Gum arabic improves semen quality and oxidative stress capacity in alloxan induced diabetes rats

Fedail, Jaafar S.; Ahmed, Abdelkareem A.; Musa, Hassan Hussein; Ismail, Elsadik; Sifaldin, Amal Z.; Musa, Taha Hussein

doi:10.1016/j.apjr.2016.07.014

Cited by 33 publications

(24 citation statements)

References 61 publications

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“…28 Since the male reproductive compromise during DM can be mediated through ROS, antioxidant therapy may be useful for treating DM related infertility in males. [18][19][20][21]25,28 While our studies revealed no great differences in antioxidant enzymes activities and lipid peroxidation between days 14 and 21, data from the latter time point evaluation showed a slight improvement in antioxidant defense systems. Moreover, present results suggest that usage of Gb can be one of the more suitable choices for ameliorating oxidative stress on testis during DM.…”

Section: Discussioncontrasting

confidence: 57%

“…In the same sense, other studies reported the protective effects of ghrelin, royal jelly, gum Arabic and gallic acid on antioxidant defense system in DM male infertility. [19][20][21]25 Elevated oxidative stress accompanied by an antioxidant deficit is proposed to be a major factor leading in the pathogenesis of diabetic complications such as male reproductive disorders. 26 Indeed, hyperglycemia during diabetes causes an increased production of free radicals, especially reactive oxygen species (ROS) in all tissues.…”

Section: Discussionmentioning

confidence: 99%

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The Improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin

et al. 2019

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Background: This study evaluated the possible protective effects of Gordonia bronchialis (Gb) on oxidative stress and some subsequent alterations on testis from rats undergoing an experimentally induced type 1 diabetes. Methods: A total of 40 male rats were randomly divided into four groups of ten. Diabetes was induced by injection of 55 mg/kg streptozotocin in 30 rats. Oral administration of Gb at dose of 105 (low dose) and 107 (high dose) CFU/rat was performed in two groups continuously for 14 days. The third and fourth groups received normal saline as the diabetic and healthy control groups, respectively. The blood and testicular tissue samples were taken on the 14th and 21st days post treatment for biochemical and histopathological evaluations. Results: Significant differences were found in blood glucose level, insulin, IL-6 and TNF-α values together with catalase and superoxide dismutase activities and malondialdehyde level in the diabetic group in comparison with healthy and Gb recipient groups. Moreover, the histopathological lesions observed in the diabetic rats mainly included basement membrane thickening, decreased number of Sertoli cells, and severe reduction of spermatogenesis markedly attenuated in Gb-treated rats. Conclusion: Taken together, it seems that oral administration of Gb could ameliorate testicular damage associated with some related parameters in the diabetic animal model.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

The Improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin

et al. 2019

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“…Fedail JS et al (2016) reported that GA consumption resulted in improvement in degenerative testicular tissue of alloxan-induced diabetic rats, enhanced semen quality, and reduction in lipid peroxidation; furthermore, the activity of antioxidant enzymes together with their mRNA expression was reported to be increased; these effects might have roles in the management of reproductive dysfunction in diabetic men (48) .…”

Section: Effect On Fertilitymentioning

confidence: 99%

Clinical effects of Arabic gum (Acacia): A mini review

Jaafar¹

2019

IJPS

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Gum Arabic is a natural gummy exudate gained from the trees of Acacia species (Acacia senegal and Acacia seyal), Family: Fabaceae. Gum Arabic considers as a dietary fiber with a high percentage of carbohydrates and low protein content. Sugars arabinose and ribose were originally discovered and isolated from gum Arabic and it is representing the original source of these sugars. A gum emanation from trees occurs under stress conditions such as heat, poor soil fertility, drought, and injury. Mainly gum is produced in belt region of Africa, mainly Sudan, Chad, and Nigeria. In the food industry, it is used in confectionery; in the pharmaceutical industry, it is used as emulsifier, film coating and others. Traditionally the gum used for chronic renal failure, digestive discomfort, and others. Although gum Arabic considered as an inert substance, recent information demonstrated multiple pharmacological and medical effects, such as weight reduction, antihypertensive, antihyperlipidemic, anticoagulant, antibacterial, antidiabetic, anti-inflammatory, nephroprotective and other effects.

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“…Other studies reported several favorable renal effects including reduced plasma phosphate concentration, blood pressure, proteinuria, as well as extra renal effects such as slowing of intestinal glucose transport, which might be of value in the prevention and treatment of obesity and diabetes [17, 18]. It has been also reported to induce fetal hemoglobin in sickle cell anemia [ 19], prevents and enhances healing of gastric ulcers [20], influences the expression of murine ovarian oxidative stress gene [21] and improves semen quality and oxidative stress capacity in alloxan-induced diabetes in rats [22].…”

Section: Introductionmentioning

confidence: 99%

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

Selem

Rashed

Younis

et al. 2018

Preprint

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Abstract. CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018; 26Schistosomiasis is one of the most socioeconomically exhausting parasitic 27 infection in tropical and subtropical areas. Praziquantel (PZQ), the only common 28 schistosocidal drug in use, is not efficient enough for treatment of immature infection. 29Arabic gum (AG) is a complex polysaccharide acts as anti-oxidant which modulates the Author summary 46Schistosomiasis is a major public health threat in many parts of the world, it 47 affects more than 240 million people in more than 70 countries and almost 800 million 48 people are at risk of acquiring this disease. Serious consequences and disabilities might . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018;

show abstract

Gum arabic improves semen quality and oxidative stress capacity in alloxan induced diabetes rats

Cited by 33 publications

References 61 publications

The Improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin

The Improvement Effects of Gordonia bronchialis on Male Fertility of Rats with Diabetes Mellitus Induced by Streptozotocin

Clinical effects of Arabic gum (Acacia): A mini review

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

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