Guinea Pig (Cavia Porcellus) Can Be or Not Used as an Experimental Model to Study Hepatitis a Virus Infection?

Araujo, F. R.; Marchevsky, Renato Sérgio; Lima, Sheila Maria Barbosa de; Martins, Liliane Monteiro; Hooper, Cleber; Paula, Vanessa Salete de; Gaspar, Luciane P.; Freire, Marcos da Silva; Pinto, Marcelo Alves

doi:10.17525/vrrjournal.v15i1.34

VR&R

2010

DOI: 10.17525/vrrjournal.v15i1.34

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Guinea Pig (Cavia Porcellus) Can Be or Not Used as an Experimental Model to Study Hepatitis a Virus Infection?

F. R. Araujo¹,

Renato Sérgio Marchevsky²,

Sheila Maria Barbosa de Lima³

et al.

Abstract: ABSTRACTconfirmed HAV inoculation. However, anti-HAV titer alone did not guarantee immunity or predict susceptibility. We were unable to establish a guinea-pig as model of HAV.

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2020

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Applications of Animal Models in Researching Hepatitis A

Lin¹,

Min²,

Li³

et al. 2020

Hepatitis a and Other Associated Hepatobiliary Diseases

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Hepatitis diseases are remaining in the list of significant threats to human health. Human hepatitis viruses are basically classified into six major hepatotropic pathogens-hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), hepatitis E virus (HEV), and hepatitis G virus (HGV). Among these different forms of hepatotropic viruses, HAV as the leading cause of acute viral hepatitis is characterized as a kind of tiny ribonucleic acid virus that is linked to atopic disease. As we know, animal models have been instrumental in promoting understanding of complex host-virus interactions and boosting the advancement of immune therapies. So far, animal models such as nonhuman primates (NHPs) have enabled scientists to mimic and study the pathogenicities and host immune responses for hepatitis A infection. With the exception of chimpanzees and marmosets, animals like mice, pigs, guinea pigs, and tree shrews can also be selected as alternative animal models infected with HAV under laboratory conditions. In order to gain a better insight into hepatitis A pathogenesis and relevant contents, this chapter is mainly focused on the research progress in animal models of hepatitis A, and discusses the merits and demerits of these alternative models.

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Applications of Animal Models in Researching Hepatitis A

Lin¹,

Min²,

Li³

et al. 2020

Hepatitis a and Other Associated Hepatobiliary Diseases

View full text Add to dashboard Cite

show abstract

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Guinea Pig (Cavia Porcellus) Can Be or Not Used as an Experimental Model to Study Hepatitis a Virus Infection?

Abstract: ABSTRACTconfirmed HAV inoculation. However, anti-HAV titer alone did not guarantee immunity or predict susceptibility. We were unable to establish a guinea-pig as model of HAV.

Cited by 1 publication

References 29 publications

Applications of Animal Models in Researching Hepatitis A

Applications of Animal Models in Researching Hepatitis A

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