Gut immunity in European sea bass (Dicentrarchus labrax): a review

Picchietti, Simona; Miccoli, Andrea; Fausto, Anna Maria

doi:10.1016/j.fsi.2020.12.001

Cited by 25 publications

(16 citation statements)

References 250 publications

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“…Some orally delivered experimental vaccines were described. Their rationale is based on the key immunological role held by mucosal tissues, a fascinating subject that has received increasing interest from the academic [110][111][112][113][114][115][116] and industry sectors. Regarding the latter, worthy of note is a ground-breaking project that was recently funded by the Scottish Aquaculture Innovation Centre, the aim of which is to develop an efficient sea lice control strategy through nanoparticle technologies, also exploiting innovative feedadministered vaccines (https://www.scottishaquaculture.com/projects/health-andwelfare/details/development-of-an-orally-administered-novel-sea-lice-vaccine-targetingmucosal-immunity/).…”

Section: Discussionmentioning

confidence: 99%

State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species

et al. 2021

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In the last three decades, the aquaculture sector has experienced a 527% growth, producing 82 million tons for a first sale value estimated at 250 billion USD. Infectious diseases caused by bacteria, viruses, or parasites are the major causes of mortality and economic losses in commercial aquaculture. Some pathologies, especially those of bacterial origin, can be treated with commercially available drugs, while others are poorly managed. In fact, despite having been recognized as a useful preventive measure, no effective vaccination against many economically relevant diseases exist yet, such as for viral and parasitic infections. The objective of the present review is to provide the reader with an updated perspective on the most significant and innovative vaccine research on three key aquaculture commodities. European sea bass (Dicentrarchus labrax), Nile tilapia (Oreochromis niloticus), and Atlantic salmon (Salmo salar) were chosen because of their economic relevance, geographical distinctiveness, and representativeness of different culture systems. Scientific papers about vaccines against bacterial, viral, and parasitic diseases will be objectively presented; their results critically discussed and compared; and suggestions for future directions given.

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Section: Discussionmentioning

confidence: 99%

State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species

et al. 2021

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“…The gastrointestinal tract is a hollow muscular tube that connects a series of alimentary organs, starting at the buccal cavity to the rectum ( 9 ). It is a multifunctional system that is not restricted only to digestion, but also nutrient absorption and sensing, water and electrolyte balance, hormone secretion, and the more challenging task to establish immunity ( 10 ).…”

Section: Gut Immunitymentioning

confidence: 99%

“…In this segment, the absorption of dietary protein takes place by enterocytes or intestinal absorptive cells ( 13 ). As the longest portion of the gut ( 9 ) and the site for the majority of digestive activities ( 15 ), the second segment or the midgut possesses enzymes from the pancreas, liver and intestinal wall to catalyze digestion and uptake of macromolecules ( 16 ). The midgut harbors highly diverse microbial consortia that are believed to take part in the digestion ( 17 ).…”

Section: Gut Immunitymentioning

confidence: 99%

“…It should be noted that there are studies that have categorized the entire gut into two segments instead of three (fore, mid and hind); therefore, the third gut segment was neglected or not recognized in these studies ( 9 , 12 ). Some studies conducted with Atlantic salmon ( Salmo salar ) had divided the intestine into the mid and posterior regions, where the mid-intestine region was further subdivided into two, termed the first and second segments of the midgut ( 18 , 20 , 27 ).…”

Section: Gut Immunitymentioning

confidence: 99%

“…As one of the major parts of mucosal lymphoid tissues that are constantly connected with external environment and could be primary entry sites of pathogenic intrusions, fish gut-associated lymphoid tissues (GALTs) play an indispensable role in fish health ( 29 ). Unlike mammalian GALTs that possess organized structures such as mesenteric lymph nodes and Peyer’s patches ( 9 ), teleosts have diffusely organized GALTs that accommodate abundant myeloid and lymphoid cells, which regulate homeostasis to protect the host from potentially pathogenic microbes and to tolerate anodyne food-derived antigens and commensal microbiota ( 9 , 30 ).…”

Section: Gut Immunitymentioning

confidence: 99%

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Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture

et al. 2021

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The gastrointestinal immune system plays an important role in immune homeostasis regulation. It regulates the symbiotic host-microbiome interactions by training and developing the host’s innate and adaptive immunity. This interaction plays a vital role in host defence mechanisms and at the same time, balancing the endogenous perturbations of the host immune homeostasis. The fish gastrointestinal immune system is armed with intricate diffused gut-associated lymphoid tissues (GALTs) that establish tolerance toward the enormous commensal gut microbiome while preserving immune responses against the intrusion of enteric pathogens. A comprehensive understanding of the intestinal immune system is a prerequisite for developing an oral vaccine and immunostimulants in aquaculture, particularly in cultured fish species. In this review, we outline the remarkable features of gut immunity and the essential components of gut-associated lymphoid tissue. The mechanistic principles underlying the antigen absorption and uptake through the intestinal epithelial, and the subsequent immune activation through a series of molecular events are reviewed. The emphasis is on the significance of gut immunity in oral administration of immunoprophylactics, and the different potential adjuvants that circumvent intestinal immune tolerance. Comprehension of the intestinal immune system is pivotal for developing effective fish vaccines that can be delivered orally, which is less labour-intensive and could improve fish health and facilitate disease management in the aquaculture industry.

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Immunohistochemical characterisation of the adult Nothobranchius furzeri intestine

Borgonovo,

Allende-Castro,

Medinas

et al. 2023

Cell Tissue Res

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Gut immunity in European sea bass (Dicentrarchus labrax): a review

Cited by 25 publications

References 250 publications

State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species

State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species

Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture

Immunohistochemical characterisation of the adult Nothobranchius furzeri intestine

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