Gut inflammation exacerbates high-fat diet induced steatosis by suppressing VLDL-TG secretion through HNF4α pathway

Li, Ping; Chen, Xiu; Dong, Minglei; Luo, Jun; Lu, Shuanghui; Chen, Mingyang; Zhang, Yingqiong; Zhou, Hui; Jiang, Huidi

doi:10.1016/j.freeradbiomed.2021.06.027

Cited by 12 publications

(6 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The accumulation of triglyceride and T-CHO in hepatocytes could lead to hepatic steatosis. 39 The AST@WPI-Gal and AST@TPP-WPI-Gal treatment significantly decreased the liver index (Fig. 5g), triglyceride (Fig.…”

Section: Resultsmentioning

confidence: 82%

Hepatic parenchymal cell and mitochondrial-targeted astaxanthin nanocarriers for relief of high fat diet-induced nonalcoholic fatty liver disease

Che

Song

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 82%

Hepatic parenchymal cell and mitochondrial-targeted astaxanthin nanocarriers for relief of high fat diet-induced nonalcoholic fatty liver disease

Che

Song

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…[ 122 ] DSS‐induced colitis also reportedly reduced the expression of microsomal TG transfer protein and apolipoprotein B by inhibiting the hepatocyte nuclear factor 4α pathway, thus suppressing the secretion of VLDL‐TG and worsening high‐fat diet‐induced steatosis in mice. [ 123 ] These studies support that a vicious cycle is formed once homeostasis of the gut‐liver axis is destroyed.…”

Section: Meat and Liver Health (Gut‐liver Axis)mentioning

confidence: 74%

Reconsidering Meat Intake and Human Health: A Review of Current Research

Xie

Cai

et al. 2022

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Meat consumption is gradually increasing and its impact on health has attracted widespread attention, resulting in epidemiological studies proposing a reduction in meat and processed meat intake. This review briefly summarizes recent advances in understanding the effects of meat or processed meat on human health, as well as the underlying mechanisms. Meat consumption varies widely among individuals, populations, and regions, with higher consumption in developed countries than in developing countries. However, increasing meat consumption may not be the main cause of increasing incidence of chronic disease, since the development of chronic disease is a complex physiological process that involves many factors, including excessive total energy intake and changes in food digestion processes, gut microbiota composition, and liver metabolism. In comparison, unhealthy dietary habits and a sedentary lifestyle with decreasing energy expenditure are factors more worthy of reflection. Meat and meat products provide high‐value protein and many key essential micronutrients. In short, as long as excessive intake and overprocessing of meats are avoided, meat remains an indispensable source of nutrition for human health.

show abstract

“…Given that HNF4 α acts as a transcriptional activator of the Mttp and Apob genes in mammals [ 28 , 29 ], we further explored the effect of betaine addition on HNF4 α expression in L8824 cells. We found that the protein level of HNF4 α was also affected by high-fat treatment and betaine supplementation in the same way as MTTP and ApoB.…”

Section: Discussionmentioning

confidence: 99%

Betaine Alleviates High-Fat Diet Induced Excessive Lipid Deposition in Gibel Carp Hepatopancreas and L8824 Cells by Enhancing VLDL Secretion through HNF4α/MTTP Pathway

Dong,

Wang,

Zhao

et al. 2024

Aquaculture Nutrition

View full text Add to dashboard Cite

Betaine, a methyl donor, plays a crucial role in lipid metabolism. Previous studies have shown that appropriate betaine supplementation in a high-fat diet reduces triglycerides (TG) of serum and hepatopancreas in fish. However, the underlying mechanism remains unclear. This study examined whether betaine can enhance the secretion of very low-density lipoprotein (VLDL) and sought to identify the specific mechanisms through which this enhancement occurs. A lipid accumulation model was established in gibel carp and L8824 cells using a high-fat diet and oleic acid, respectively. Different doses of betaine (1, 4, and 16 g/kg in the diet; 400 μmol in cell culture) were administered, and measurements were taken for lipid deposition, gene expression of HNF4α, MTTP, and ApoB, as well as the regulation of Mttp and Apob promoters by HNF4α. The results showed that betaine supplementation mitigated lipid droplet accumulation, TG levels, and VLDL production induced by the high-fat diet in gibel carp hepatopancreas and L8824 cells. Moreover, betaine not only increased VLDL content in the cell culture supernatant but also reversed the inhibitory effects of the high-fat diet on protein expression of MTTP, ApoB, and HNF4α in both gibel carp hepatopancreas and L8824 cells. Additionally, HNF4α exhibits transactivating activity on the promoter of Mttp in gibel carp. These findings suggest that betaine supplementation exerts its effects through the HNF4α/MTTP/ApoB pathway, promoting the assembly and secretion of VLDL and effectively reducing lipid accumulation in the hepatopancreas of farmed gibel carp fed a high-fat diet.

show abstract

Gut inflammation exacerbates high-fat diet induced steatosis by suppressing VLDL-TG secretion through HNF4α pathway

Cited by 12 publications

References 46 publications

Hepatic parenchymal cell and mitochondrial-targeted astaxanthin nanocarriers for relief of high fat diet-induced nonalcoholic fatty liver disease

Hepatic parenchymal cell and mitochondrial-targeted astaxanthin nanocarriers for relief of high fat diet-induced nonalcoholic fatty liver disease

Reconsidering Meat Intake and Human Health: A Review of Current Research

Betaine Alleviates High-Fat Diet Induced Excessive Lipid Deposition in Gibel Carp Hepatopancreas and L8824 Cells by Enhancing VLDL Secretion through HNF4α/MTTP Pathway

Contact Info

Product

Resources

About