2018
DOI: 10.1002/bit.26793
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Gut–liver on a chip toward an in vitro model of hepatic steatosis

Abstract: Hepatic steatosis is a process of abnormal lipid deposition within the liver cells, often caused by excessive alcohol uptake or obesity. A conventional in vitro model for hepatic steatosis uses a liver cell culture, treated with fatty acids and measures accumulation of lipids within the cells. This model does not recapitulate the complex process of absorption and metabolism of digestive lipids. Here, we introduce a gut-liver chip, which mimics the gut absorption and hepatic metabolism in a microfluidic chip. A… Show more

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Cited by 83 publications
(89 citation statements)
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References 53 publications
(86 reference statements)
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“…Steatosis was quantified after treatment with α-lipolic acid (ALA), butyrate, and tumor necrosis factor (TNF)-α. ALA decreased TAG accumulation in both chips and 2D cultures. (24,28) Butyrate decreased steatosis by enhancing intestinal barrier function and decreasing TAG accumulation in hepatocytes. (29,30) TNF-α induced steatosis by affecting intestines, increasing steatosis in chip-based studies, but not in 2D monolayers.…”
Section: Liver Disease-on-a-chip Modelsmentioning
confidence: 95%
See 3 more Smart Citations
“…Steatosis was quantified after treatment with α-lipolic acid (ALA), butyrate, and tumor necrosis factor (TNF)-α. ALA decreased TAG accumulation in both chips and 2D cultures. (24,28) Butyrate decreased steatosis by enhancing intestinal barrier function and decreasing TAG accumulation in hepatocytes. (29,30) TNF-α induced steatosis by affecting intestines, increasing steatosis in chip-based studies, but not in 2D monolayers.…”
Section: Liver Disease-on-a-chip Modelsmentioning
confidence: 95%
“…(D) A reversibly and irreversibly injured ALD model where the development of fibrosis can be seen. Reprinted (A) with permission from Public Library of Science, (B) from Baishideng Publishing Group, (C) from John Wiley & Sons, and (D) from Royal Society of Chemistry …”
Section: Liver Disease‐on‐a‐chip Modelsmentioning
confidence: 99%
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“…Lee and Sung [69] have produced a model mimicking the absorption of fatty acids to assess the interaction between the two tissues, allowing assessment of the multifactorial systems involved in hepatic steatosis, or fatty liver disease. There are many components to hepatic steatosis and the mechanisms of disease are still not fully understood.…”
Section: Cellular Impedance In Understanding the Gut/liver Axismentioning
confidence: 99%