Guillain-Barré syndrome following COVID-19: a newly emerging post-infectious complication

Webb, Silas; Wallace, Victoria C.J.; Martín-López, David; Yogarajah, Mahinda

doi:10.1136/bcr-2020-236182

Cited by 85 publications

(80 citation statements)

References 10 publications

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“…In all ( n = 72) but four patients [ 10 , 37 , 40 , 56 ], GBS manifestations developed after those of COVID-19 [median (IQR): 14 (7–20), min 2–max 33 days]. Differently, COVID-19 symptoms began concurrent in one case [ 37 ], 1 day [ 40 ] and 8 days [ 55 ] after GBS onset in two other cases and never developed in another one [ 10 ] (Table 1 ). Common clinical manifestations at onset included sensory symptoms (72.2%, 52/72) alone or in combination with paraparesis or tetraparesis (65.2%, 47/72, respectively).…”

Section: Resultsmentioning

confidence: 99%

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

et al. 2020

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Since coronavirus disease-2019 (COVID-19) outbreak in January 2020, several pieces of evidence suggested an association between the spectrum of Guillain-Barré syndrome (GBS) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most findings were reported in the form of case reports or case series, whereas a comprehensive overview is still lacking. We conducted a systematic review and searched for all published cases until July 20th 2020. We included 73 patients reported in 52 publications. A broad age range was affected (mean 55, min 11-max 94 years) with male predominance (68.5%). Most patients showed respiratory and/or systemic symptoms, and developed GBS manifestations after COVID-19. However, asymptomatic cases for COVID-19 were also described. The distributions of clinical variants and electrophysiological subtypes resemble those of classic GBS, with a higher prevalence of the classic sensorimotor form and the acute inflammatory demyelinating polyneuropathy, although rare variants like Miller Fisher syndrome were also reported. Cerebrospinal fluid (CSF) albuminocytological dissociation was present in around 71% cases, and CSF SARS-CoV-2 RNA was absent in all tested cases. More than 70% of patients showed a good prognosis, mostly after treatment with intravenous immunoglobulin. Patients with less favorable outcome were associated with a significantly older age in accordance with previous findings regarding both classic GBS and COVID-19. COVID-19-associated GBS seems to share most features of classic post-infectious GBS and possibly the same immune-mediated pathogenetic mechanisms. Nevertheless, more extensive epidemiological studies are needed to clarify these issues.

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Section: Resultsmentioning

confidence: 99%

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

et al. 2020

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“… 4 Auditory Impairment 2 Articles [ 62 ] [ 57 ] 5 NR in all articles. 5 Glossopharyngeal neuralgia 1 Article [ 57 ] 9 NR GBS and other Neuropathies 6 GBS and GBS variants 36 Articles [ 60 ], [ 63 ], [ 101 ], [ 191 ], [ 215 ], [ 218 ], [ 219 ], [ 220 ], [ 221 ], [ 222 ], [ 223 ], [ 224 ], [ 225 ], [ 226 ], [ 227 ], [ 228 ], [ 229 ], [ 230 ] [ 231 ] [ 232 ] [ 233 ] [ 234 ] [ 235 ] [ 236 ], [ 237 ], [ 238 ], [ 239 ], [ 240 ] [ 241 ] [ 242 ], [ 243 ], [ 244 ] [ 245 ] [ 246 ], [ 247 ], [ 248 ] 52 NR in all articles. Su XW et al [ 226 ], reoorted a patient GBS with dysautonomia.…”

Section: Resultsmentioning

confidence: 99%

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

183

182

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Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. Methods: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. Results: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. Conclusion: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely.

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“… España, 2020 33 RC 1 Masculino 43 años -Diarrea, infección respiratoria alta -Cuadriparesia, cuadriplejia -Arreflexia global -Paresia facial bilateral -Disfagia (+) PCR -Ig -Hidroxicloroquina -Antirretrovirales -Antibióticos -Corticoides Favorable Virani A. EE.UU., 2020 34 RC 1 Masculino 54 años -Fiebre, tos, diarrea -Debilidad y arreflexia extremidades inferiores y superiores -Dificultad respiratoria (+) PCR -Ig -Hidroxicloroquina Favorable Webb S. Inglaterra, 2020 35 RC 1 Masculino 57 años -Tos, dolor de cabeza, mialgia -Debilidad muscular extremidades inferiores, paresia -Arreflexia global (+) PCR, hisopo nasofaríngeo (-) LCR -Ig Favorable Zhao H. China, 2020 36 RC 1 Femenino 61 años -Fiebre, tos, dolor pecho, diarrea -Debilidad muscular EEII y arreflexia (+) PCR, hisopo nasofaríngeo -Ig -Antirretrovirales Favorable N: Número de pacientes, NR: No reportado, RC: Reporte de caso, SC: Serie de casos, EEII: Extremidad inferior, LCR: Líquido cefalorraquídeo, PCR: Reacción en cadena de la polimerasa, Ig: Inmunoglobulinas, ┼ Fallecido. …”

Section: Resultsunclassified

Relación entre COVID-19 y síndrome de Guillain-Barré en adultos. Revisión sistemática

Gittermann¹,

Feris²,

Giacoman³

2020

Neurología

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Introducción Se han reportado distintos casos de pacientes con cuadro de síndrome de Guillain-Barré asociado a COVID-19, pero falta mucha información aún sobre esta asociación y sus implicancias, el objetivo de esta revisión es analizar la evidencia disponible en esta temática en la población adulta. Material y Métodos Se realizó una revisión sistemática de estudios publicados en buscadores científicos: PubMed, Cochrane, Science Direct, Medline, OMS COVID-19. Resultados Se identificaron 45 estudios, los cuales se analizaron y completaron utilizando la plataforma Covidence, incluyendo para el análisis final 24 artículos y sumando un total de 30 pacientes. Conclusiones Se demuestra una asociación fuerte entre ambas patologías, además, los estudios analizados recalcan diferencias en la presentación de la enfermedad con mayor gravedad en los cuadros de síndrome de Guillain-Barré asociados a COVID-19.

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Guillain-Barré syndrome following COVID-19: a newly emerging post-infectious complication

Cited by 85 publications

References 10 publications

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Relación entre COVID-19 y síndrome de Guillain-Barré en adultos. Revisión sistemática

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