Gum arabic as a sole wall material for constructing nanoparticle to enhance the stability and bioavailability of curcumin

Ai, Chao; Zhao, Chengang; Xiang, Chunhong; Zheng, Yaguang; Zhong, Saiyi; Teng, Hui; Chen, Lei

doi:10.1016/j.fochx.2023.100724

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…The bands at 963 cm −1 are associated with -CO stretching, and the absorption at 1028 cm −1 indicates C-O-C stretching. These bands are well in line with what is described by Stephanovic et al[37] and Ai et al[38].…”

supporting

confidence: 92%

Optimization of a Microencapsulation Process Using Oil-in-Water (O/W) Emulsion to Increase Thermal Stability of Sulforaphane

Zambrano,

Bustos,

Arozarena

et al. 2023

Foods

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Sulforaphane (SFN) is a bioactive compound widely studied for its potential applications in pharmaceutical, nutraceutical, and food industries since it offers health benefits due to its nature as a Phase 2 enzyme inducer. Its application in the food industry has been limited because SFN is unstable at high temperatures in an aqueous milieu. An option to increase SFN stability and protect it from thermal degradation is microencapsulation. The aim of this work was to optimize a microencapsulation process using oil-in-water emulsion to increase the thermal stability of SFN. The operation conditions that gave the highest entrapment efficiency were determined via experimental design and response surface methodology. Thermal degradation of microencapsulated SFN was studied at 37, 50, 60, and 70 °C. The optimum microencapsulation conditions were 8 min stirring, SFN/Gum Arabic ratio of 0.82, and surfactant/oil ratio of 1.0, resulting in an entrapment efficiency of 65%, which is the highest reported so far. The thermal stability of microencapsulated SFN was greatly enhanced compared with free SFN, with a 6-fold decrease in the degradation kinetic constant and a 41% increase in the activation energy. These results will contribute to a more efficient incorporation of SFN in various food matrices and explore new microencapsulation technologies to maximize the efficiency and stability of SFN.

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supporting

confidence: 92%

Optimization of a Microencapsulation Process Using Oil-in-Water (O/W) Emulsion to Increase Thermal Stability of Sulforaphane

Zambrano,

Bustos,

Arozarena

et al. 2023

Foods

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“…These results revealed that caffeoylquinic acid-loaded MBP nanoparticles had better stability than unmodified nanoparticles at different ionic strengths, and the modified nanoparticles are more suitable for high-salt food systems. In addition, the curcumin-loaded nanoparticle using gum arabic as a sole wall material exhibited good stability under highly concentrated salinity stress ( Ai et al, 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Fabrication of caffeoylquinic acid-loaded burdock polysaccharide nanoparticles and their antioxidant activity in hydrogen peroxide-damaged HepaRG cells

Chen,

Li,

Zhu

et al. 2024

Food Chemistry: X

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“…Stability assessments of MNs under specific stress conditions, including water, cell culture medium with 10% FBS, salinity, and different pH were executed, aligning with modifications of the methods described by Ai et al 20 For this experiment, the MNs powder was dissolved in different solutions such as water, cell culture medium with 10% FBS, varied concentrations of NaCl (ranging from 0 to 0.5 M), and different pH to reach a final concentration of 2 mg/mL. The size determination served as a reference point for evaluating the stability of the MNs.…”

Section: Preparation Andmentioning

confidence: 99%

Morin-Based Nanoparticles for Regulation of Blood Glucose

Hua,

Li,

Chen

et al. 2024

ACS Appl. Mater. Interfaces

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Morin, a naturally occurring bioactive compound shows great potential as an antioxidant, anti-inflammatory agent, and regulator of blood glucose levels. However, its low water solubility, poor lipid solubility, limited bioavailability, and rapid clearance in vivo hinder its application in blood glucose regulation. To address these limitations, we report an enzymatically synthesized nanosized morin particle (MNs) encapsulated in sodium alginate microgels (M@SA). This approach significantly enhances morin's delivery efficiency and therapeutic efficacy in blood glucose regulation. Utilizing horseradish peroxidase, we synthesized MNs averaging 305.7 ± 88.7 nm in size. These MNs were then encapsulated via electrohydrodynamic microdroplet spraying to form M@SA microgels. In vivo studies revealed that M@SA microgels demonstrated prolonged intestinal retention and superior efficacy compared with unmodified morin and MNs alone. Moreover, MNs notably improved glucose uptake in HepG2 cells. Furthermore, M@SA microgels effectively regulated blood glucose, lipid profiles, and oxidative stress in diabetic mice while mitigating liver, kidney, and pancreatic damage and enhancing antiinflammatory responses. Our findings propose a promising strategy for the oral administration of natural compounds for blood glucose regulation, with implications for broader therapeutic applications.

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Gum arabic as a sole wall material for constructing nanoparticle to enhance the stability and bioavailability of curcumin

Cited by 10 publications

References 37 publications

Optimization of a Microencapsulation Process Using Oil-in-Water (O/W) Emulsion to Increase Thermal Stability of Sulforaphane

Optimization of a Microencapsulation Process Using Oil-in-Water (O/W) Emulsion to Increase Thermal Stability of Sulforaphane

Fabrication of caffeoylquinic acid-loaded burdock polysaccharide nanoparticles and their antioxidant activity in hydrogen peroxide-damaged HepaRG cells

Morin-Based Nanoparticles for Regulation of Blood Glucose

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