Gut health benefits of licorice and its flavonoids as dietary supplements

Bethapudi, Bharathi; Murugan, Sasikumar; Nithyanantham, Muruganantham; Singh, Vineet; Agarwal, Amit; Mundkinajeddu, Deepak

doi:10.1016/b978-0-12-821232-5.00008-2

Cited by 5 publications

(4 citation statements)

References 95 publications

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“…Liquiritin, glabridin, isoliquiritigenin, liquiritigenin, isoliquiritin, rhamnoliquirilin, shinpterocarpin, licochalcone A, glucoliquiritin apioside, prenyllicoflavone A, shinflavanone, dehydroglyasperin C, licoflavone A, 1-metho-xyphaseolin, and licuraside are some of the active ingredients of licorice flavonoids. In addition, licorice flavonoids have several medicinal benefits such as antiulcer, antitumor, antimicrobial, anti-inflammatory, antiviral, antioxidant, hepatoprotective, antidepressive, and hypoglycemic action [15].…”

Section: Flavonoidsmentioning

confidence: 99%

Pharmacological Mechanisms and Adjuvant Properties of Licorice Glycyrrhiza in Treating Gastric Cancer

Tibenda,

Du,

Huang

et al. 2023

Molecules

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Licorice is a remarkable traditional Chinese medicine obtained from the dried root and rhizomes of the Glycyrrhiza genus, and t has been utilized in China for many centuries. It consists of more than 300 compounds that are mainly divided into triterpene saponins, flavonoids, polysaccharides, and phenolic components. The active compounds of licorice have been found to possess multiple biological activities, including antitumor, anti-inflammatory, antiviral, antimicrobial, immunoregulatory, cardioprotective, and neuroprotective functions. In addition to providing a brief overview of licorice’s adjuvant properties, this review describes and analyzes the pharmacological mechanisms by which licorice components function to treat gastric cancer. Furthermore, licorice compounds are also found to be potent adjuvant chemotherapy agents, as they can improve the quality of life of cancer patients and alleviate chemotherapy-induced adverse effects.

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Section: Flavonoidsmentioning

confidence: 99%

Pharmacological Mechanisms and Adjuvant Properties of Licorice Glycyrrhiza in Treating Gastric Cancer

Tibenda,

Du,

Huang

et al. 2023

Molecules

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“…In traditional Chinese medicine, "nine out of ten formulae contain licorice"; it is considered one of the essential herbal medications [7]. Licorice root has traditionally been used in herbal medicine to treat gastrointestinal problems [8], such as gastritis and peptic ulcers [9]. It is still commonly recommended for respiratory infections, coughs, bronchitis [10], and arthritis.…”

Section: Introductionmentioning

confidence: 99%

The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications

AlDehlawi,

Jazzar

2023

Healthcare

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Licorice (Radix glycyrrhizae) is a plant root extract widely used in various applications, including cosmetics, food supplements, and traditional medicine. It has a long history of medicinal use in different cultures due to its diverse pharmacological properties. Licorice has traditionally been used for treating gastrointestinal problems, respiratory infections, cough, bronchitis, arthritis, and skin conditions. In recent years, the potential therapeutic benefits of licorice for oral health have gained significant interest. This paper aims to provide a comprehensive review of the effects of licorice extracts and their bioactive components on common oral diseases such as dental caries, periodontitis, halitosis, candidiasis, and recurrent aphthous ulcers. The chemical composition of licorice has shown the presence of several bioactive compounds such as glycyrrhizin, glabridin, isoliquiritigenin (ISL), and licochalcone exhibiting various pharmacological activities, including anti-inflammatory, antimicrobial, antioxidative, and immunomodulatory effects. Interestingly, in certain patients, licorice has shown a promising potential to inhibit the spread of viruses, prevent biofilm formation, reduce inflammation, boost immune responses, alleviate pain, and exert antioxidative effects. In this review, we provide a brief overview of the current understanding of licorice’s therapeutic benefits in the treatment of oral ailments, emphasising its potential as an alternative treatment option for oral diseases. Further research is warranted to explore its efficacy, safety, and clinical applications using placebo-controlled clinical trials.

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“…Licorice (Glycyrrhizauralensis) is another important medicinal plant, and the roots, stolons and rhizomes of this plant have also been used in traditional medicine. The major phenolic compounds of licorice include glycosides of liquiritigenin (4,7-dihydroxyflavanone) and isoliquiritigenin (2,4,4-trihydroxychalcone) (Bethapudi et al, 2022). Licorice extract has been investigated as a substitute to bismuth that is normally used in quadruple therapy (Li et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Partially Purified Compounds from Pomegranate Peel and Licorice Extracts on Growth and Urease Activity of Helicobacter pylori

2023

JJBS

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Helicobacter pylori (H. pylori) is the main causative agent responsible for chronic gastritis, peptic ulcer, and gastric cancer in humans. An important virulence factor of H. pylori is urease that converts urea into ammonia, producing a neutral microenvironment, which allows colonization and survival in the stomach lining. Although various therapies have been introduced for the treatment of H. pylori infection, the eradication failure rate stays as high as 5-20% along with frequent recurrence of gastric ulcers even after complete healing. Looking for an alternative mode of treatment using natural products, we investigated the effects of pomegranate peel and licorice extracts that had been fractioned using ethyl acetate and methanol into 4 fractions (F1-F4) on the growth (disc diffusion and minimum inhibitory concentration -MIC) and urease activity of this pathogen. We found that all fractions had antimicrobial activity with the maximum activity observed with the F1 fraction of both pomegranate peel and licorice extracts with growth inhibitory zones of 33 mm and 26 mm, and MICs of 2 and 1 mg/ml, respectively. The F2 and F4 fractions of licorice extract, and F3 of pomegranate peel extract showed MIC values of 4 mg/mL, whereas the F4 fraction of pomegranate peel extract and F3 of licorice extract showed MIC values of 8 mg/ml. The F1 and F2 fractions of pomegranate peel caused 80 and 91% inhibition of urease activity and the F1 fraction of licorice caused total inhibition (100%) of H. pylori urease activity at MIC values. In conclusion, these results indicate that both pomegranate and licorice contain important bioactive compounds against H. pylori and should be examined further to help in the fight against this important pathogen.

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Gut health benefits of licorice and its flavonoids as dietary supplements

Cited by 5 publications

References 95 publications

Pharmacological Mechanisms and Adjuvant Properties of Licorice Glycyrrhiza in Treating Gastric Cancer

Pharmacological Mechanisms and Adjuvant Properties of Licorice Glycyrrhiza in Treating Gastric Cancer

The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications

Inhibitory Effect of Partially Purified Compounds from Pomegranate Peel and Licorice Extracts on Growth and Urease Activity of Helicobacter pylori

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