Guillain-Barré syndrome following chickenpox: a case series

Tatarelli, Paola; Garnero, Martina; Bono, Valerio Del; Camera, M. La; Schenone, Angelo; Grandis, Marina; Benedetti, Luana; Viscoli, Claudio

doi:10.3109/00207454.2015.1033621

Cited by 12 publications

(13 citation statements)

References 2 publications

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“…Malignant varicella in adults Immunocompetent is an emergency involving the functional prognosis and vital with a risk of mortality, mainly related to pneumonia Varicella in 30%, greater after 50 years and complications Neurological disorders [4]. The treatment is based, in addition to the measures of resuscitation and local care on Aciclovir at 10 mg/kg/ 08h for one Minimum of seven days [1,2,4]. The delay in management anticipates mortality and functional sequelae [3].…”

Section: Discussionmentioning

confidence: 99%

“…Varicella zoster virus (VZV) is a rare cause of GBS, mainly in the case of latent infection reactivation [1,2]; we report here a case of severe GBS following primary VZV infection in an immunocompetent adult.…”

Section: Introductionmentioning

confidence: 97%

“…Guillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy, usually triggered by an infectious episode, mostly of viral origin [1]. Varicella zoster virus (VZV) is a rare cause of GBS, mainly in the case of latent infection reactivation [1,2]; we report here a case of severe GBS following primary VZV infection in an immunocompetent adult.…”

Section: Introductionmentioning

confidence: 98%

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Guillain-Barré Syndrome Following a Malignant Varicella in Immunocompetent Adult

Elmahi¹,

Baybay²,

Issoual³

et al. 2017

IJCDR

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Guillain-Barré Syndrome Following a Malignant Varicella in Immunocompetent Adult

Elmahi¹,

Baybay²,

Issoual³

et al. 2017

IJCDR

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“…In most cases, GBS follows an infection due to Campylobacter jejuni or cytomegalovirus and, more rarely, Mycoplasma pneumoniae, influenza virus, Zika virus, and Epstein-Barr virus (33)(34)(35)(36)(37). The association of GBS with other pathogens, such as measles virus, varicellazoster virus and Haemophilus influenzae, is debated (38)(39)(40). Four main subtypes of GBS, which are differentiated by nerve electrophysiological findings, have been identified: acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher syndrome (41).…”

Section: Guillain-barre' Syndrome (Gbs)mentioning

confidence: 99%

Do Vaccines Have a Role as a Cause of Autoimmune Neurological Syndromes?

Principi

Esposito

2020

Front. Public Health

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Vaccines are the most important preventive measure against infectious diseases presently available. Although they have led to the eradication or the elimination of some infectious diseases, concerns about safety are among the main reasons for vaccine hesitancy. In some cases, the biological plausibility of a given damage in association with the temporal association between vaccine administration and disease development makes it difficult to define causality and can justify hesitancy. Only well-conducted epidemiological studies with adequate evaluation of results can clarify whether a true association between vaccines and adverse event development truly exists. Autoimmune neurological syndromes that follow vaccine use are among these. In this narrative review, the potential association between vaccines and the development of these syndromes are discussed. Literature analysis showed that most of the associations between vaccines and nervous system autoimmune syndromes that have been reported as severe adverse events following immunization are no longer evidenced when well-conducted epidemiological studies are carried out. Although the rarity of autoimmune diseases makes it difficult to strictly exclude that, albeit exceptionally, some vaccines may induce an autoimmune neurological disease, no definitive demonstration of a potential role of vaccines in causing autoimmune neurological syndromes is presently available. Consequently, the fear of neurological autoimmune disease cannot limit the use of the most important preventive measure presently available against infectious diseases.

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“…Of the 24 reported patients [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] who developed GBS after chicken pox (Table 1), 17 (71%) were male (age range, 2 to 53 years old). Duration between skin rash and developing weakness ranged from 4 to 21 days.…”

Section: Gbs Following Chicken Pox or Varicellamentioning

confidence: 99%

Guillain-Barré syndrome following varicella-zoster virus infection

Islam

GeurtsvanKessel

et al. 2018

Eur J Clin Microbiol Infect Dis

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We describe the frequency, clinical features, and electrophysiological and immunological phenotypes of Guillain-Barré Syndrome (GBS) patients treated at a single institution in Bangladesh who had preceding chicken pox (primary Varicella-zoster virus [VZV] infection) within 4 weeks of GBS onset. A literature review of GBS cases preceding VZV infection is also provided. Diagnosis of GBS was based on the National Institute of Neurological Disorders and Stroke criteria for GBS. Serum anti-VZV IgM and IgG antibodies were quantified by indirect chemiluminescence immunoassay (CLIA); anti-Campylobacter jejuni IgG, IgM, and IgA antibodies and anti-ganglioside GM1 IgM and IgG antibodies, by enzyme-linked immunosorbent assays. Neurophysiologic subtypes were categorized following the Hadden criteria. Of 536 patients with GBS, 7 (1.3%) had chicken pox within 4 weeks before GBS onset. Four of the seven cases were male (age range, 23 to 40 years old). All seven patients were bed-bound, six had sensory symptoms, and three required mechanical ventilation for respiratory failure. All seven patients had CSF albuminocytologic dissociation and evidence of demyelination in nerve conduction studies. Anti-VZV IgM antibodies were present and anti-GM1 and anti-Campylobacter jejuni lipo-oligosaccharides (LOS) were negative in all cases. All patients had excellent outcome at 1 year (able to run). A systematic literature review of GBS cases related to VZV revealed 39 previously reported patients with comparable clinical presentations and outcomes, of which 36 had neurophysiologic evidence of demyelination. VZV infection is associated with the demyelinating subtype of GBS, clearly distinct from the axonal form of GBS that predominate in countries like Bangladesh.

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Guillain-Barré syndrome following chickenpox: a case series

Cited by 12 publications

References 2 publications

Guillain-Barré Syndrome Following a Malignant Varicella in Immunocompetent Adult

Guillain-Barré Syndrome Following a Malignant Varicella in Immunocompetent Adult

Do Vaccines Have a Role as a Cause of Autoimmune Neurological Syndromes?

Guillain-Barré syndrome following varicella-zoster virus infection

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