Gum Arabic supplementation improved antioxidant status and alters expression of oxidative stress gene in ovary of mice fed high fat diet

Ahmed, Abdelkareem A.; Fedail, Jaafar S.; Musa, Hassan Hussein; Musa, Taha Hussein; Sifaldin, Amal Z.

doi:10.1016/j.mefs.2015.10.001

Cited by 37 publications

(16 citation statements)

References 66 publications

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“…Our findings suggested that HSP regulated the activity of antioxidant enzymes via enhancing the mRNA expression level of intestinal antioxidant enzymes, thereby alleviating the intestinal damage caused by oxidative stress. The results of the study indicated that HSP as a sulfated polysaccharides could enhance expression of a variety of antioxidant enzymes to defend oxidative damage as the previous studies [ 21 , 46 , 47 ].…”

Section: Discussionsupporting

confidence: 60%

Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice

Xue

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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Hemp seed has been used as a traditional oriental medicine and health food in China for centuries. Polysaccharides from hemp seed (HSP) exhibit important properties of intestinal protection, but there are limited data on the specific underlying mechanism. The primary objective of this study was to investigate the protective effect of HSP on intestinal oxidative damage induced by cyclophosphamide (Cy) in mice. The results showed that pretreatment with HSP significantly increased the average daily gain, thymus index, spleen index, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activity in serum and ileal homogenate and significantly reduced malondialdehyde (MDA) content in ileal homogenate. In addition, the expression levels of SOD, GSH-Px, Nrf2, heme oxidase-1 (HO-1), and quinoneoxidoreductase-1 (NQO1) mRNA in ileal homogenate were significantly increased. Western blot results showed that HSP significantly upregulated the expression of Nrf2 protein and downregulated the expression of Keap1 protein in the ileum. Collectively, our findings indicated that HSP had protective effects on intestinal oxidative damage induced by Cy in mice, and its mechanism might be related to the activation of Nrf2-Keap1 signaling pathway.

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Section: Discussionsupporting

confidence: 60%

Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice

Xue

Zhou

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Some studies showed the effectiveness of gum Arabic as antioxidant material in food preservation [5,6] and in animals and humans through increasing the concentration of antioxidant enzymes and decreasing the oxidizing molecules in different organs [7,8]. With regard to the side effects of gum Arabic, some studies have reported the uncoupling of oxidative phosphorylation in the heart and liver [9], allergy and hypersensitivity [10,11].The aim of this article was to investigate the effect of gum Arabic on the liver function and antioxidant activity of Sprague-Dawley rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gum Arabic on Liver Function And Antioxidant Enzymes of Sprague-Dawley Rats

Babiker¹,

Abbas²,

Mohammed³

2017

IOSRJPBS

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“…Abdominal or central obesity is the main sign of metabolic syndrome that results in female infertility. demonstrated that administration of GA in drinking water of female mice fed with high fat diet to induce obesity, there was a reduction in lipid peroxidation and an elevation in ovarian antioxidant enzymes activity (superoxide dismutase, catalase and glutathione peroxidase) along with raised mRNA expression and reduced in ovary degenerative changes were observed which in turn may improve reproductive efficacy and manage sterility induced by obesity (47) .…”

Section: Effect On Fertilitymentioning

confidence: 96%

Clinical effects of Arabic gum (Acacia): A mini review

Jaafar¹

2019

IJPS

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Gum Arabic is a natural gummy exudate gained from the trees of Acacia species (Acacia senegal and Acacia seyal), Family: Fabaceae. Gum Arabic considers as a dietary fiber with a high percentage of carbohydrates and low protein content. Sugars arabinose and ribose were originally discovered and isolated from gum Arabic and it is representing the original source of these sugars. A gum emanation from trees occurs under stress conditions such as heat, poor soil fertility, drought, and injury. Mainly gum is produced in belt region of Africa, mainly Sudan, Chad, and Nigeria. In the food industry, it is used in confectionery; in the pharmaceutical industry, it is used as emulsifier, film coating and others. Traditionally the gum used for chronic renal failure, digestive discomfort, and others. Although gum Arabic considered as an inert substance, recent information demonstrated multiple pharmacological and medical effects, such as weight reduction, antihypertensive, antihyperlipidemic, anticoagulant, antibacterial, antidiabetic, anti-inflammatory, nephroprotective and other effects.

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Gum Arabic supplementation improved antioxidant status and alters expression of oxidative stress gene in ovary of mice fed high fat diet

Cited by 37 publications

References 66 publications

Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice

Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice

Effect of Gum Arabic on Liver Function And Antioxidant Enzymes of Sprague-Dawley Rats

Clinical effects of Arabic gum (Acacia): A mini review

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