“…3 : The tumor follicular T-helper cells activate B cells, which turn into plasma cells and produce large amounts of antibodies. Furthermore, in several case reports AIDP has been linked to AITL [ 8 , 9 ]. Fig.…”
“…3 : The tumor follicular T-helper cells activate B cells, which turn into plasma cells and produce large amounts of antibodies. Furthermore, in several case reports AIDP has been linked to AITL [ 8 , 9 ]. Fig.…”
“…AITL is a rare systemic lymphoproliferative disorder but represents one of the most frequent subtypes 18% of peripheral T cell lymphomas [2]. Clinical aspect associates generalized lymphadenopathy, fever, weight loss, hepatosplenomegaly, pleural effusion, ascites and nonspecific cutaneous involvement such as morbilliform eruptions, urticarial, purpura and pruritus.…”
Angioimmunoblastic T-cell lymphoma (AITL) is an uncommon systemic lymphoproliferative disorder that comprises 18% of all peripheral T cell lymphomas. We report a case of AITL discovered during a paraclinical assessment of chronic pruritus.
Guillain-Barré syndrome (GBS) is a rare condition caused by autoimmune damage of peripheral nerves. We describe a case where a man in his 80s presented with subacute, progressive fatigue and weakness. He had received an outpatient work-up for possible haematological malignancy, but eventually presented to the emergency department for worsening weakness. A physical exam and cerebrospinal fluid analysis suggested a diagnosis of GBS. Subsequently, a pathological diagnosis of angioimmunoblastic T-cell lymphoma was made. The patient underwent intravenous immunoglobulin treatment for GBS and was started on cyclophosphamide, doxorubicin, vincristine and prednisone therapy. Prior research has suggested that incident malignancy may be associated with GBS, which may be caused by a paraneoplastic-type phenomenon, malignancy-associated immune dysregulation or an autoimmune reaction triggered by a common exposure. Clinicians should be aware of the possible association between these two conditions and should remain open minded to the possibility of non-infectious triggers for GBS.
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