Gut microbial diversity during pregnancy and early infancy: an exploratory study in the Indian population

Kumbhare, Shreyas V.; Patangia, Dhrati; Mongad, Dattatray S.; Bora, Abhijeet; Bavdekar, Ashish; Shouche, Yogesh S.

doi:10.1093/femsle/fnaa022

Cited by 8 publications

(11 citation statements)

References 34 publications

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“…To assess differences in diversity within samples, the Shannon Index alpha diversity metric was used as a measure of richness and evenness (Whittaker, 1972). Consistent with previous studies (DiGiulio et al , 2015; Faucher et al , 2020; Kumbhare et al , 2020), alpha diversity was similar throughout pregnancy (p=0.60) and across all sample time points including 6 months post-partum (p=0.057; Fig. S1).…”

Section: Resultssupporting

confidence: 89%

“…One of the first studies of the gut microbiome during pregnancy reported an increase in differences in overall community composition between samples (beta diversity) and a decrease in community richness within samples (alpha diversity) in otherwise normal pregnant individuals during the third trimester of pregnancy compared to the first (Koren et al, 2012). In contrast, others have found the maternal gut microbiota to be stable over the course of pregnancy (DiGiulio et al, 2015;Faucher et al, 2020;Kumbhare et al, 2020). Even fewer studies have investigated pregnancy-associated maternal microbial shifts in the context of pregnancy complications like excessive pre-pregnancy body mass index (pBMI) or gestational weight gain (GWG) (Collado et al, 2008;Santacruz et al, 2010;Stanislawski et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…No reuse allowed without permission. (DiGiulio et al, 2015;Faucher et al, 2020;Kumbhare et al, 2020). Even fewer studies have investigated pregnancy-associated maternal microbial shifts in the context of pregnancy complications like excessive pre-pregnancy body mass index (pBMI) or gestational weight gain (GWG) (Collado et al, 2008;Santacruz et al, 2010;Stanislawski et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Kennedy

Plagemann

Sommer

et al. 2022

Preprint

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Shifts in the gut microbiome have been implicated in mediating maternal metabolic adaptations to pregnancy. We investigated the impact of pre-pregnancy BMI (pBMI) and gestational weight gain (GWG) on pregnancy-associated remodeling of the maternal gut microbiome and infant colonization, and whether previous pregnancies modulated observed associations. We found that the gut microbiota of participants with higher pBMI changed less over the course of pregnancy in primiparous, but not multiparous participants This suggests that previous pregnancies may have persistent impacts on maternal microbiotal adaptations to pregnancy. This ecological memory appears to be passed to the next generation, as parity impacted infant microbial composition of first-pass meconium and modulated the impact of maternal GWG on the infant gut microbiome. This work supports a role for the gut microbiome in maternal adaptations to pregnancy and highlights parity as a key consideration for studies of the microbiome in pregnancy and infants.

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Section: Resultssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Kennedy

Plagemann

Sommer

et al. 2022

Preprint

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“…A total of 16 studies comprised of 1007 individuals including Chinese ( n =636), Indian ( n =248) and Malay ( n =123) ancestry were included in this meta-analysis ( and S1) [33–47]. A relatively balanced number of studies utilized the V3-V4 and V4 region, and most of these studies utilised a Qiagen-based DNA extraction kit (Fig.…”

Section: Resultsmentioning

confidence: 99%

Geographical separation and ethnic origin influence the human gut microbial composition: a meta-analysis from a Malaysian perspective

