Guillain‐Barré syndrome in a child with pain: lessons learned from a late diagnosis

Pier, Danielle B.; Hallbergson, Anna; Peters, Jurriaan M.

doi:10.1111/j.1651-2227.2010.01860.x

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…As limitation of the present study lies in its retrospective nature, the conclusion reached requires further confirmation in a prospective study based on a larger number of cases. It has been reported that, in GBS patients with severe pain, the contrast enhancement on magnetic resonance imaging is seen in the nerve roots . Among the present 10 cases with pain, Lasègue's sign was positive in two cases; and one of the patients (case 7), in whom the magnetic resonance imaging was evaluated, showed contrast enhancement in the lumbar nerve roots.…”

Section: Discussionmentioning

confidence: 49%

“…It has been reported that, in GBS patients with severe pain, the contrast enhancement on magnetic resonance imaging is seen in the nerve roots. 6,15,19 Among the present 10 cases with pain, Las egue's sign was positive in two cases; and one of the patients (case 7), in whom the magnetic resonance imaging was evaluated, showed contrast enhancement in the lumbar nerve roots. In the remaining cases, however, spinal magnetic resonance imaging was not obtained.…”

Section: Discussionmentioning

confidence: 63%

“…In the study of 27 patients with GBS by Taniguchi et al ., 10 out of 18 GBS patients with pain developed pain before or at the onset of motor weakness, and most of them were aged 20–40 years . In fact, in children with GBS, pain can be one of the most common presenting symptoms . It might be caused by the age‐related sensitivity to pain.…”

Section: Discussionmentioning

confidence: 99%

“…5 In fact, in children with GBS, pain can be one of the most common presenting symptoms. [13][14][15] It might be caused by the age-related sensitivity to pain. In a study of healthy subjects, Lautenbacher showed that the younger subjects had lower pain threshold than the elderly subjects.…”

Section: Discussionmentioning

confidence: 99%

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Pain in the acute phase of Guillain–Barré syndrome

Kinboshi

Inoue

Kojima

et al. 2014

Neurology & Clinical Neurosc

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Background and Aim: Pain has not been recognized as a main feature of GuillainBarr e syndrome (GBS) in its acute phase. The pathophysiology of pain and its effect on the prognostic outcome of GBS have not been fully evaluated. The aim of the present study was to report the clinical features and prognosis of GBS patients presenting with pain in the acute phase.Methods: This was a retrospective study of 34 consecutive patients with GBS. We compared clinical profiles and laboratory findings between the GBS patients with pain and those without pain. Results: A total of 29% of GBS patients had pain in the acute phase. Among others, low back pain was most common. GBS patients with pain were significantly younger than those without pain. In GBS patients with pain, the time of admission, the time for starting treatment and the time of discharge from the hospital were significantly delayed as compared with those without pain. However, there was no difference in the preceding infections, laboratory findings, or disability at the time of nadir and discharge. Conclusion: Pain is relatively common in the acute phase of GBS. Young GBS patients are especially susceptible to pain. Pain in the acute phase of GBS delays the time for reaching the correct diagnosis, and prolongs the duration of hospital stay and recovery, although it does not influence the functional prognosis.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pain in the acute phase of Guillain–Barré syndrome

Kinboshi

Inoue

Kojima

et al. 2014

Neurology & Clinical Neurosc

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“…There may be several reasons for these discrepancies. GBS is more difficult to diagnose in younger age groups, especially in pediatric patients, and varying rates in some study areas may reflect diagnostic uncertainty and either over-or underdiagnosis of GBS in younger patients [35,36] . The lower incidence of GBS in older age groups may reflect a survivor bias, in which individuals surviving into their 80s and 90s are less likely to develop GBS, although there is no substantiated biological basis for this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis

Sejvar

Baughman²,

Wise³

et al. 2011

Neuroepidemiology

783

601

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Population incidence of Guillain-Barré syndrome (GBS) is required to assess changes in GBS epidemiology, but published estimates of GBS incidence vary greatly depending on case ascertainment, definitions, and sample size. We performed a meta-analysis of articles on GBS incidence by searching Medline (1966–2009), Embase (1988–2009), Cinahl (1981–2009) and CABI (1973–2009) as well as article bibliographies. We included studies from North America and Europe with at least 20 cases, and used population-based data, subject matter experts to confirm GBS diagnosis, and an accepted GBS case definition. With these data, we fitted a random-effects negative binomial regression model to estimate age-specific GBS incidence. Of 1,683 nonduplicate citations, 16 met the inclusion criteria, which produced 1,643 cases and 152.7 million person-years of follow-up. GBS incidence increased by 20% for every 10-year increase in age; the risk of GBS was higher for males than females. The regression equation for calculating the average GBS rate per 100,000 person-years as a function of age in years was exp[–12.0771 + 0.01813(age in years)] × 100,000. Our findings provide a robust estimate of background GBS incidence in Western countries. Our regression model may be used in comparable populations to estimate the background age-specific rate of GBS incidence for future studies.

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