Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters

Patriti, Alberto; Facchiano, Enrico; Gullà, N; Aisa, Maria Cristina; Annetti, Claudia

doi:10.1097/01.sla.0000250941.44516.b3

Cited by 17 publications

(6 citation statements)

References 8 publications

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“…Consistent with our findings, other studies in humans and rodent models have shown that following SG, IT and SGIT surgeries, postprandial GLP-1 and PYY concentrations are increased (36,46,77,119,132,133). Previous studies have also demonstrated that central and/or peripheral administration of GLP-1 decreases food intake, body weight (134,135) and produces anti-diabetic effects (77).…”

Section: Markers Of Glucose Metabolism In Adipose Tissuesupporting

confidence: 80%

“…Numerous studies have reported that enhanced GLP-1 secretion following SG, IT and SGIT surgeries is associated with improvement in blood glucose homeostasis (46,119,132,137). However, but there is only one study that find that both duodenal-jejunal Garvey et al demonstrated that cellular insulin resistance in adipocytes from subjects who are obese and diabetic is accompanied by 40-80% depletion of GLUT-4 (141).…”

Section: Markers Of Glucose Metabolism In Adipose Tissuementioning

confidence: 99%

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Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats

Nausheen

Shah

Pezeshki

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Gastric bypass surgeries for obesity are hypothesized to produce weight loss and improve diabetes by multiple mechanisms including gastric restriction and lower gut stimulation.The surgeries typically involve rearrangement of the fore-gut, hind-gut or both. We compared the effects of foregut (Sleeve Gastrectomy, SG), hindgut (Ileal Transposition; IT), both (SG+IT), or sham manipulations, on food intake, body weight and glucose tolerance in male SD rats. SG, IT and SGIT surgeries produced transient reduction in food intake and weight gain but improvements in glucose tolerance. SG, IT and SGIT surgeries increased plasma GLP-1 concentrations; IT and SGIT increased PYY concentrations. The protein abundance of key markers of glucose metabolism (e.g. GLUT4, AMPK, PKA, IRS-1) in muscle and adipose tissue were increased following SG, IT, or SGIT. Improvement in glycemic control following these surgeries appears to be independent of changes in weight and is likely due to enhanced lower gut stimulation.iii Acknowledgment

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Section: Markers Of Glucose Metabolism In Adipose Tissuesupporting

confidence: 80%

Section: Markers Of Glucose Metabolism In Adipose Tissuementioning

confidence: 99%

Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats

Nausheen

Shah

Pezeshki

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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“…OAGB achieved highest weight loss followed by SGLB. These results were in agreement with Le Roux et al, (2006) who found that after one-year follow-up period, BMI of patients underwent OAGB decreases from 49.8 to 36.8 [10] . Also, these results were in accordance with Ansar et al, (2020) who concluded that OAGB provides considerable weight loss for most patients.…”

Section: Discussionsupporting

confidence: 93%

The Impact of Bariatric Procedures on Local Gastrointestinal Hormones

Elsageer

Mahran

Mohamed

et al. 2022

Minia Journal of Medical Research

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Background: Many of the beneficial metabolic effects of bariatric surgery have been attributed to altered peptide hormone profiles, especially involving pancreatic and gut peptides. We aimed to assess the impact of sleeve gastrectomy (SG), one anastomosis gastric bypass (OAGB), and sleeve gastrectomy with loop bipartition (SGLB) on gastrointestinal tract hormones. Methods: A case series analysis was carried out at our institution from February 2018 to February 2021. This study included 3 groups subjected to different operations; each group consisted of 50 patients. Results: This study included 132 women (88%) and 18 men (12%). Mean age in SG, OAGB and SGLB were 33.5 SD3.89, 30.9 SD7.2, and 40.3 SD6.89 respectively. The percentage of change in Peptide YY levels two weeks postoperatively in SG, OAGB, and SGLB were 29.1%, 40.1%, and 65.6% respectively. In Glucagonlike peptide-1 were 19.3%, 34.1% and 32.8% respectively. However, the percent of change in Ghrelin level two weeks were 36.5%, 50%, and 50.6% respectively. Finally, the percent change in secretin hormone levels were 61.5%, 56.9%, and 46.3% respectively. Conclusions: Differences in gastrointestinal hormones that regulate energy and glucose homeostasis are a possible mechanism for more significant weight loss after SGLB and OAGB compared to SG.

