Guillain–Barre syndrome variant as a rare complication of leptospirosis

Abstract

Highlight We present a case with severe Leptospirosis who developed Acute Motor and Sensory Axonal Neuropathy (AMSAN) variant of Guillain-Barre syndrome (GBS). Our patient was successfully treated with antibiotics and total plasma Exchange. This is the first case in the literatüre that developed the AMSAN variant of GBS following Leptospirosis.

A young adult with leptospirosis associated acute inflammatory demyelinating polyneuropathy

“…He subsequently had complete neurological recovery and normalisation of his liver profile and renal functions. 8 Gamage and Fernando reported a case of a 21-year-old man who was diagnosed with leptospirosis complicated by AIDP, respiratory failure requiring ventilatory support, thrombotic thrombocytopenia purpura and optic neuritis.…”

A Rare Presentation of Leptospirosis: Dysarthria and Guillain-Barré Syndrome

“…Campylobacter jejuni infection is one of the most frequently defined causes of GBS (14). Cases with GBS have also been reported in the course of leptospirosis (1,15).…”

“…Most cases demonstrate a mild clinical course, and the disease is self-limiting. Complaints such as fever, headache, myalgia, nausea, and vomiting are the most common reasons for presentation (1)(2)(3)(4). Severe cases can have polymyositis, liver involvement, icterus and renal failure, aseptic meningitis, or peripheral neuropathy (1,2,5).…”

“…Complaints such as fever, headache, myalgia, nausea, and vomiting are the most common reasons for presentation (1)(2)(3)(4). Severe cases can have polymyositis, liver involvement, icterus and renal failure, aseptic meningitis, or peripheral neuropathy (1,2,5). Rare cases may develop intra-alveolar hemorrhage, myeloradiculopathy, cerebellar dysfunction, uveitis, or Guillain-Barré Syndrome (GBS) (5)(6)(7).…”