid chromatography tandem mass spectrometry/Mass spectrometry analyses. Results The salivary microbiome exhibited characteristic variations between patients and healthy controls. A significant correlation was found between Prevotella_salivae, Saccharibacteria_TM7_G3_bacterium_HMT_351, and Veillonellaceae_G1_bacterium_HMT_129 and pathological complete response (pCR) in initially inoperable patients who underwent surgery. The PICRUSt suggested that immune diseases and cell motility were different in tumor compared to normal groups. KEGG enrichment analysis showed enriched lipid metabolism, signal transduction, and membrane transport in the tumor group. CD3+CD8 T cells, IL6, IL10, and IFNγ exhibited an increasing trend during the treatment process of chemoradiotherapy. Conclusions Our study demonstrated that variations in specific saliva taxa associated with host immunomodulatory cells and cytokines could be promising for early efficacy prediction of chemoradiotherapy in initially inoperable patients with LAESCC.

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Section: Discussionmentioning

confidence: 99%

Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma

He,

Li,

et al. 2024

Journal of Oral Microbiology

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Causal relationship between gut microbiota and risk of esophageal cancer: evidence from Mendelian randomization study

Wang,

Chen

et al. 2024

Aging

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Background: The causative implications remain ambiguous. Consequently, this study aims to evaluate the putative causal relationship between gut microbiota and Esophageal cancer (EC). Methods: The genome-wide association study (GWAS) pertaining to the microbiome, derived from the MiBioGen consortium-which consolidates 18,340 samples across 24 population-based cohorts-was utilized as the exposure dataset. Employing the GWAS summary statistics specific to EC patients sourced from the GWAS Catalog and leveraging the two-sample Mendelian randomization (MR) methodology, the principal analytical method applied was the inverse variance weighted (IVW) technique. Cochran’s Q statistic was utilized to discern heterogeneity inherent in the data set. Subsequently, a reverse MR analysis was executed. Results: Findings derived from the IVW technique elucidated that the Family Porphyromonadaceae (P = 0.048) and Genus Candidatus Soleaferrea (P = 0.048) function as deterrents against EC development. In contrast, the Genus Catenibacterium (P = 0.044), Genus Eubacterium coprostanoligenes group (P = 0.038), Genus Marvinbryantia (P = 0.049), Genus Ruminococcaceae UCG010 (P = 0.034), Genus Ruminococcus1 (P = 0.047), and Genus Sutterella (P = 0.012) emerged as prospective risk contributors for EC. To assess reverse causal effect, we used EC as the exposure and the gut microbiota as the outcome, and this analysis revealed associations between EC and seven different types of gut microbiota. The robustness of the MR findings was substantiated through comprehensive heterogeneity and pleiotropy evaluations. Conclusions: This research identified certain microbial taxa as either protective or detrimental elements for EC, potentially offering valuable biomarkers for asymptomatic diagnosis and prospective therapeutic interventions for EC.

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Gut microbiome can predict chemoradiotherapy efficacy in patients with esophageal squamous cell carcinoma

Cited by 2 publications

References 28 publications

Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma

Salivary microbiome is associated with the response to chemoradiotherapy in initially inoperable patients with esophageal squamous cell carcinoma

Causal relationship between gut microbiota and risk of esophageal cancer: evidence from Mendelian randomization study

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