Gum Arabic-induced oral photoprotection: Shifting the balance against circulating immune suppressive cytokines

Omer, Saida Abd Elkreem; Badi, Rehab M.; Gar-Elnabi, Mohamed E. M.; Gafar, Rana Alh.; Saeed, Amal M.

doi:10.1016/j.sciaf.2021.e00973

Cited by 2 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antioxidant property is owing to its content of amino acid residues such as lysine, tyrosine, and histidine as well as branched chains of polysaccharides [22,24]. There is copious evidence corroborating the idea that AG consumption increases the activity of antioxidant enzymes through modulation of the expression of oxidative stress genes, including Nrf2 [19,22], along with mitigation of LPO [56,57]. In addition, AG has been reported to exhibit potent anti-inflammatory effects via suppuration of TNF-α, iNOS expression, monocyte chemotactic protein-1, and IL-6 [19,23,37].…”

Section: Discussionmentioning

confidence: 98%

“…AG, is an edible proteinaceous polysaccharide plant product widely used in Arab folk medicine for its renowned antioxidant, anti-inflammatory, and immunomodulatory capabilities [56]. The antioxidant property is owing to its content of amino acid residues such as lysine, tyrosine, and histidine as well as branched chains of polysaccharides [22,24].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, AG has been reported to exhibit potent anti-inflammatory effects via suppuration of TNF-α, iNOS expression, monocyte chemotactic protein-1, and IL-6 [19,23,37]. Moreover, AG is a rich source of bioavailable short-chain fatty acids produced in substantial quantities by intestinal microbiota's fermentation of AG, mainly butyrate, that play a crucial function in suppressing the expression of proinflammatory cytokines [26,[56][57][58]. The current histopathological examination revealed a decreased inflammatory cell infiltration in liver tissues when AG was provided to AF-intoxicated animals.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Arabic Gum Could Alleviate the Aflatoxin B1-provoked Hepatic Injury in Rat: The Involvement of Oxidative Stress, Inflammatory, and Apoptotic Pathways

Ahmed

Rayes

Khalil

et al. 2022

Toxins

View full text Add to dashboard Cite

Aflatoxin B1 (AF) is an unavoidable environmental pollutant that contaminates food, feed, and grains, which seriously threatens human and animal health. Arabic gum (AG) has recently evoked much attention owing to its promising therapeutic potential. Thus, the current study was conducted to look into the possible mechanisms beyond the ameliorative activity of AG against AF-inflicted hepatic injury. Male Wistar rats were assigned into four groups: Control, AG (7.5 g/kg b.w/day, orally), AF (200 µg/kg b.w), and AG plus AF group. AF induced marked liver damage expounded by considerable changes in biochemical profile and histological architecture. The oxidative stress stimulated by AF boosted the production of plasma malondialdehyde (MDA) level along with decreases in the total antioxidant capacity (TAC) level and glutathione peroxidase (GPx) activity. Additionally, AF exposure was associated with down-regulation of the nuclear factor erythroid2–related factor2 (Nrf2) and superoxide dismutase1 (SOD1) protein expression in liver tissue. Apoptotic cascade has also been evoked following AF-exposure, as depicted in overexpression of cytochrome c (Cyto c), cleaved Caspase3 (Cl. Casp3), along with enhanced up-regulation of inflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin (IL)-6, inducible nitric oxide synthase (iNOS), and nuclear factor kappa-B transcription factor/p65 (NF-κB/p65) mRNA expression levels. Interestingly, the antioxidant and anti-inflammatory contents of AG may reverse the induced oxidative damage, inflammation, and apoptosis in AF-exposed animals.

show abstract