Gut <i>Bacteroides</i> species in health and disease

Zafar, Hassan; Saier, Milton H.

doi:10.1080/19490976.2020.1848158

Cited by 468 publications

(325 citation statements)

References 179 publications

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“…In a gut environment rich in iron as in our iron-supplemented experiments, B. vulgatus is likely to benefit with enhanced virulence. This bacterium is one of the most abundant in the gut [ 55 ] and has been associated with inflammation [ 50 , 56 ] via the activation of inflammatory pathways [ 55 ]. An increased abundance of B. vulgatus in an iron-rich environment is therefore believed to sustain a pro-inflammatory environment, which may in turn alter the gut barrier function and impact the overall health of the host.…”

Section: Discussionmentioning

confidence: 99%

Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota

et al. 2021

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Background Oral iron supplementation is commonly prescribed for anemia and may play an important role in the gut microbiota recovery of anemic individuals who received antibiotic treatment. This study aims to investigate the effects of iron supplementation on gut microbiota recovery after antibiotics exposure. Results Mice were subjected to oral antibiotic treatment with neomycin and metronidazole and were fed diets with different concentrations of iron. The composition of the gut microbiota was followed throughout treatment by 16S rRNA sequencing of DNA extracted from fecal samples. Gut microbiota functions were inferred using PICRUSt2, and short-chain fatty acid concentration in fecal samples was assessed by liquid-chromatography mass spectrometry. Iron supplementation after antibiotic exposure shifted the gut microbiota composition towards a Bacteroidetes phylum-dominant composition. At the genus level, the iron-supplemented diet induced an increase in the abundance of Parasutterella and Bacteroides, and a decrease of Bilophila and Akkermansia. Parasutterella excrementihominis, Bacteroides vulgatus, and Alistipes finegoldii, were more abundant with the iron excess diet. Iron-induced shifts in microbiota composition were accompanied by functional modifications, including an enhancement of the biosynthesis of primary bile acids, nitrogen metabolism, cyanoamino acid metabolism and pentose phosphate pathways. Recovery after antibiotic treatment increased propionate levels independent of luminal iron levels, whereas butyrate levels were diminished by excess iron. Conclusions Oral iron supplementation after antibiotic therapy in mice may lead to deleterious changes in the recovery of the gut microbiota. Our results have implications on the use of oral iron supplementation after antibiotic exposure and justify further studies on alternative treatments for anemia in these settings.

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Section: Discussionmentioning

confidence: 99%

Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota

et al. 2021

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“…Bacteroides have been associated with improving gut health, especially with reduced constipation, and protective of other diseases such as autism spectrum disorder [67]. Several species of Bacteroides are considered dominant beneficial bacteria because they metabolize polysaccharides and oligosaccharides and provide nutrition and vitamins to the host and other intestinal microbial residents [68]. We also detected Bifidobacterial dominance-a taxa that helps modulate gut microbiota and prevent inflammation [69], especially among those who rarely consume dairy or who do not consume soy.…”

Section: Discussionmentioning

confidence: 75%

Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women

Lacourt-Ventura

Vilanova-Cuevas

Rivera-Rodríguez

et al. 2021

IJERPH

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The U.S. Hispanic female population has one of the highest breast cancer (BC) incidence and mortality rates, while BC is the leading cause of cancer death in Puerto Rican women. Certain foods may predispose to carcinogenesis. Our previous studies indicate that consuming combined soy isoflavones (genistein, daidzein, and glycitein) promotes tumor metastasis possibly through increased protein synthesis activated by equol, a secondary dietary metabolite. Equol is a bacterial metabolite produced in about 20–60% of the population that harbor and exhibit specific gut microbiota capable of producing it from daidzein. The aim of the current study was to investigate the prevalence of equol production in Puerto Rican women and identify the equol producing microbiota in this understudied population. Herein, we conducted a cross-sectional characterization of equol production in a clinically based sample of eighty healthy 25–50 year old Puerto Rican women. Urine samples were collected and evaluated by GCMS for the presence of soy isoflavones and metabolites to determine the ratio of equol producers to equol non-producers. Furthermore, fecal samples were collected for gut microbiota characterization on a subset of women using next generation sequencing (NGS). We report that 25% of the participants were classified as equol producers. Importantly, the gut microbiota from equol non-producers demonstrated a higher diversity. Our results suggest that healthy women with soy and high dairy consumption with subsequent equol production may result in gut dysbiosis by having reduced quantities (diversity) of healthy bacterial biomarkers, which might be associated to increased diseased outcomes (e.g., cancer, and other diseases).

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“…Search terms related to diet (e.g., "Diet," "Nutrition," "Fiber"), microbiome (e.g., Figure 1. Venn diagram grouping various bacteria genus (bold) and species as anti-inflammatory (left circle), pro-inflammatory (right circle), or both (overlap between circles) depending on their abundance and environment [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Included microbiota were selected based on the frequency of appearance in the included articles of this systematic review to allow for comparisons between articles.…”

Section: Search Strategymentioning

confidence: 99%

“…While a richer and more diverse microbiome is characterized as healthy, the optimal composition of a healthy gut microbiome is still unclear and seems to vary per individual [ 16 , 17 ]. Summarized in Figure 1 are specific bacteria genera and species usually associated with health, in part due to their anti-inflammatory effects, and on the contrary, those known as opportunistic pathogens able to induce pro-inflammatory responses [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. An overlapping characteristic of the anti-inflammatory beneficial bacteria is their ability to produce short-chain fatty acids (SCFA), specifically butyrate, acetate, and propionate [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, Proteobacteria, such as E. coli and Shigella , and Collinsella are associated with chronic inflammatory diseases [ 27 , 28 ]. For certain bacteria, shown in the overlapping area of the Venn diagram of Figure 1 , whether their functions are beneficial or harmful to the host depends on factors such as their abundance and their environment [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Dietary Interventions on Chronic Inflammatory Diseases in Relation to the Microbiome: A Systematic Review

et al. 2021

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Chronic inflammation plays a central role in the pathophysiology of various non-communicable diseases. Dietary interventions can reduce inflammation, in part due to their effect on the gut microbiome. This systematic review aims to determine the effect of dietary interventions, specifically fiber intake, on chronic inflammatory diseases and the microbiome. It aims to form hypotheses on the potential mediating effects of the microbiome on disease outcomes after dietary changes. Included were clinical trials which performed a dietary intervention with a whole diet change or fiber supplement (>5 g/day) and investigated the gut microbiome in patients diagnosed with chronic inflammatory diseases such as cardiovascular disease (CVD), type 2 diabetes (T2DM), and autoimmune diseases (e.g., rheumatoid arthritis (RA), inflammatory bowel disease (IBD)). The 30 articles which met the inclusion criteria had an overall moderate to high risk of bias and were too heterogeneous to perform a meta-analysis. Dietary interventions were stratified based on fiber intake: low fiber, high fiber, and supplemental fiber. Overall, but most pronounced in patients with T2DM, high-fiber plant-based dietary interventions were consistently more effective at reducing disease-specific outcomes and pathogenic bacteria, as well as increasing microbiome alpha diversity and short-chain fatty acid (SCFA)-producing bacteria, compared to other diets and fiber supplements.

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Gut Bacteroides species in health and disease

Cited by 468 publications

References 179 publications

Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota

Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota

Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women

The Effect of Dietary Interventions on Chronic Inflammatory Diseases in Relation to the Microbiome: A Systematic Review

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