Gummatous Syphilis: A Reminder

Rodríguez, Samuel; Teich, Douglas L.; Weinman, Michael; Greene, Jerry M.; Keroack, Mark A.; Apstein, Michael D.

doi:10.1093/infdis/157.3.606

Cited by 5 publications

(3 citation statements)

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“…With its constellation of nonspecific symptoms, syphilis has long earned itself the nickname, the Great Imitator. 3 Tertiary syphilis is rare. However, the prevalence of syphilis in the United States has been increasing since 2001.…”

Section: Discussionmentioning

confidence: 99%

“…1 The variability of symptoms across disease progression and similarities to other diseases can lead to a broad list of differential diagnoses complicating the accurate diagnosis of syphilis. 2,3 For this reason, providers need to have a high index of suspicion for syphilitic sequelae. In this review, we show how diagnosing tertiary syphilis can be complicated by incomplete patient histories, partial treatment at outside hospitals, and the overlap of tertiary syphilis symptoms with other diseases.…”

Section: Brief Introductionmentioning

confidence: 99%

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The Continued Rise of Syphilis: A Case Report to Aid in Identification of the Great Imitator

Finney,

Soyfer,,

Schwan

et al. 2023

JETEM

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Section: Discussionmentioning

confidence: 99%

Section: Brief Introductionmentioning

confidence: 99%

The Continued Rise of Syphilis: A Case Report to Aid in Identification of the Great Imitator

Finney,

Soyfer,,

Schwan

et al. 2023

JETEM

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“…Diagnosis is to a large extent dependent on the consideration of syphilis as part of the differential diagnosis 8 , 9 . Syphilis is known for good reason as being ‘the great imitator’ 10 . It should also be kept in mind that HIV makes it more likely for syphilis to present with atypical features and an unusual pattern of disease 1 , 4 .…”

Section: Discussionmentioning

confidence: 99%

A rare case of a chronic syphilitic gumma in a man infected with human immunodeficiency virus

Masege

2014

J. Laryngol. Otol.

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Synovitis of the knee in a 42‐year‐old man. clinicopathologic conference

Gravallese

Weissman

Corson

et al. 1993

Arthritis & Rheumatism

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The patient is a 42-year-old man from the Midwest, who was referred to a rheumatologist because of pain in his right knee. He had a history of mild low back pain, and spondylolisthesis had been noted on radiographs. At the time of referral he was free of back pain. He was a recreational runner. Three years prior to referral, he had a left medial collateral ligament tear, which required surgical repair. One year prior to referral, he developed pain and swelling in his left first metatarsophalangeal (MTP) joint while running. He was given an intramuscular injection of an unknown medication, and his symptoms improved.Four months prior to referral, he noted stiffness and snapping in the right knee. Full extension of the knee was difficult. Two months prior to referral, he suffered a mild twisting injury to the right knee and noted increasing stiffness thereafter. One month prior to referral, he consulted an orthopedic surgeon, who performed radiographs of the right knee. The arthroscopy demonstrated nodular changes within the synovium and irregular articular cartilage. No meniscal or ligamentous tear was present. The synovium was biopsied and samples were sent to pathology and to microbiology for culture. A portion of the sample was placed in formalin fixative and a portion was placed in absolute alcohol for pathologic evaluation. Hematoxylin and eosin (H & Ebstained sections of synovium revealed granulomatous synovitis, with giant cells. Findings on polarizing microscopy of the alcoholfixed, H & E-stained sections were negative. Special stains for mycobacteria and fungi, as well as routine cultures and cultures for acid-fast bacilli (AFB) and fungi, gave negative results. DrThree weeks after the arthroscopy, the patient was seen in consultation by a rheumatologist. His interim history was notable for the development of mild pain and stiffness of the right forefoot, without antecedent injury. He had no pain in the left knee, low back, ankle, or heel. He denied having a malar or other rash, photosensitivity, iritis, conjunctivitis, nephrolithiasis, colitis, dysuria, fever, chills, weight loss, cough, or shortness of breath. He was taking acetaminophen plus codeine (Tylenol #3; McNeil, Fort Washington, PA), 1-2 tabletdday.

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Gummatous Syphilis: A Reminder

Cited by 5 publications

References 0 publications

The Continued Rise of Syphilis: A Case Report to Aid in Identification of the Great Imitator

The Continued Rise of Syphilis: A Case Report to Aid in Identification of the Great Imitator

A rare case of a chronic syphilitic gumma in a man infected with human immunodeficiency virus

Synovitis of the knee in a 42‐year‐old man. clinicopathologic conference

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