Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking

Piacentino, Daria; Grant-Beurmann, Silvia; Vizioli, Carlotta; Li, Xiaobai; Moore, Carl A.; Ruiz‐Rodado, Victor; Lee, Mary R.; Joseph, Paule V.; Fraser, Claire M.; Weerts, Elise M.; Leggio, Lorenzo

doi:10.1038/s41398-021-01728-6

Cited by 14 publications

(11 citation statements)

References 85 publications

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“…The 16S rRNA sequencing results showed that the β -diversity of LC, YEL, and YEH was significantly higher than that of the AL group ( Supplementary Figures S1D,E ), with no significant difference among the three groups. Studies indicated that ethanol can significantly decrease the level of β-diversity, which is closely related to alterations in the gut microbiota ( Piacentino et al, 2021 ; Xia et al, 2021 ). In terms of gut microbiota composition, the ratio of Firmicutes to Bacteroidetes in the YE group was lower than that in the alcohol-induced model group ( Figure 4C ).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of yeast extract against alcohol-induced liver injury in rats

Lin

Wang

et al. 2023

Front. Microbiol.

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Oxidative stress, inflammatory response, and gut-liver axis dysbiosis have been suggested as the primarily involved in the pathogenesis of alcoholic liver injury. Previous research established that yeast extract (YE) has antioxidant, immune-boosting or microbiota-regulating properties. However, there is currently lack of information regarding the efficacy of YE on alcoholic liver injury. This study seeks to obtain data that will help to address this research gap using a Wistar male rat experimental model. Histologic and biochemical analysis results showed that the groups treated with both low-dose yeast extract (YEL) and high-dose yeast extract (YEH) had lower degrees of alcohol-induced liver injury. The abundance of Peptococcus and Ruminococcus reduced in the low-dose yeast extract (YEL) group, while that of Peptococcus, Romboutsia, Parasutterella, and Faecalibaculum reduced in the high-dose (YEH) group. Furthermore, Spearman analysis showed that the gut microbes were significantly associated with several liver-related indicators. For the analysis of differential metabolites and enriched pathways in the YEL group, the abundance of lysophosphatidylcholine (16:0/0:0) significantly increased, and then the levels of histamine, adenosine and 5′ -adenine nucleotide were remarkedly elevated in the YEH group. These findings suggest that both high and low doses of YE can have different protective effects on liver injury in alcoholic liver disease (ALD) rats, in addition to improving gut microbiota disorder. Besides, high-dose YE has been found to be more effective than low-dose YE in metabolic regulation, as well as in dealing with oxidative stress and inflammatory responses.

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Section: Discussionmentioning

confidence: 99%

Protective effects of yeast extract against alcohol-induced liver injury in rats

Lin

Wang

et al. 2023

Front. Microbiol.

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“…The gut microbiome consists of trillions of bacteria which have a critical role in host’s health ( Huang et al., 2020 ; Khan et al., 2020 ; Abdullaeva et al., 2021 ; Piacentino et al., 2021 ). Firmicutes and Bacteroidetes are the two dominant bacterial phyla in human gut ( Guan et al., 2021 ; Kameli et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Bai

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveAlthough many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression.MethodsMajor depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors.ResultsFinally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs.ConclusionsOur results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression via affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.

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“…predictions [141]. However, it must be noted that ITS prediction accuracy is much lower than 16s prediction accuracy [101].…”

Section: Discussionmentioning

confidence: 89%

The Landscape of Maize-Associated Bacteria and Fungi Across the United States

Schultz¹,

Desai²,

Wallace³

2023

Preprint

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The maize microbiome consists of microbes that are associated with plants, and can be shaped by the host plant, the environment, and microbial partners, some of which can impact plant performance. We used a public dataset to analyze bacteria and fungi in the soil, rhizosphere, roots, and leaves of commercial maize at 30 locations across the US. We found that both tissue type and location had significant effects on community structure and makeup, although the patterns differed in bacteria and fungi based on tissue type. We also found many differences in predicted microbial gene pathways between tissues, with location also shaping predicted functional gene profiles. We found a pattern of potential interaction between fungi and bacteria, and potential intra-kingdom mutualism, in microbiome networks. The robustness of these networks was dependent upon tissue, with endophytes in leaves and roots showing significantly higher natural connectivity. Within a tissue, this connectivity was relatively stable across locations. We identified environment and soil characteristics that may impact tissue specific microbial abundance. Sulfate level in the soil was positively correlated with Proteobacteria abundance, but negatively correlated with Firmicutes abundance in the roots and leafs. Ascomycota appears to be affected by different environmental variables in each tissue. We also identified gene functions and enzymes which may be necessary to allow microbes to transition across compartments and become endophytes.

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Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking

Cited by 14 publications

References 85 publications

Protective effects of yeast extract against alcohol-induced liver injury in rats

Protective effects of yeast extract against alcohol-induced liver injury in rats

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

The Landscape of Maize-Associated Bacteria and Fungi Across the United States

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