“Gut–brain axis”: Review of the role of the probiotics in anxiety and depressive disorders

Abstract

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Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut derived metabolites

“…Gut health has been increasingly implicated in the development of mental health conditions such as anxiety, with modulation of the gut microbiota ( via pre/probiotics or transplantation) an increasingly promising prospect. 18,54 Here we investigated SAFF supplementation in an LPS model of chronic inflammation. Utilising a cognitive behavioural test battery, 16S rRNA sequencing, 1 H NMR metabolomic and 2DE proteomics analyses we were able to explore potential interactions across the gut–brain axis.…”

Strategies for circadian rhythm disturbances and related psychiatric disorders: a new cue based on plant polysaccharides and intestinal microbiota

“…According to the principles of micro-ecology, probiotics can adjust micro-ecological imbalance, maintain micro-ecological balance, and improve the health level of the host by using normal microbial members that are beneficial and harmless to the host or their preparations that promote the formation of substances. 97 Recent studies have confirmed that some Chinese herbs or compound preparations could regulate the intestinal micro-ecological balance to some extent. Polysaccharides are important components in Chinese herbs and play an indispensable role in the process of Chinese herbs’ curative effect.…”

Effect of Diet on Depression: A Review of Nutritional Solutions

“…Probiotics are living microorganisms that colonize the gastrointestinal system, and provide health advantages to the host when consumed in sufficient numbers (Wallace & Milev, 2021;Gawlik-Kotelnicka et al, 2021). Probiotics have been studied in both animal and human research, with promising findings such as reduction of depression-and anxiety-like behavior, meaning that it can act like natural antidepressant in patients with depressed and anxiety symptoms (Gambaro et al, 2020;Wallace & Milev, 2021). Probiotics impacted mice's behavior and reduced symptoms of depression and anxiety (Reininghaus et al, 2020;Peirce & Alviña, 2019).…”