Guillain-Barré Syndrome Associated With Zika Virus Infection in Martinique in 2016: A Prospective Study

Rozé, B.; Najioullah, Fatiha; Fergé, Jean-Louis; Dorléans, Fréderique; Apétsè, Kossivi; Barnay, José‐Luis; Daudens-Vaysse, Elise; Brouste, Yannick; Césaire, Raymond; Fagour, Laurence; Valentino, Ruddy; Ledrans, Martine; Mehdaoui, Hossein; Abel, Sylvie; Leparc-Goffart, Isabelle; Signaté, Aïssatou; Cabie, André

doi:10.1093/cid/cix588

Cited by 51 publications

(41 citation statements)

References 33 publications

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“…These results support previous findings indicating an association between arboviruses and neuropathies in Brazil during the Zika virus epidemic . The rates of rash, facial paralysis, and paraparesis in patients with GBS in Metropolitan Area II are similar to those previously reported for GBS cases in Latin America and the Caribbean . Our classification of the cause of inflammatory polyneuropathies was based on signs and symptoms reported by the patient and investigated by physicians.…”

Section: Discussionsupporting

confidence: 90%

“…Treatment involves plasma exchange or intravenous immunoglobulin. Although the most frequent causes of GBS are Campylobacter jejuni , Cytomegalovirus , and influenza A, the disorder has also been associated with dengue virus and Zika virus . During the Zika virus epidemic in Rio de Janeiro, Brazil, during the period 2015–2016, it was shown that neuropathies increased .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neurological complications associated with emerging viruses in Brazil

Angelo

Fuller

Leandro

et al. 2020

Intl J Gynecology & Obste

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Neurological complications associated with emerging viruses in Brazil

Angelo

Fuller

Leandro

et al. 2020

Intl J Gynecology & Obste

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“…We reviewed 135 full-text articles, of which 31 were eligible for inclusion ( Fig 1). Of the 31 studies, 28 reported countryspecific GBS rates from 13 LAC countries (Tables 1 & 2), 3 regional rates, [18,35,36] 15 background rates [18,[35][36][37][38][39][40][41][42][43][44][45][46][47][48], 11 rates during an arboviral outbreak [49][50][51][52][53][54][55][56][57][58][59], and 5 compared rates before and during an outbreak [27,[60][61][62][63]. Many studies presented data from Brazil (29%) and Colombia (16%), and the majority (68%) were published in 2015 or later.…”

Section: Resultsmentioning

confidence: 99%

Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean Before and During the 2015-2016 Zika Virus Epidemic: A Systematic Review and Meta-Analysis

