Gut microbiome and non-alcoholic fatty liver disease

Roles of Traditional and Next-Generation Probiotics on Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review and Network Meta-Analysis

“…An imbalanced gut microbiome may lead to impaired gut barrier function and increased intestinal permeability, causing liver inflammation and damage [ 5 , 6 ]. Therefore, regulating the imbalanced gut microbiota using various types of probiotics has become an emerging therapeutic strategy aimed at restoring balance and improving histological conditions [ 6 , 7 ].…”

“…Well-established probiotics such as lactic acid bacteria and bifidobacteria primarily regulate gut flora balance and enhance intestinal immunity through oral administration, thereby effectively controlling disease progression [ 8 , 9 ]. Complementing these are prebiotics, non-digestible food components that serve as nourishment for probiotics, promoting their growth and activity [ 7 ]. Synbiotics combine both probiotics and prebiotics to synergistically maintain gut microbiota balance more efficiently [ 7 , 10 ].…”

“…Complementing these are prebiotics, non-digestible food components that serve as nourishment for probiotics, promoting their growth and activity [ 7 ]. Synbiotics combine both probiotics and prebiotics to synergistically maintain gut microbiota balance more efficiently [ 7 , 10 ]. Together, these constituents constitute the traditional probiotic system, which ensures gut health and equilibrium through intricate interactions.…”