Guillain-Barre' Syndrome Following Scrub Typhus

Pandey, Shishir; Chaudhari, Dinesh; Renjen, Pushpendra Nath; Ahmad, Kamal

doi:10.4103/aian.aian_471_20

Cited by 4 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,20,21 Among the preceding infections, GBS occurring after scrub typhus has not been reported yet, and the association with the disease and the characteristics of the disease itself are poorly understood. [11][12][13][14] Although peripheral neuropathy caused by scrub typhus is exceedingly rare, differentiating whether these presented patients can be attributed to scrub typhus-related polyradiculoneuro- considering that the typical incubation period of scrub typhus is 7-10 days, GBS was considered a plausible possibility. 22 Scrub typhus has been known since a serological test was performed in Korea in 1986.…”

Section: Discussionmentioning

confidence: 99%

“…As GBS can occur even after COVID‐19 infection and vaccination, the relationship between COVID‐19 infection and GBS is an important topic 8,20,21 . Among the preceding infections, GBS occurring after scrub typhus has not been reported yet, and the association with the disease and the characteristics of the disease itself are poorly understood 11–14 . Although peripheral neuropathy caused by scrub typhus is exceedingly rare, differentiating whether these presented patients can be attributed to scrub typhus‐related polyradiculoneuropathy or diagnosed as GBS remains challenging.…”

Section: Discussionmentioning

confidence: 99%

“…Scrub typhus mainly occurs in the Tsutsugamushi Triangle, covering Asia, India, Australia, and the islands of the Indian and Pacific Oceans 9,10 . Although scrub typhus infection is associated with GBS pathogenesis, its mechanism remains unknown 11–14 …”

Section: Introductionmentioning

confidence: 99%

“…9,10 Although scrub typhus infection is associated with GBS pathogenesis, its mechanism remains unknown. [11][12][13][14] Scrub typhus can cause serious complications and neurological problems, such as cerebral infarction, peripheral neuropathy, Bell's palsy, rhabdomyolysis, and myopathy. 10,15,16 In addition to the symptoms caused by scrub typhus, severe motor or sensory neurological symptoms, autonomic nervous system symptoms, and respiratory failure requiring ventilator application may occur because of GBS development after scrub typhus.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Clinical and laboratory findings in scrub typhus associated Guillain‐Barré syndrome in South Korea

Yoon,

Kim,

Kim

et al. 2024

J Peripheral Nervous Sys

View full text Add to dashboard Cite

Background and AimsScrub typhus is an endemic disease in the fall season that occurs in a limited number of places known as the Tsutsugamushi Triangle. Peripheral neuropathy is a common complication of scrub typhus. Herein, we encountered several patients with ascending paralysis after scrub typhus infection, who were diagnosed with Guillain‐Barré syndrome (GBS). We aimed to investigate the clinical and laboratory characteristics of patients who developed GBS after scrub typhus.MethodsPatients were retrospectively recruited from six nationwide tertiary centers in South Korea from January 2017 to December 2021. Patients who had been clinically diagnosed with GBS and confirmed to have scrub typhus via laboratory examination and/or the presence of an eschar before the onset of acute limb paralysis were included. The GBS‐associated clinical and electrophysiological characteristics, outcomes, and scrub typhus‐associated features were collected.ResultsOf the seven enrolled patients, six were female and one was male. The median time from scrub typhus infection to the onset of limb weakness was 6 (range: 2–14) days. All patients had eschar on their bodies. Four patients (57.1%) were admitted to the intensive care unit and received artificial ventilation for respiratory distress. At 6 months, the median GBS disability score was 2 (range, 1–4) points.InterpretationPatients with scrub typhus‐associated GBS have a severe clinical presentation and require intensive treatment with additional immunotherapies. Therefore, GBS should be included in the differential diagnosis when peripheral neuropathies develop during scrub typhus treatment. Notably, scrub typhus is associated to GBS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Clinical and laboratory findings in scrub typhus associated Guillain‐Barré syndrome in South Korea

Yoon,

Kim,

Kim

et al. 2024

J Peripheral Nervous Sys

View full text Add to dashboard Cite

show abstract

“…Scrub Typhus caused by a bacteria called Orientia tsutsugamushi (O. tsutsugamushi). 1 It is a systemic illness that causes generalized vasculitis in the affected individuals. Disease is acquired by bite of infected chiggers (larval mites), 2 especially in rural areas.…”

Section: Sirmentioning

confidence: 99%

Guillain – Barre syndrome with no known etiology: Rule out scrub typhus

Singla¹,

Daunaria²,

Jamir³

2023

IJCA

View full text Add to dashboard Cite

show abstract

Guillain–Barre syndrome following scrub typhus: a case report and literature review

Hu,

lin,

Liu

et al. 2024

BMC Neurol

View full text Add to dashboard Cite

Background Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi. Guillain–Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy with a frequent history of prodromal infections, but GBS associated with scrub typhus is very rare. Case presentation We report a 51-year-old male patient who developed dysarthria and peripheral facial paralysis following the cure of scfrub typhus. CSF examination and electrophysiological findings suggested a diagnosis of GBS. After treatment with intravenous immunoglobulin, the patient’s neurological condition improved rapidly. Conclusions Scrub typhus infection is likely to be a potential predisposing factor in GBS, while scrub typhus-associated GBS has a favorable prognosis.

show abstract

Guillain-Barre' Syndrome Following Scrub Typhus

Cited by 4 publications

References 7 publications

Clinical and laboratory findings in scrub typhus associated Guillain‐Barré syndrome in South Korea

Clinical and laboratory findings in scrub typhus associated Guillain‐Barré syndrome in South Korea

Guillain – Barre syndrome with no known etiology: Rule out scrub typhus

Guillain–Barre syndrome following scrub typhus: a case report and literature review

Contact Info

Product

Resources

About