et al. 2019

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BackgroundA severe neurological disorder, Guillain-Barré syndrome (GBS) is the leading cause of acute flaccid paralysis. Enhanced surveillance of GBS in Latin America and the Caribbean (LAC) following the 2015-2016 Zika virus (ZIKV) epidemic presents an opportunity to estimate, for the first time, the regional incidence of GBS. Methods and findingsFor this systematic review and meta-analysis, we searched nine scientific databases and grey literature from January 1, 1980 to October 1, 2018. Sources with primary data on incident GBS cases in LAC within a well-defined population and timeframe, published in English, Spanish, Portuguese, or French, were included. We calculated the annual GBS incidence rates (IRs) and 95% confidence intervals (CIs) for each source based on published data. Following an assessment of heterogeneity, we used random-effects meta-analysis to calculate the pooled annual IR of GBS. The study is registered with PROSPERO, number CRD42018086659. Of the 6568 initial citation hits, 31 were eligible for inclusion. Background annual GBS IRs in Latin America ranged from 0.40 in Brazil to 2.12/100,000 in Chile. The pooled annual IR in the Caribbean was 1.64 (95% CI 1.29-2.12, I 2 <0.01, p = 0.44). During the ZIKV epidemic, GBS IRs ranged from 0.62 in Mexico to 9.35/100,000 in Martinique. GBS increased 2.6 (95% CI 2.3-2.9) times during ZIKV and 1.9 (95% CI 1.1-3.4) times during chikungunya outbreaks over background rates. ConclusionsBackground IRs of GBS appear to peak during arboviral disease outbreaks. The current review contributes to an understanding of the epidemiology of GBS in the LAC region, which can inform healthcare system planning and preparedness, particularly during arboviral epidemics. Trial registrationRegistered with PROSPERO: CRD42018086659. Author summaryA severe neurological disorder, Guillain-Barré syndrome (GBS) is the leading cause of acute flaccid paralysis. This is the first systematic review on GBS incidence in Latin America and the Caribbean before and during arboviral disease outbreaks. There is a large subregional and annual fluctuation in the incidence of GBS. Background annual GBS incidence rates (IRs) in Latin America ranged from 0.40 in Brazil to 2.12/100,000 in Chile. The pooled annual IR in the Caribbean was 1.64 (95% CI 1.29-2.12, I 2 <0.01, p = 0.44). During the ZIKV epidemic, GBS IRs ranged from 0.62 in Mexico to 9.35/100,000 in Martinique. GBS increased 2.6 times during ZIKV and 1.9 times during chikungunya outbreaks over background rates. GBS is a costly disease, which can result in long-term disability and high mortality rates in resource constrained healthcare settings. Because GBS can be triggered by arboviral infections, baseline incidence of GBS is critical for detecting neglected tropical disease outbreaks. The current review contributes to an understanding of the epidemiology of GBS in the LAC region, which can inform healthcare system planning and preparedness.Incidence of Guillain-Barré Syndrome in LAC and arboviral disease outbreaks PLOS Neglected Tropic...

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“…GBS comprises an acute inflammatory demyelinating polyneuropathy of global incidence, in which about two-thirds of cases occur after bacterial (e.g. Campylobacter jejuni) (Heikema et al, 2015) or viral infection (Oehler et al, 2015), such as by Dengue- (Simon et al, 2016), West Nile- (Leis and Stokic, 2012), Influenza- (Choi and Yeon, 2016), Cytomegalo- (Steger et al, 2012), Human Immunodeficiency- (Girgin et al, 2014), Epstein-Barr (Phillips, 1973;Kim et al, 2016) and Zika viruses (Rozé et al, 2017).…”

Section: Atypicalmentioning

confidence: 99%

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

et al. 2018

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Chikungunya fever is a mosquito-borne viral illness characterized by a sudden onset of fever associated with joint pains. It was first described in the 1950s during a Chikungunya virus (CHIKV) outbreak in southern Tanzania and has since (re-) emerged and spread to several other geographical areas, reaching large populations and causing massive epidemics. In recent years, CHIKV has gained considerable attention due to its quick spread to the Caribbean and then in the Americas, with many cases reported between 2014 and 2017. CHIKV has further garnered attention due to the clinical diagnostic difficulties when Zika (ZIKV) and dengue (DENV) viruses are simultaneously present. In this review, topical CHIKV-related issues, such as epidemiology and transmission, are examined. The different manifestations of infection (acute, chronic and atypical) are described and a particular focus is placed upon the diagnostic handling in the case of ZIKV and DENV co-circulating. Natural and synthetic compounds under evaluation for treatment of chikungunya disease, including drugs already licensed for other purposes, are also discussed. Finally, previous and current vaccine strategies, as well as the control of the CHIKV transmission through an integrated vector management, are reviewed in some detail.

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Guillain-Barré Syndrome Associated With Zika Virus Infection in Martinique in 2016: A Prospective Study

Abstract: ZIKV infection is usually benign, when symptomatic, but in countries at risk of ZIKV epidemics, adequate intensive care bed capacity is required for management of severe GBS cases. Arbovirus RNA detection by RT-PCR should be part of the management of GBS cases.

Cited by 51 publications

References 33 publications

Neurological complications associated with emerging viruses in Brazil

Neurological complications associated with emerging viruses in Brazil

Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean Before and During the 2015-2016 Zika Virus Epidemic: A Systematic Review and Meta-Analysis

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

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