et al. 2021

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Ethnicity is consistently reported as a strong determinant of human gut microbiota. However, the bulk of these studies are from Western countries, where microbiota variations are mainly driven by relatively recent migration events. Malaysia is a multicultural society, but differences in gut microbiota persist across ethnicities. We hypothesized that migrant ethnic groups continue to share fundamental gut traits with the population in the country of origin due to shared cultural practices despite subsequent geographical separation. To test this hypothesis, the 16S rRNA gene amplicons from 16 studies comprising three major ethnic groups in Malaysia were analysed, covering 636 Chinese, 248 Indian and 123 Malay individuals from four countries (China, India, Indonesia and Malaysia). A confounder-adjusted permutational multivariate analysis of variance (PERMANOVA) detected a significant association between ethnicity and the gut microbiota (PERMANOVA R 2=0.005, pseudo-F=2.643, P=0.001). A sparse partial least squares – discriminant analysis model trained using the gut microbiota of individuals from China, India and Indonesia (representation of Chinese, Indian and Malay ethnic group, respectively) showed a better-than-random performance in classifying Malaysian of Chinese descent, although the performance for Indian and Malay were modest (true prediction rate, Chinese=0.60, Indian=0.49, Malay=0.44). Separately, differential abundance analysis singled out Ligilactobacillus as being elevated in Indians. We postulate that despite the strong influence of geographical factors on the gut microbiota, cultural similarity due to a shared ethnic origin drives the presence of a shared gut microbiota composition. The interplay of these factors will likely depend on the circumstances of particular groups of migrants.

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“…Elucidating the relationship between microbiome composition and pregnancy in human subject research is challenging. Studies are often characterized by small sample sizes [15], cross-sectional or sparse longitudinal sampling [16], and present challenges in controlling for confounding factors. Interpersonal variation in diet has a particularly large impact on gut microbiota composition in human studies [17], and differences in maternal diet during pregnancy have been shown to influence the infant gut microbiome [18].…”

Section: Introductionmentioning

confidence: 99%

Remodeling of the maternal gut microbiome during pregnancy is shaped by parity

Berry

Pierdon

Misic

et al. 2020

Preprint

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BackgroundThe maternal microbiome has emerged as an important factor in gestational health and outcome and is associated with risk of preterm birth and offspring morbidity. Epidemiological evidence also points to successive pregnancies – referred to as maternal parity – as a risk factor for preterm birth, infant mortality, and impaired neonatal growth. Despite the fact that both the maternal microbiome and parity are linked to maternal-infant health, the impact of parity on the microbiome remains largely unexplored, in part due to the challenges of studying parity in humans.ResultsUsing synchronized pregnancies and dense longitudinal monitoring of the microbiome in pigs, we describe a microbiome trajectory during pregnancy and determine the extent to which parity modulates this trajectory. We show that the microbiome changes reproducibly during gestation and that this remodeling occurs more rapidly as parity increases. At the time of parturition, parity was linked to the relative abundance of several bacterial species, including Treponema bryantii, Lactobacillus amylovorus, and Lactobacillus reuteri. Strain tracking carried out in 18 maternal-offspring ‘quadrads’ – each consisting of one mother sow and three piglets – linked maternal parity to altered levels of Akkermansia muciniphila, Prevotella stercorea, and Campylobacter coli in the infant gut 10 days after birth.ConclusionsCollectively, these results identify parity as an important environmental factor that modulates the gut microbiome during pregnancy and highlight the utility of a swine model for investigating the microbiome in maternal-infant health. In addition, our data show that the impact of parity extends beyond the mother and is associated with alterations in the community of bacteria that colonize the offspring gut early in life. The bacterial species we identified as parity-associated in the mother and offspring have been shown to influence host metabolism in other systems, raising the possibility that such changes may influence host nutrient acquisition or utilization. These findings, taken together with our observation that even subtle differences in parity are associated with microbiome changes, underscore the importance of considering parity in the design and analysis of human microbiome studies during pregnancy and in infants.

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Gut microbial diversity during pregnancy and early infancy: an exploratory study in the Indian population

Cited by 8 publications

References 34 publications

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Geographical separation and ethnic origin influence the human gut microbial composition: a meta-analysis from a Malaysian perspective

Remodeling of the maternal gut microbiome during pregnancy is shaped by parity

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