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“…However, the immediacy of T2DM resolution after RYGB suggests insulin sensitivity improves by a process independent of weight loss (41). Numerous studies have documented post-RYGB hormonal changes (11,12,28,30). However, results often conflict and no clear pattern has emerged, so beneficial outcomes of surgery are generally not attributed solely to the hormonal changes (6).…”

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confidence: 99%

Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport

Stearns

Balakrishnan

Tavakkolizadeh

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Stearns AT, Balakrishnan A, Tavakkolizadeh A. Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport. Am J Physiol Gastrointest Liver Physiol 297: G950-G957, 2009. First published September 3, 2009 doi:10.1152/ajpgi.00253.2009.-Roux-en-Y gastric bypass (RYGB) has become the gold-standard bariatric procedure, partly because of the rapid resolution of accompanying diabetes. There is increasing evidence this is mediated by duodenal exclusion. We hypothesize that duodenal exclusion suppresses intestinal Na ϩ /glucose cotransporter SGLT1-mediated glucose transport, improving glucose handling, and aimed to test this in a rodent RYGB model. Sprague-Dawley rats underwent sham procedure or duodenal exclusion by RYGB (10 cm Roux, 16 cm biliopancreatic limbs). Animals were maintained for 3 wk on a Western diet, before harvest at 10 AM, 4 PM, and 10 PM. Sections were taken from each limb for hematoxylin and eosin staining, and morphological assessment was performed. Functional glucose uptake studies, along with Western blotting and quantitative PCR, were performed on Roux limb. Histology showed morphometric changes in Roux and common limbs, with increase in villus height and crypt depth compared with BP and sham jejunum. Despite this, glucose transport was reduced by up to 68% (P Ͻ 0.001) in the Roux limb compared with sham jejunum. Normal diurnal rhythms in glucose uptake were ablated. This occurred at a posttranscriptional level, with little change in message but appearance of different weight species of Sglt1 on Western blotting. We have shown duodenal exclusion significantly influences both intestinal structure and glucose transport function, with glucose absorptive capacity reduced after RYGB. This provides a novel mechanistic explanation for some of the antidiabetic effects of RYGB. bariatric surgery; diabetes; sglt1 OBESITY, TOGETHER WITH ASSOCIATED Type 2 diabetes mellitus (T2DM), has become a surgical disease (29). Bariatric surgery now represents the first-line treatment for morbid obesity, leading to resolution of obesity-related comorbidities such hypertension, sleep apnea, and T2DM and consequently improved life expectancy (1, 9, 35).Roux-en-Y gastric bypass (RYGB) is regarded as the goldstandard therapy for weight loss, with 60 -70% excess weight loss at two years (7). An important observation is the rapid associated resolution of T2DM, achieved prior to any significant weight loss; 84% of all patients had complete remission of T2DM, often within days after surgery (7). These impressive results have led many to regard RYGB as a metabolic operation. Unfortunately, 70% of T2DM patients do not fulfill the weight criteria to be eligible for bariatric surgery. Although there has been debate about the role of this procedure in T2DM in less obese patients, the invasive nature of the procedure has prevented widespread acceptance (10,23,34).Unfortunately, the mechanisms underlying diabetes resolution in RYGB remain unclear, limiting development of less invasive alternatives. A major feature of T...

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Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters

Cited by 17 publications

References 8 publications

Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats

Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats

The Impact of Bariatric Procedures on Local Gastrointestinal Hormones

Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport

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