Gut microbial differences in breast and prostate cancer cases from two randomised controlled trials compared to matched cancer-free controls

Smith, Kristen S.; Frugé, Andrew D.; Pol, William Van Der; Caston, Nicole E.; Morrow, Casey D.; Demark‐Wahnefried, Wendy; Carson, Tiffany L.

doi:10.3920/bm2020.0098

Cited by 10 publications

(14 citation statements)

References 53 publications

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“…In this study, we identified the low rate of the order Lactobacillales and the high rate of the order Clostridiales observed in LD-fed mice. A recent study to compare fecal microbiota of patients with newly diagnosed treatment-naïve overweight and obese breast cancer or PCa (BMI > 25 kg/m 2 ) and matched controls showed that several bacteria within the order Clostridiales were significantly different in PCa cases compared with healthy controls [37]. In particular, Lachnospiraceae and Ruminococcaceae genera were highly abundant in patients with PCa compared with cancer-free controls [37].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study to compare fecal microbiota of patients with newly diagnosed treatment-naïve overweight and obese breast cancer or PCa (BMI > 25 kg/m 2 ) and matched controls showed that several bacteria within the order Clostridiales were significantly different in PCa cases compared with healthy controls [37]. In particular, Lachnospiraceae and Ruminococcaceae genera were highly abundant in patients with PCa compared with cancer-free controls [37]. Recently, Pernigoni et al developed two mouse models to assess the effect of commensal gut microbiota on castration-resistant PCa (CRPC) progression [17].…”

Section: Discussionmentioning

confidence: 99%

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Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Sato

Narita

Ishida

et al. 2022

IJMS

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Lard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets (LD) enriched in saturated and monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression with weight gain compared with a fish oil diet (FOD). High gut microbial divergency resulted from difference in diets, and the abundance of several bacterial species, such as in the orders Clostridiales and Lactobacillales, was markedly altered in the feces of LD- or FOD-fed mice. The proportion of the order Lactobacillales in the gut was negatively involved in SMFA-induced body weight gain and PCa progression. We found the modulation of lipid metabolism and cholesterol biosynthesis pathways with three and seven commonly up- and downregulated genes in PCa tissues, and some of them correlated with the abundance of the order Lactobacillales in mouse gut. The expression of sphingosine 1-phosphate receptor 2, which is associated with the order Lactobacillales and cancer progression in mouse models, was inversely associated with aggressive phenotype and weight gain in patients with PCa using the NCBI Gene Expression Omnibus database. Therefore, SMFA may promote PCa progression with the abundance of specific gut microbial species and overexpression of lipogenic genes in PCa. Therapeutics with alteration of gut microbiota and candidate genes involved in diet-induced PCa progression may be attractive in PCa.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Sato

Narita

Ishida

et al. 2022

IJMS

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“…Actually, it has been shown that the gut microbiota is associated with the development of hepatocellular carcinoma [24] . Different features of the gut microbiota have been observed between prostate cancer patients and benign prostatic hypertrophy, while the former has presented a higher prevalence of Bacteroides massiliensis compared to cases of benign prostatic hypertrophy [25] . Furthermore, the fecal microbiota of breast cancer and prostate cancer patients differs from that of control individuals [26] .…”

Section: Gut-cancer Axis In Carcinogenesismentioning

confidence: 99%

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Sawamura¹,

Taniguchi²,

Ikeda³

et al. 2022

J Transl Genet Genom

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The potentially powerful impact of microbiota has attracted much attention. For example, dysbiosis of the gut microbiota could be linked to various cancers. It is probable that DNA damage and DNA repair impairment due to inflammation from gut dysbiosis would be of importance in carcinogenesis and/or preventing carcinogenesis. In fact, the signature of the gut microbiome has been shown to be associated with responses and/or successful survival rate to certain immune-blockade therapy in several cancers. Conversely, living cells have to cope with the danger of reactive oxygen species (ROS) disturbing the integrity of biomolecules, which can eventually lead to carcinogenesis if otherwise untreated. Gut microbiota could modulate considerable levels of ROS and oxidative damage. Interestingly, an anti-proliferative family (APRO) characterized by several immediate early responsive gene products might be deeply involved in the mechanism of carcinogenesis. It has been described that APRO proteins also participate in a variety of cellular processes including cell division, DNA repair, and mRNA stability. The biological function of APRO proteins seems to be quite complicated; however, they might be a key modulator of microRNAs (miRNAs) for post-transcriptional regulation. The next generation of therapy would likely contain strategies for modifying the redox background as well as the regulation of ROS in cells and/or for better DNA repair machinery with the APRO proteins via the modulation of miRNA-derived post-transcriptional regulation in a sustainable manner. Given the important function of the gut microbiota in balancing the immune network, carcinogenesis could therefore be prevented by suitable gut microbiota via the roles of APRO proteins. Consequently, probiotics might play a key role in the modulation of gut immune system in keeping healthy and/or preventing cancers.

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“…Smith included the fecal microflora of 22 patients with overweight breast cancer or PCa (BMI > 25 kg/m2) and 22 controls. It was found that the β-diversity index of PCa was significantly different from that of the control group, and the abundance of Tissierellaceae , Lachnospira , and Ruminococcaceae was higher ( 29 ).…”

Section: Introductionmentioning

confidence: 96%

Potential role of gut microbiota in prostate cancer: immunity, metabolites, pathways of action?

et al. 2023

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The gut microbiota helps to reveal the relationship between diseases, but the role of gut microbiota in prostate cancer (PCa) is still unclear. Recent studies have found that the composition and abundance of specific gut microbiota are significantly different between PCa and non-PCa, and the gut microbiota may have common and unique characteristics between different diseases. Intestinal microorganisms are affected by various factors and interact with the host in a variety of ways. In the complex interaction model, the regulation of intestinal microbial metabolites and the host immune system is particularly important, and they play a key role in maintaining the ecological balance of intestinal microorganisms and metabolites. However, specific changes in the composition of intestinal microflora may promote intestinal mucosal immune imbalance, leading to the formation of tumors. Therefore, this review analyzes the immune regulation of intestinal flora and the production of metabolites, as well as their effects and mechanisms on tumors, and briefly summarizes that specific intestinal flora can play an indirect role in PCa through their metabolites, genes, immunity, and pharmacology, and directly participate in the occurrence, development, and treatment of tumors through bacterial and toxin translocation. We also discussed markers of high risk PCa for intestinal microbiota screening and the possibility of probiotic ingestion and fecal microbiota transplantation, in order to provide better treatment options for clinic patients. Finally, after summarizing a number of studies, we found that changes in immunity, metabolites.

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Gut microbial differences in breast and prostate cancer cases from two randomised controlled trials compared to matched cancer-free controls

Cited by 10 publications

References 53 publications

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Potential role of gut microbiota in prostate cancer: immunity, metabolites, pathways of action?

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