Gut feelings 1. Mind, mood and gut in irritable bowel syndrome: approaches to psychiatric care

Keightley, Philip; Pavli, Paul; Platten, Jan; Looi, Jeffrey Cl

doi:10.1177/1039856215590033

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…The bidirectional microbiota-gut-brain axis (MGB) connects the gut microbiota with the human brain, and this synergy in turn influences human behaviors [9,10]. The MGB axis [11] includes the central nervous system, the enteric nervous system, the autonomic nervous system, the neuro-endocrine (e.g., serotonin) and neuro-immune pathways (e.g., pro-inflammatory cytokines), and the gut microbiome [11,12].…”

Section: Introductionmentioning

confidence: 99%

Association between Gut Microbiota and Infant’s Temperament in the First Year of Life in a Chinese Birth Cohort

Wang

Chen

et al. 2020

Microorganisms

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Infant temperament characteristics play a critical role in children’s developmental pathways and can predict adulthood psychopathology. The diversity and composition of the gut microbiota are associated with human temperament in both adults and young children. However, the relationship between the gut microbiota and temperament in 12-month-old infants is rarely studied; this developmental period is when temperament reaches a relatively stable stage. We used high-throughput sequencing methods to explore whether temperament characteristics were associated with gut microbiota diversity and composition. Infants’ fecal samples were collected at 12 months of age for the gut microbiota analysis. Based on the primary caregivers’ reports, infants’ temperaments were measured using the Infant Behavior Questionnaire-revised (IBQ-R). This study included 51 infants, including 20 boys and 31 girls, with a mean age of 12.25 months. Results showed that soothability was positively correlated with maternal education level (β = 0.29, p = 0.043, adjust p = 0.025) and the abundance of Bifidobacterium genera (β = 0.62, p = 0.004, adjust p = 0.002). Conversely, cuddliness was negatively correlated with the abundance of Hungatella genera. There was no significant difference in temperament based on gender. This study demonstrated that gut microbiota composition was associated with temperament in 12-month-old infants. These results point to the importance of gut microbiota balance. Future studies on the mechanisms behind the gut microbiota affecting temperament are warranted.

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Section: Introductionmentioning

confidence: 99%

Association between Gut Microbiota and Infant’s Temperament in the First Year of Life in a Chinese Birth Cohort

Wang

Chen

et al. 2020

Microorganisms

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“…Finally, Keightly 17, 18 pens two nice pieces entitled ‘gut feelings’, addressing psychological and psychiatric aspects of irritable bowel syndrome and inflammatory bowel disease. This reminds us of the complex and profound interactions between mind and body and fits well with the general theme of this issue of Australasian Psychiatry .…”

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confidence: 99%

Should we be worrying about the status of anxiety research in Australia and New Zealand?

Castle

2015

Australas Psychiatry

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Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

et al. 2016

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2´-fucosyllactose (2´-FL) is an abundant human milk oligosaccharide (HMO) in human milk with diverse biological effects. We recently reported ingested 2´-FL stimulates central nervous system (CNS) function, such as hippocampal long term potentiation (LTP) and learning and memory in rats. Conceivably the effect of 2´-FL on CNS function may be via the gut-brain axis (GBA), specifically the vagus nerve, and L-fucose (Fuc) may play a role. This study had two aims: (1) determine if the effect of ingested 2´-FL on the modulation of CNS function is dependent on the integrity of the molecule; and (2) confirm if oral 2´-FL modified hippocampal LTP and associative learning related skills in rats submitted to bilateral subdiaphragmatic vagotomy. Results showed that 2´-FL but not Fuc enhanced LTP, and vagotomy inhibited the effects of oral 2´-FL on LTP and associative learning related paradigms. Taken together, the data show that dietary 2´-FL but not its Fuc moiety affects cognitive domains and improves learning and memory in rats. This effect is dependent on vagus nerve integrity, suggesting GBA plays a role in 2´-FL-mediated cognitive benefits.

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Gut feelings 1. Mind, mood and gut in irritable bowel syndrome: approaches to psychiatric care

Cited by 4 publications

References 22 publications

Association between Gut Microbiota and Infant’s Temperament in the First Year of Life in a Chinese Birth Cohort

Association between Gut Microbiota and Infant’s Temperament in the First Year of Life in a Chinese Birth Cohort

Should we be worrying about the status of anxiety research in Australia and New Zealand?

Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

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