Gut brain regulation using psychobiotics for improved neuropsychological illness

Abstract

Psychobiotics" are a novel class of probiotics that are beneficial to the health and functional efficiency of our brain and psychology. The main hold on command in ill conditions of the brain and psychology is overtaken by these psychobiotic bacteria (a dietary supplement) via the action/determined role of bacterial neurochemicals or neuroactive substances that are released by them in the intestinal epithelium after their ingestion. Although these psychobiotics flourish in the gut of the host consuming them, the effect is widely spread to the brain due to the communication between the gut and the brain via the bidirectional gut-brain axis. The nervous system involved in this directional process includes both the enteric nervous system and the central nervous system. With time, several corroborations have proved the effectiveness of psychobiotics in terms of mental illnesses and brain disorders. In the prevailing situation of the coronavirus pandemic, psychobiotics may serve as an aid because a majority of the population worldwide is already suffering from psychological issues due to changes in lifestyle and dietary habits, and in need of an immediate solution to cope with it. Moreover, the in silico approach is also vital for the development of biological relevance to neurosubstances.

In vitro antibacterial activity of antibiotics and plant essential oils against Escherichia coli MTCC443 supported through the molecular docking and pharmacokinetics study

“…Search Tool For Interacting Chemicals (STITCH) is a widely accepted tool for mapping chemical-protein interaction (CPI) between chemical compounds and proteins. 31,32 This networking brings together data on interactions from metabolic pathways, crystal structures, binding tests, and drug-target connections. The orally active compounds should have good pharmacodynamics along with the PK study.…”

The Human Superorganism: Using Microbes for Freedom vs. Fear

“…While microbiome status can drive fear, anxiety, stress, depression, and mental health status at virtually any time of life, early life represents a critical window for the programming of later-life responses [97]. The importance of the gut-brain axis generally and between the gut microbiome and brain status specifically is so important that an entire field of study (known as psychobiotics) has emerged to guide improved human mental health via the gut microbiome [98][99][100]. In fact, Zieli ńska et al [101] argued that psychobiotics and the manipulation of microbiota should have been used during the COVID-19 pandemic to protect our mental health.…”