Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice

Gamal‐Eldeen, Amira M.; Moustafa, Dina; El‐Daly, Sherien M.; Abo-Zeid, Mona A.M.; Saleh, S. A.; Khoobchandani, Menka; Katti, Kavita; Shukla, Ravi

doi:10.1016/j.biopha.2017.03.006

Cited by 36 publications

(18 citation statements)

References 43 publications

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“…Species of Acacia senegal and Acacia seyal , which are indigenous to the African continent, have a high content of GA, which is used as a stabilizer in the food industry 48. Because of its highly branched structure, GA can improve the stability of nanoparticles by providing a support matrix for drug loading and delivery 40,42,48. Extensive research on AuNPs as a delivery carrier has shown effective delivery of biomolecules and drugs 4.…”

Section: Resultsmentioning

confidence: 99%

“…For example, AuNPs are used in biosensor development for signal amplification owing to their optical and electrochemical sensing capabilities 51. Moreover, AuNPs have demonstrated promise in the advancement of cancer treatment by inhibiting cell proliferation, activating a cascade of pathways to induce apoptosis,25,26,31,35,38,40,42,52 affecting mitochondrial functioning and inhibiting cell migration 53–60. Despite considerable past efforts in the diagnosis and therapy of cancer, there is still a continuing pursuit toward discovering effective modalities that limit the side effects caused by current treatments.…”

Section: Resultsmentioning

confidence: 99%

“…We have applied our pioneering research on the utility of US Food and Drug Administration (FDA)-approved GA protein to stabilize AuNPs 29,32,35,36,40,42. The synthesis of Res-GA-AuNPs was carried out in the presence of GA.…”

Section: Methodsmentioning

confidence: 99%

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Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers

Thipe

Amiri

Bloebaum

et al. 2019

IJN

Self Cite

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Background: As part of our continuing quest to enhance the efficacy of bioactive phytochemicals in cancer therapy, we report an innovative green nanotechnology approach toward the use of resveratrol for the production of biocompatible resveratrol-conjugated gold nanoparticles (Res-AuNPs). Our overarching aim is to exploit the inherent pro-apoptotic properties of gold nanoparticles (AuNPs) through synergistic anti-tumor characteristics of resveratrol, with the aim of developing a new class of green nanotechnology-based phytochemical-embedded AuNPs for applications in oncology. Method: Resveratrol was used to reduce Au 3+ to Au 0 for the synthesis of Res-AuNPs at room temperature and gum arabic (GA) was used to further encapsulate the nanoparticulate surface to increase the overall stability of the AuNPs. This comprehensive study involves the synthesis, full characterization and in vitro stability of Res-AuNPs in various biological media for their ultimate applications as anti-cancer agents against human breast (MDAMB-231), pancreatic (PANC-1) and prostate (PC-3) cancers. Results: This strategy to systematically increase the corona of resveratrol on AuNPs, in order to gain insights into the interrelationship of the phytochemical corona on the overall anti-tumor activities of Res-AuNPs, proved successful. The increased resveratrol corona on Res-AuNPs showed superior anti-cancer effects, attributed to an optimal cellular uptake after 24-hour incubation, while GA provided a protein matrix support for enhanced trans-resveratrol loading onto the surface of the AuNPs. Conclusion: The approach described in this study harnesses the benefits of nutraceuticals and nanoparticles toward the development of Res-AuNPs. We provide compelling evidence that the increased corona of resveratrol on AuNPs enhances the bioavailability of resveratrol so that therapeutically active species can be optimally available in vivo for applications in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers

Thipe

Amiri

Bloebaum

et al. 2019

IJN

Self Cite

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“…In the case of hepatocarcinogenesis during in-vivo studies with a mouse model, with or without laser irradiation, the NPs induced cancer-cell apoptosis. These results suggested the potential use of these functionalized NPs as a promising photothermal treatment [197,198]. With the intention of designing AuNPs for photothermal therapy, Silva et al [199] synthesized AuNPs using aqueous extracts of Plectranthus saccatus.…”

Section: Photodynamic and Photothermal Therapymentioning

confidence: 97%

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

et al. 2019

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The fundamental aspects of the manufacturing of gold nanoparticles (AuNPs) are discussed in this review. In particular, attention is devoted to the development of a simple and versatile method for the preparation of these nanoparticles. Eco-friendly synthetic routes, such as wet chemistry and biosynthesis with the aid of polymers, are of particular interest. Polymers can act as reducing and/or capping agents, or as soft templates leading to hybrid nanomaterials. This methodology allows control of the synthesis and stability of nanomaterials with novel properties. Thus, this review focus on a fundamental study of AuNPs properties and different techniques to characterize them, e.g., Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), UV-Visible spectroscopy, Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy, Small-angle X-Ray Scattering (SAXS), and rheology. Recently, AuNPs obtained by “green” synthesis have been applied in catalysis, in medicine, and as antibacterials, sensors, among others.

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“…Gum Arabic-AuNPs associated with laser exposure produced apoptotic, anti-inflammatory, lipid peroxidation, and anti-neovascular effects in an animal model of lung cancer 169. The apoptotic effects were mediated by elevations of cytochrome-c, death receptor 5, and caspase-3, while the anti-angiogenic activity was associated with a reduced VEGF-A expression in tumor tissue 169.…”

Section: Biomedical Applications Of Aunpsmentioning

confidence: 99%

Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

Darweesh

Ayoub

Nazzal

2019

IJN

102

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Angiogenesis is the formation of new blood vessels from pre-existing vessels. It is a highly regulated process as determined by the interplay between pro-angiogenic and anti-angiogenic factors. Under certain conditions the balance between angiogenesis stimulators and inhibitors is altered, which results in a shift from physiological to pathological angiogenesis. Therefore, the goal of therapeutic targeting of angiogenic process is to normalize vasculature in target tissues by enhancing angiogenesis in disease conditions of reduced vascularity and blood flow, such as tissue ischemia, or alternatively to inhibit excessive and abnormal angiogenesis in disorders like cancer. Gold nanoparticles (AuNPs) are special particles that are generated by nanotechnology and composed of an inorganic core containing gold which is encircled by an organic monolayer. The ability of AuNPs to alter vasculature has captured recent attention in medical literature as potential therapeutic agents for the management of pathologic angiogenesis. This review provides an overview of the effects of AuNPs on angiogenesis and the molecular mechanisms and biomedical applications associated with their effects. In addition, the main synthesis methods, physical properties, uptake mechanisms, and toxicity of AuNPs are briefly summarized.

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Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice

Cited by 36 publications

References 43 publications

<p>Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers</p>

<p>Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers</p>

Nanoengineering of Gold Nanoparticles: Green Synthesis, Characterization, and Applications

<p>Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications</p>

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