Gustatory thalamus lesions eliminate successive negative contrast in rats.

Reilly, Steve; Trifunovic, Radmila

doi:10.1037/0735-7044.113.6.1242

Cited by 23 publications

(37 citation statements)

References 52 publications

(78 reference statements)

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“…Consistent with prior studies with lesions centered on the TTA [30, 34], we demonstrated that the TOA is not necessary for operant responding or for the acquisition of a conditioned aversion to sucrose. Lesions centered on the more medial TTA, however, do block sucrose ACE [23, 25], while our damage centered on the more lateral TOA (which included the TTA) did not.…”

Section: Discussionsupporting

confidence: 91%

Pontine and thalamic influences on fluid rewards: III. Anticipatory contrast for sucrose and corn oil

Liang

Norgren

Grigson

2012

Physiology & Behavior

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An anticipatory contrast effect (ACE) occurs when, across daily trials, an animal comes to respond less than normally to a first stimulus when it is followed shortly by a second, more preferred solution. Classically, ACE is studied using a low (L) concentration of saccharin or sucrose, followed by access to a higher (H) concentration of sucrose. Subjects in the control condition have two bouts of access to the weaker solution presented on the same schedule. The ACE is measured by the difference in intake of the first bout low solution between subjects in the low-low (L-L) vs. the low-high (L-H) conditions. Here we used this paradigm with sham feeding rats and determined that nutritional feedback was unnecessary for the development of ACE with two concentrations of sucrose or with two concentrations of corn oil. Next we showed that ibotenic acid lesions centered in the orosensory thalamus spared ACEs for both sucrose and corn oil. In contrast, lesions of the pontine parabrachial nuclei (PBN), the second central relay for taste in the rat, disrupted ACEs for both sucrose and corn oil. Although the sensory modalities needed for the oral detection of fats remain controversial, it appears that the PBN is involved in processing the comparison of disparate concentrations of sucrose and oil reward.

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Section: Discussionsupporting

confidence: 91%

Pontine and thalamic influences on fluid rewards: III. Anticipatory contrast for sucrose and corn oil

Liang

Norgren

Grigson

2012

Physiology & Behavior

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“…Specifically, lesions of the gustatory thalamus (GT; the functional name for the parvicellular region at the medial extension of the ventral posteromedial nucleus), which have little if any influence on CTA acquisition (Flynn, Grill, Schulkin & Norgren, 1991; Mungarndee, Lundy & Norgren, 2006: Reilly, Bornovalova, Dengler & Trifunovic, 2003; Reilly & Pritchard, 1996), eliminate the CS suppression induced with either a drug of abuse (Grigson, Lyuboslavsky & Tanase, 2000; Reilly & Trifunovic, 1999a) or a sucrose US (Reilly, Bornovalova & Trifunovic, 2004; Reilly & Pritchard, 1996; Schroy, Wheeler, Davidson, Scalera, Twining & Grigson, 2005). Together with other results (e.g., Reilly & Trifunovic 1999b, 2003), the pattern of impaired and spared gustatory functions in rats with GT lesions suggests that this nucleus is critical for the operation of the comparison mechanism that allows the relative reward value of gustatory stimuli to be determined over time (e.g., Reilly, 2005a, 2005b). …”

Section: Introductionsupporting

confidence: 54%

Morphine-induced suppression of conditioned stimulus intake: Effects of stimulus type and insular cortex lesions

2009

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Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression.

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“…Lesions that include the thalamic gustatory relay have little or no effect on preference-aversion functions, CTA, or sodium appetite. These lesions do affect behavior, however, if appropriate tests are used Pritchard, 1996b, 1997;Scalera et al, 1997;Reilly and Trifunovic, 1999).…”

Section: Resultsmentioning

confidence: 97%