Gut Dysbacteriosis Is Associated with an Imbalanced Cytokines Network in Women with Unexplained Miscarriage

Liu, Yongjie; Chen, Hainan; Chen, Dan; Feng, Liping; Zhang, Jun

doi:10.21203/rs.3.rs-20415/v1

Cited by 2 publications

(2 citation statements)

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“…In this study, it was not detected in brain of the GF fetuses and its levels were also considerably lower in the other organs compared to SPF mice. Methylimidazoleacetic acid may be associated with miscarriage, potentially by the dysregulation of cytokine networks caused by imbalance in gut bacteria [48]. Another main metabolic pathway of histamine leads to the formation of imidazoleacetic acid.…”

Section: Amino Acids and Related Metabolitesmentioning

confidence: 99%

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

et al. 2022

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Background The maternal microbiota affects the development of the offspring by microbial metabolites translocating to the fetus. To reveal the spectrum of these molecular mediators of the earliest host-microbe interactions, we compared placenta, fetal intestine and brain from germ-free (GF) and specific pathogen free (SPF) mouse dams by non-targeted metabolic profiling. Results One hundred one annotated metabolites and altogether 3680 molecular features were present in significantly different amounts in the placenta and/or fetal organs of GF and SPF mice. More than half of these were more abundant in the SPF organs, suggesting their microbial origin or a metabolic response of the host to the presence of microbes. The clearest separation was observed in the placenta, but most of the molecular features showed significantly different levels also in the fetal intestine and/or brain. Metabolites that were detected in lower amounts in the GF fetal organs included 5-aminovaleric acid betaine, trimethylamine N-oxide, catechol-O-sulphate, hippuric and pipecolic acid. Derivatives of the amino acid tryptophan, such as kynurenine, 3-indolepropionic acid and hydroxyindoleacetic acid, were also less abundant in the absence of microbiota. Ninety-nine molecular features were detected only in the SPF mice. We also observed several molecular features which were more abundant in the GF mice, possibly representing precursors of microbial metabolites or indicators of a metabolic response to the absence of microbiota. Conclusions The maternal microbiota has a profound impact on the fetal metabolome. Our observations suggest the existence of a multitude of yet unidentified microbially modified metabolites which pass through the placenta into the fetus and potentially influence fetal development.

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Section: Amino Acids and Related Metabolitesmentioning

confidence: 99%

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

et al. 2022

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“…In this study, it was not detected in brain of the GF fetuses and its levels were also considerably lower in the other organs compared to SPF mice. Methylimidazoleacetic acid may be associated with miscarriage, potentially by the dysregulation of cytokine networks caused by imbalance in gut bacteria (Liu et al, 2020). Another main metabolic pathway of histamine leads to the formation of imidazoleacetic acid.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic signature of the maternal microbiota in the fetus

Pessa‐Morikawa

Husso

Kärkkäinen

et al. 2020

Preprint

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The maternal microbiota affects the development of the offspring potentially by microbial metabolites translocating to the foetus through the placenta. We compared placentae, foetal intestine and brain from germ-free (GF) and specific pathogen free (SPF) mouse dams by non-targeted metabolomic profiling. 100 annotated metabolites and altogether 3680 molecular features had significantly different levels in the placental and/or foetal tissues of GF and SPF mice. More than half of the annotated and differentially expressed metabolites had decreased levels in the GF tissues, suggesting their microbial origin or a metabolic response of the host to the presence of gut microbiota. These include known or suggested microbial metabolites, such as 5-aminovaleric acid betaine, (β-)alanine betaine, trimethylamine N-oxide, catechol-O-sulfate, and hippuric acid. Several metabolites had increased levels in the GF mice. These could be precursors of microbial metabolites or indicators of a metabolic response to the absence of gut microbiota. 99 molecular features were only detected in the SPF mice, suggesting the existence of unidentified microbially modified metabolites that potentially influence fetal development. Only a few molecular features showed significantly different levels in the placental tissues but not in other tissues, indicating that the potential microbial metabolites mostly pass through the placenta into the foetus.

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Gut Dysbacteriosis Is Associated with an Imbalanced Cytokines Network in Women with Unexplained Miscarriage

Cited by 2 publications

References 50 publications

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Metabolomic signature of the maternal microbiota in the fetus

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