Gut Bacterial Dysbiosis and Its Clinical Implications

Archer, Ann Catherine

doi:10.1007/978-981-33-6236-9_1

Cited by 1 publication

(3 citation statements)

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“… 20 , 21 These micro-organisms outweigh the number of human cells by a ratio of 10:1. 22 Additionally, there is considerable diversity in the microbiota between body sites (e.g. oral cavity, gastrointestinal tract, skin and vagina), with each performing specific functions beneficial to the host.…”

Section: Introductionmentioning

confidence: 99%

“… 24 The total number of genes in the microbiome is approximately 200-fold that of the human genome. 22 Therefore, it is clear that symbiosis with these micro-organisms seems to be a condition for survival. 24 …”

Section: Introductionmentioning

confidence: 99%

“… 20 Any disruption in the human microbiome, also known as dysbiosis, may alter the normal function of that organ and result in disease. 22 Therefore, a logical management approach to situations that alter our microbiota would be to deliberately increase our association with specific non-pathogenic organisms to maintain microbial homeostasis.…”

Section: Introductionmentioning

confidence: 99%

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Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study

et al. 2022

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Objective This study aimed to determine the efficacy of probiotic gargles compared with placebo gargles on reducing post-tonsillectomy morbidity in adults. Method This was a triple-blind, randomised, controlled trial and feasibility study. Thirty adults underwent elective tonsillectomy and were randomly assigned to receive either probiotic or placebo gargles for 14 days after surgery. Daily pain scores and requirement of analgesia were measured for 14 days post-operatively. Secondary outcomes assessed probiotic safety and tolerability and the feasibility of the trial. Results The probiotic group experienced less pain at rest on day 2. However, the amount of oxycodone (5 mg) tablets used was greater in the probiotic group compared with placebo. There were no statistically significant differences in the frequency of adverse effects between both groups. This trial was feasible. Conclusion This pilot study suggested that probiotic gargles do not reduce post-tonsillectomy pain or bleeding, highlighting the importance of pilot and feasibility studies in clinical research.

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Section: Introductionmentioning

confidence: 99%